Structure-function relationships in the processing of regret in the orbitofrontal cortex
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Structure-function relationships in the processing of regret in the orbitofrontal cortex. / Sommer-Blöchl, Tobias; Peters, Jan; Gläscher, Jan; Büchel, Christian.
In: BRAIN STRUCT FUNCT, Vol. 213, No. 6, 01.10.2009, p. 535-51.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Structure-function relationships in the processing of regret in the orbitofrontal cortex
AU - Sommer-Blöchl, Tobias
AU - Peters, Jan
AU - Gläscher, Jan
AU - Büchel, Christian
PY - 2009/10/1
Y1 - 2009/10/1
N2 - The influence of counterfactual thinking and regret on choice behavior has been widely acknowledged in economic science (Bell in Oper Res 30:961-981, 1982; Kahneman and Tversky in Judgment under uncertainty: heuristics and biases. Cambridge University Press, Cambridge, pp 201-210, 1982; Loomes and Sugden in Econ J 92:805-824, 1982). Neuroimaging studies have only recently begun to explore the neural correlates of this psychological factor and orbitofrontal cortex (OFC) activity was observed in several of them depending of the exact characteristics of the employed paradigm. This selective OFC involvement and, moreover, a consistently found dissociation of medial and lateral OFC activity clusters allow inferences to the function of this structure in counterfactual thinking and regret. Vice versa, the differential contribution of OFC subregions to these processes also adds evidence to the current debate on the function of this cortical structure in decision-making that attracted increasing attention in recent years.
AB - The influence of counterfactual thinking and regret on choice behavior has been widely acknowledged in economic science (Bell in Oper Res 30:961-981, 1982; Kahneman and Tversky in Judgment under uncertainty: heuristics and biases. Cambridge University Press, Cambridge, pp 201-210, 1982; Loomes and Sugden in Econ J 92:805-824, 1982). Neuroimaging studies have only recently begun to explore the neural correlates of this psychological factor and orbitofrontal cortex (OFC) activity was observed in several of them depending of the exact characteristics of the employed paradigm. This selective OFC involvement and, moreover, a consistently found dissociation of medial and lateral OFC activity clusters allow inferences to the function of this structure in counterfactual thinking and regret. Vice versa, the differential contribution of OFC subregions to these processes also adds evidence to the current debate on the function of this cortical structure in decision-making that attracted increasing attention in recent years.
KW - Choice Behavior
KW - Decision Making
KW - Emotions
KW - Frontal Lobe
KW - Humans
KW - Image Processing, Computer-Assisted
KW - Magnetic Resonance Imaging
U2 - 10.1007/s00429-009-0222-8
DO - 10.1007/s00429-009-0222-8
M3 - SCORING: Journal article
C2 - 19760243
VL - 213
SP - 535
EP - 551
JO - BRAIN STRUCT FUNCT
JF - BRAIN STRUCT FUNCT
SN - 1863-2653
IS - 6
ER -