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Structural brain correlates of adolescent resilience

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Structural brain correlates of adolescent resilience. / Burt, Keith B; Whelan, Robert; Conrod, Patricia J; Banaschewski, Tobias; Barker, Gareth J; Bokde, Arun L W; Bromberg, Uli; Büchel, Christian; Fauth-Bühler, Mira; Flor, Herta; Galinowski, André; Gallinat, Juergen; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Mann, Karl; Nees, Frauke; Papadopoulos-Orfanos, Dimitri; Paus, Tomas; Pausova, Zdenka; Poustka, Luise; Rietschel, Marcella; Robbins, Trevor W; Smolka, Michael N; Ströhle, Andreas; Schumann, Gunter; Garavan, Hugh; IMAGEN Consortium.

In: J CHILD PSYCHOL PSYC, Vol. 57, No. 11, 15.04.2016, p. 1287-1296.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Burt, KB, Whelan, R, Conrod, PJ, Banaschewski, T, Barker, GJ, Bokde, ALW, Bromberg, U, Büchel, C, Fauth-Bühler, M, Flor, H, Galinowski, A, Gallinat, J, Gowland, P, Heinz, A, Ittermann, B, Mann, K, Nees, F, Papadopoulos-Orfanos, D, Paus, T, Pausova, Z, Poustka, L, Rietschel, M, Robbins, TW, Smolka, MN, Ströhle, A, Schumann, G, Garavan, H & IMAGEN Consortium 2016, 'Structural brain correlates of adolescent resilience', J CHILD PSYCHOL PSYC, vol. 57, no. 11, pp. 1287-1296. https://doi.org/10.1111/jcpp.12552

APA

Burt, K. B., Whelan, R., Conrod, P. J., Banaschewski, T., Barker, G. J., Bokde, A. L. W., Bromberg, U., Büchel, C., Fauth-Bühler, M., Flor, H., Galinowski, A., Gallinat, J., Gowland, P., Heinz, A., Ittermann, B., Mann, K., Nees, F., Papadopoulos-Orfanos, D., Paus, T., ... IMAGEN Consortium (2016). Structural brain correlates of adolescent resilience. J CHILD PSYCHOL PSYC, 57(11), 1287-1296. https://doi.org/10.1111/jcpp.12552

Vancouver

Burt KB, Whelan R, Conrod PJ, Banaschewski T, Barker GJ, Bokde ALW et al. Structural brain correlates of adolescent resilience. J CHILD PSYCHOL PSYC. 2016 Apr 15;57(11):1287-1296. https://doi.org/10.1111/jcpp.12552

Bibtex

@article{17bad284b5334892b2dcede5877184e8,
title = "Structural brain correlates of adolescent resilience",
abstract = "BACKGROUND: Despite calls for integration of neurobiological methods into research on youth resilience (high competence despite high adversity), we know little about structural brain correlates of resilient functioning. The aim of the current study was to test for brain regions uniquely associated with positive functioning in the context of adversity, using detailed phenotypic classification.METHODS: 1,870 European adolescents (Mage = 14.56 years, SDage = 0.44 years, 51.5% female) underwent MRI scanning and completed behavioral and psychological measures of stressful life events, academic competence, social competence, rule-abiding conduct, personality, and alcohol use.RESULTS: The interaction of competence and adversity identified two regions centered on the right middle and superior frontal gyri; grey matter volumes in these regions were larger in adolescents experiencing adversity who showed positive adaptation. Differences in these regions among competence/adversity subgroups were maintained after controlling for several covariates and were robust to alternative operationalization decisions for key constructs.CONCLUSIONS: We demonstrate structural brain correlates of adolescent resilience, and suggest that right prefrontal structures are implicated in adaptive functioning for youth who have experienced adversity.",
author = "Burt, {Keith B} and Robert Whelan and Conrod, {Patricia J} and Tobias Banaschewski and Barker, {Gareth J} and Bokde, {Arun L W} and Uli Bromberg and Christian B{\"u}chel and Mira Fauth-B{\"u}hler and Herta Flor and Andr{\'e} Galinowski and Juergen Gallinat and Penny Gowland and Andreas Heinz and Bernd Ittermann and Karl Mann and Frauke Nees and Dimitri Papadopoulos-Orfanos and Tomas Paus and Zdenka Pausova and Luise Poustka and Marcella Rietschel and Robbins, {Trevor W} and Smolka, {Michael N} and Andreas Str{\"o}hle and Gunter Schumann and Hugh Garavan and {IMAGEN Consortium}",
note = "{\textcopyright} 2016 Association for Child and Adolescent Mental Health.",
year = "2016",
month = apr,
day = "15",
doi = "10.1111/jcpp.12552",
language = "English",
volume = "57",
pages = "1287--1296",
journal = "J CHILD PSYCHOL PSYC",
issn = "0021-9630",
publisher = "Wiley-Blackwell",
number = "11",

