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SU5416 induces premature senescence in endothelial progenitor cells from patients with age-related macular degeneration.

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SU5416 induces premature senescence in endothelial progenitor cells from patients with age-related macular degeneration. / Berna-Thill, Michelle; Berna, Marc; Kunst, Frank; Wege, Henning; Strunnikova, Natalya V; Gordiyenko, Natalya; Grierson, Rebecca; Richard, Gisbert; Csaky, Karl G.

In: MOL VIS, Vol. 17, 2011, p. 85-98.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Berna-Thill, M, Berna, M, Kunst, F, Wege, H, Strunnikova, NV, Gordiyenko, N, Grierson, R, Richard, G & Csaky, KG 2011, 'SU5416 induces premature senescence in endothelial progenitor cells from patients with age-related macular degeneration.', MOL VIS, vol. 17, pp. 85-98. <http://www.ncbi.nlm.nih.gov/pubmed/21245959?dopt=Citation>

APA

Berna-Thill, M., Berna, M., Kunst, F., Wege, H., Strunnikova, N. V., Gordiyenko, N., Grierson, R., Richard, G., & Csaky, K. G. (2011). SU5416 induces premature senescence in endothelial progenitor cells from patients with age-related macular degeneration. MOL VIS, 17, 85-98. http://www.ncbi.nlm.nih.gov/pubmed/21245959?dopt=Citation

Vancouver

Berna-Thill M, Berna M, Kunst F, Wege H, Strunnikova NV, Gordiyenko N et al. SU5416 induces premature senescence in endothelial progenitor cells from patients with age-related macular degeneration. MOL VIS. 2011;17:85-98.

Bibtex

@article{88af66191ae340d7b0bdb22d7fdcd1ea,
title = "SU5416 induces premature senescence in endothelial progenitor cells from patients with age-related macular degeneration.",
abstract = "We recently demonstrated increased frequency and growth potential of late outgrowth endothelial progenitor cells (OECs) in patients with neovascular age-related macular degeneration (nvAMD). This study investigated the effects of short- and long-term in vitro inhibition of vascular endothelial growth factor (VEGF) Receptor-2 (VEGFR-2) signaling by SU5416 and other inhibitors of the VEGF signaling pathway in OECs.",
keywords = "Humans, Treatment Outcome, Apoptosis, Signal Transduction, Cell Aging/*drug effects, Endothelial Cells/cytology/*drug effects, Indoles/*pharmacology, Macular Degeneration/*drug therapy/metabolism, Phosphatidylinositol 3-Kinases/antagonists & inhibitors, Protein Kinase C/metabolism, Protein Kinase Inhibitors/pharmacology, Pyrroles/*pharmacology, Receptors, CXCR4/biosynthesis, Stem Cells/cytology/*drug effects, Umbilical Veins/cytology, Vascular Endothelial Growth Factor Receptor-2/biosynthesis/metabolism, Humans, Treatment Outcome, Apoptosis, Signal Transduction, Cell Aging/*drug effects, Endothelial Cells/cytology/*drug effects, Indoles/*pharmacology, Macular Degeneration/*drug therapy/metabolism, Phosphatidylinositol 3-Kinases/antagonists & inhibitors, Protein Kinase C/metabolism, Protein Kinase Inhibitors/pharmacology, Pyrroles/*pharmacology, Receptors, CXCR4/biosynthesis, Stem Cells/cytology/*drug effects, Umbilical Veins/cytology, Vascular Endothelial Growth Factor Receptor-2/biosynthesis/metabolism",
author = "Michelle Berna-Thill and Marc Berna and Frank Kunst and Henning Wege and Strunnikova, {Natalya V} and Natalya Gordiyenko and Rebecca Grierson and Gisbert Richard and Csaky, {Karl G}",
year = "2011",
language = "English",
volume = "17",
pages = "85--98",
journal = "MOL VIS",
issn = "1090-0535",
publisher = "Molecular Vision",

}

RIS

TY - JOUR

T1 - SU5416 induces premature senescence in endothelial progenitor cells from patients with age-related macular degeneration.

AU - Berna-Thill, Michelle

AU - Berna, Marc

AU - Kunst, Frank

AU - Wege, Henning

AU - Strunnikova, Natalya V

AU - Gordiyenko, Natalya

AU - Grierson, Rebecca

AU - Richard, Gisbert

AU - Csaky, Karl G

PY - 2011

Y1 - 2011

N2 - We recently demonstrated increased frequency and growth potential of late outgrowth endothelial progenitor cells (OECs) in patients with neovascular age-related macular degeneration (nvAMD). This study investigated the effects of short- and long-term in vitro inhibition of vascular endothelial growth factor (VEGF) Receptor-2 (VEGFR-2) signaling by SU5416 and other inhibitors of the VEGF signaling pathway in OECs.

AB - We recently demonstrated increased frequency and growth potential of late outgrowth endothelial progenitor cells (OECs) in patients with neovascular age-related macular degeneration (nvAMD). This study investigated the effects of short- and long-term in vitro inhibition of vascular endothelial growth factor (VEGF) Receptor-2 (VEGFR-2) signaling by SU5416 and other inhibitors of the VEGF signaling pathway in OECs.

KW - Humans

KW - Treatment Outcome

KW - Apoptosis

KW - Signal Transduction

KW - Cell Aging/drug effects

KW - Endothelial Cells/cytology/drug effects

KW - Indoles/pharmacology

KW - Macular Degeneration/drug therapy/metabolism

KW - Phosphatidylinositol 3-Kinases/antagonists & inhibitors

KW - Protein Kinase C/metabolism

KW - Protein Kinase Inhibitors/pharmacology

KW - Pyrroles/pharmacology

KW - Receptors, CXCR4/biosynthesis

KW - Stem Cells/cytology/drug effects

KW - Umbilical Veins/cytology

KW - Vascular Endothelial Growth Factor Receptor-2/biosynthesis/metabolism

KW - Humans

KW - Treatment Outcome

KW - Apoptosis

KW - Signal Transduction

KW - Cell Aging/drug effects

KW - Endothelial Cells/cytology/drug effects

KW - Indoles/pharmacology

KW - Macular Degeneration/drug therapy/metabolism

KW - Phosphatidylinositol 3-Kinases/antagonists & inhibitors

KW - Protein Kinase C/metabolism

KW - Protein Kinase Inhibitors/pharmacology

KW - Pyrroles/pharmacology

KW - Receptors, CXCR4/biosynthesis

KW - Stem Cells/cytology/drug effects

KW - Umbilical Veins/cytology

KW - Vascular Endothelial Growth Factor Receptor-2/biosynthesis/metabolism

M3 - SCORING: Journal article

VL - 17

SP - 85

EP - 98

JO - MOL VIS

JF - MOL VIS

SN - 1090-0535

ER -