Structure and flexibility in cortical representations of odour space
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Structure and flexibility in cortical representations of odour space. / Pashkovski, Stan L; Iurilli, Giuliano; Brann, David; Chicharro, Daniel; Drummey, Kristen; Franks, Kevin M; Panzeri, Stefano; Datta, Sandeep Robert.
In: NATURE, Vol. 583, No. 7815, 07.2020, p. 253-258.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Structure and flexibility in cortical representations of odour space
AU - Pashkovski, Stan L
AU - Iurilli, Giuliano
AU - Brann, David
AU - Chicharro, Daniel
AU - Drummey, Kristen
AU - Franks, Kevin M
AU - Panzeri, Stefano
AU - Datta, Sandeep Robert
PY - 2020/7
Y1 - 2020/7
N2 - The cortex organizes sensory information to enable discrimination and generalization1-4. As systematic representations of chemical odour space have not yet been described in the olfactory cortex, it remains unclear how odour relationships are encoded to place chemically distinct but similar odours, such as lemon and orange, into perceptual categories, such as citrus5-7. Here, by combining chemoinformatics and multiphoton imaging in the mouse, we show that both the piriform cortex and its sensory inputs from the olfactory bulb represent chemical odour relationships through correlated patterns of activity. However, cortical odour codes differ from those in the bulb: cortex more strongly clusters together representations for related odours, selectively rewrites pairwise odour relationships, and better matches odour perception. The bulb-to-cortex transformation depends on the associative network originating within the piriform cortex, and can be reshaped by passive odour experience. Thus, cortex actively builds a structured representation of chemical odour space that highlights odour relationships; this representation is similar across individuals but remains plastic, suggesting a means through which the olfactory system can assign related odour cues to common and yet personalized percepts.
AB - The cortex organizes sensory information to enable discrimination and generalization1-4. As systematic representations of chemical odour space have not yet been described in the olfactory cortex, it remains unclear how odour relationships are encoded to place chemically distinct but similar odours, such as lemon and orange, into perceptual categories, such as citrus5-7. Here, by combining chemoinformatics and multiphoton imaging in the mouse, we show that both the piriform cortex and its sensory inputs from the olfactory bulb represent chemical odour relationships through correlated patterns of activity. However, cortical odour codes differ from those in the bulb: cortex more strongly clusters together representations for related odours, selectively rewrites pairwise odour relationships, and better matches odour perception. The bulb-to-cortex transformation depends on the associative network originating within the piriform cortex, and can be reshaped by passive odour experience. Thus, cortex actively builds a structured representation of chemical odour space that highlights odour relationships; this representation is similar across individuals but remains plastic, suggesting a means through which the olfactory system can assign related odour cues to common and yet personalized percepts.
KW - Animals
KW - Male
KW - Mice
KW - Odorants/analysis
KW - Olfactory Bulb/cytology
KW - Olfactory Cortex/anatomy & histology
KW - Olfactory Pathways
KW - Olfactory Perception/physiology
KW - Organic Chemicals/analysis
KW - Smell
U2 - 10.1038/s41586-020-2451-1
DO - 10.1038/s41586-020-2451-1
M3 - SCORING: Journal article
C2 - 32612230
VL - 583
SP - 253
EP - 258
JO - NATURE
JF - NATURE
SN - 0028-0836
IS - 7815
ER -