}

RIS

TY - JOUR

T1 - Structural brain correlates of adolescent resilience

AU - Burt, Keith B

AU - Whelan, Robert

AU - Conrod, Patricia J

AU - Banaschewski, Tobias

AU - Barker, Gareth J

AU - Bokde, Arun L W

AU - Bromberg, Uli

AU - Büchel, Christian

AU - Fauth-Bühler, Mira

AU - Flor, Herta

AU - Galinowski, André

AU - Gallinat, Juergen

AU - Gowland, Penny

AU - Heinz, Andreas

AU - Ittermann, Bernd

AU - Mann, Karl

AU - Nees, Frauke

AU - Papadopoulos-Orfanos, Dimitri

AU - Paus, Tomas

AU - Pausova, Zdenka

AU - Poustka, Luise

AU - Rietschel, Marcella

AU - Robbins, Trevor W

AU - Smolka, Michael N

AU - Ströhle, Andreas

AU - Schumann, Gunter

AU - Garavan, Hugh

AU - IMAGEN Consortium

N1 - © 2016 Association for Child and Adolescent Mental Health.

PY - 2016/4/15

Y1 - 2016/4/15

N2 - BACKGROUND: Despite calls for integration of neurobiological methods into research on youth resilience (high competence despite high adversity), we know little about structural brain correlates of resilient functioning. The aim of the current study was to test for brain regions uniquely associated with positive functioning in the context of adversity, using detailed phenotypic classification.METHODS: 1,870 European adolescents (Mage = 14.56 years, SDage = 0.44 years, 51.5% female) underwent MRI scanning and completed behavioral and psychological measures of stressful life events, academic competence, social competence, rule-abiding conduct, personality, and alcohol use.RESULTS: The interaction of competence and adversity identified two regions centered on the right middle and superior frontal gyri; grey matter volumes in these regions were larger in adolescents experiencing adversity who showed positive adaptation. Differences in these regions among competence/adversity subgroups were maintained after controlling for several covariates and were robust to alternative operationalization decisions for key constructs.CONCLUSIONS: We demonstrate structural brain correlates of adolescent resilience, and suggest that right prefrontal structures are implicated in adaptive functioning for youth who have experienced adversity.

AB - BACKGROUND: Despite calls for integration of neurobiological methods into research on youth resilience (high competence despite high adversity), we know little about structural brain correlates of resilient functioning. The aim of the current study was to test for brain regions uniquely associated with positive functioning in the context of adversity, using detailed phenotypic classification.METHODS: 1,870 European adolescents (Mage = 14.56 years, SDage = 0.44 years, 51.5% female) underwent MRI scanning and completed behavioral and psychological measures of stressful life events, academic competence, social competence, rule-abiding conduct, personality, and alcohol use.RESULTS: The interaction of competence and adversity identified two regions centered on the right middle and superior frontal gyri; grey matter volumes in these regions were larger in adolescents experiencing adversity who showed positive adaptation. Differences in these regions among competence/adversity subgroups were maintained after controlling for several covariates and were robust to alternative operationalization decisions for key constructs.CONCLUSIONS: We demonstrate structural brain correlates of adolescent resilience, and suggest that right prefrontal structures are implicated in adaptive functioning for youth who have experienced adversity.

U2 - 10.1111/jcpp.12552

DO - 10.1111/jcpp.12552

M3 - SCORING: Journal article

C2 - 27079174

VL - 57

SP - 1287

EP - 1296

JO - J CHILD PSYCHOL PSYC

JF - J CHILD PSYCHOL PSYC

SN - 0021-9630

IS - 11

ER -