Structure-function-behavior relationship in estrogen-induced synaptic plasticity

R Vierk; J Bayer; S Freitag; M Muhia; K Kutsche; T Wolbers; M Kneussel; Tobias Sommer-Blöchl; G M Rune

doi:10.1016/j.yhbeh.2015.05.008

Structure-function-behavior relationship in estrogen-induced synaptic plasticity

Standard

Structure-function-behavior relationship in estrogen-induced synaptic plasticity. / Vierk, R; Bayer, J; Freitag, S; Muhia, M; Kutsche, K; Wolbers, T; Kneussel, M ; Sommer-Blöchl, Tobias; Rune, G M.

In: HORM BEHAV, Vol. 74, 08.2015, p. 139-48.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Vierk, R, Bayer, J, Freitag, S, Muhia, M, Kutsche, K, Wolbers, T, Kneussel, M , Sommer-Blöchl, T & Rune, GM 2015, 'Structure-function-behavior relationship in estrogen-induced synaptic plasticity', HORM BEHAV, vol. 74, pp. 139-48. https://doi.org/10.1016/j.yhbeh.2015.05.008

APA

Vierk, R., Bayer, J., Freitag, S., Muhia, M., Kutsche, K., Wolbers, T., Kneussel, M., Sommer-Blöchl, T., & Rune, G. M. (2015). Structure-function-behavior relationship in estrogen-induced synaptic plasticity. HORM BEHAV, 74, 139-48. https://doi.org/10.1016/j.yhbeh.2015.05.008

Vancouver

Vierk R, Bayer J, Freitag S, Muhia M, Kutsche K, Wolbers T et al. Structure-function-behavior relationship in estrogen-induced synaptic plasticity. HORM BEHAV. 2015 Aug;74:139-48. https://doi.org/10.1016/j.yhbeh.2015.05.008

Bibtex

@article{fc0ea1578fd84203bfe04070f3b54897,

title = "Structure-function-behavior relationship in estrogen-induced synaptic plasticity",

abstract = "This article is part of a Special Issue {"}Estradiol and Cognition{"}. In estrogen-induced synaptic plasticity, a correlation of structure, function and behavior in the hippocampus has been widely established. 17{\ss}-estradiol has been shown to increase dendritic spine density on hippocampal neurons and is accompanied by enhanced long-term potentiation and improved performance of animals in hippocampus-dependent memory tests. After inhibition of aromatase, the final enzyme of estradiol synthesis, with letrozole we consistently found a strong and significant impairment of long-term potentiation (LTP) in female mice as early as after six hours of treatment. LTP impairment was followed by loss of hippocampal spine synapses in the hippocampal CA1 area. Interestingly, these effects were not found in male animals. In the Morris water maze test, chronic administration of letrozole did not alter spatial learning and memory in either female or male mice. In humans, analogous effects of estradiol on hippocampal morphology and physiology were observed using neuroimaging techniques. However, similar to our findings in mice, an effect of estradiol on memory performance has not been consistently observed.",

author = "R Vierk and J Bayer and S Freitag and M Muhia and K Kutsche and T Wolbers and M Kneussel and Tobias Sommer-Bl{\"o}chl and Rune, {G M}",

year = "2015",

month = aug,

doi = "10.1016/j.yhbeh.2015.05.008",

language = "English",

volume = "74",

pages = "139--48",

journal = "HORM BEHAV",

issn = "0018-506X",

publisher = "Academic Press Inc.",

}

RIS

TY - JOUR

T1 - Structure-function-behavior relationship in estrogen-induced synaptic plasticity

AU - Vierk, R

AU - Bayer, J

AU - Freitag, S

AU - Muhia, M

AU - Kutsche, K

AU - Wolbers, T

AU - Kneussel, M

AU - Sommer-Blöchl, Tobias

AU - Rune, G M

PY - 2015/8

Y1 - 2015/8

N2 - This article is part of a Special Issue "Estradiol and Cognition". In estrogen-induced synaptic plasticity, a correlation of structure, function and behavior in the hippocampus has been widely established. 17ß-estradiol has been shown to increase dendritic spine density on hippocampal neurons and is accompanied by enhanced long-term potentiation and improved performance of animals in hippocampus-dependent memory tests. After inhibition of aromatase, the final enzyme of estradiol synthesis, with letrozole we consistently found a strong and significant impairment of long-term potentiation (LTP) in female mice as early as after six hours of treatment. LTP impairment was followed by loss of hippocampal spine synapses in the hippocampal CA1 area. Interestingly, these effects were not found in male animals. In the Morris water maze test, chronic administration of letrozole did not alter spatial learning and memory in either female or male mice. In humans, analogous effects of estradiol on hippocampal morphology and physiology were observed using neuroimaging techniques. However, similar to our findings in mice, an effect of estradiol on memory performance has not been consistently observed.

AB - This article is part of a Special Issue "Estradiol and Cognition". In estrogen-induced synaptic plasticity, a correlation of structure, function and behavior in the hippocampus has been widely established. 17ß-estradiol has been shown to increase dendritic spine density on hippocampal neurons and is accompanied by enhanced long-term potentiation and improved performance of animals in hippocampus-dependent memory tests. After inhibition of aromatase, the final enzyme of estradiol synthesis, with letrozole we consistently found a strong and significant impairment of long-term potentiation (LTP) in female mice as early as after six hours of treatment. LTP impairment was followed by loss of hippocampal spine synapses in the hippocampal CA1 area. Interestingly, these effects were not found in male animals. In the Morris water maze test, chronic administration of letrozole did not alter spatial learning and memory in either female or male mice. In humans, analogous effects of estradiol on hippocampal morphology and physiology were observed using neuroimaging techniques. However, similar to our findings in mice, an effect of estradiol on memory performance has not been consistently observed.

U2 - 10.1016/j.yhbeh.2015.05.008

DO - 10.1016/j.yhbeh.2015.05.008

M3 - SCORING: Journal article

C2 - 26012713

VL - 74

SP - 139

EP - 148

JO - HORM BEHAV

JF - HORM BEHAV

SN - 0018-506X

ER -