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Structural brain changes related to disease duration in patients with asthma.

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Structural brain changes related to disease duration in patients with asthma. / Von Leupoldt, Andreas; Brassen, Stefanie; Baumann, Hans Jörg; Klose, Hans; Büchel, Christian.

In: PLOS ONE, Vol. 6, No. 8, 8, 2011, p. 23739.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Von Leupoldt, A, Brassen, S, Baumann, HJ, Klose, H & Büchel, C 2011, 'Structural brain changes related to disease duration in patients with asthma.', PLOS ONE, vol. 6, no. 8, 8, pp. 23739. https://doi.org/10.1371/journal.pone.0023739

APA

Von Leupoldt, A., Brassen, S., Baumann, H. J., Klose, H., & Büchel, C. (2011). Structural brain changes related to disease duration in patients with asthma. PLOS ONE, 6(8), 23739. [8]. https://doi.org/10.1371/journal.pone.0023739

Vancouver

Von Leupoldt A, Brassen S, Baumann HJ, Klose H, Büchel C. Structural brain changes related to disease duration in patients with asthma. PLOS ONE. 2011;6(8):23739. 8. https://doi.org/10.1371/journal.pone.0023739

Bibtex

@article{f88bc6cb78804a2a84fd7d6e0e2c85b8,
title = "Structural brain changes related to disease duration in patients with asthma.",
abstract = "Dyspnea is the impairing, cardinal symptom patients with asthma repeatedly experience over the course of the disease. However, its accurate perception is also crucial for timely initiation of treatment. Reduced perception of dyspnea is associated with negative treatment outcome, but the underlying brain mechanisms of perceived dyspnea in patients with asthma remain poorly understood. We examined whether increasing disease duration in fourteen patients with mild-to-moderate asthma is related to structural brain changes in the insular cortex and brainstem periaqueductal grey (PAG). In addition, the association between structural brain changes and perceived dyspnea were studied. By using magnetic resonance imaging in combination with voxel-based morphometry, gray matter volumes of the insular cortex and the PAG were analysed and correlated with asthma duration and perceived affective unpleasantness of resistive load induced dyspnea. Whereas no associations were observed for the insular cortex, longer duration of asthma was associated with increased gray matter volume in the PAG. Moreover, increased PAG gray matter volume was related to reduced ratings of dyspnea unpleasantness. Our results demonstrate that increasing disease duration is associated with increased gray matter volume in the brainstem PAG in patients with mild-to-moderate asthma. This structural brain change might contribute to the reduced perception of dyspnea in some patients with asthma and negatively impact the treatment outcome.",
keywords = "Adult, Humans, Male, Female, Young Adult, Time Factors, Disease Progression, Case-Control Studies, Brain/*pathology, Asthma/*complications/pathology, Brain Diseases/etiology, Cerebral Cortex, Dyspnea/etiology, Magnetic Resonance Imaging/methods, *Neuroimaging, Periaqueductal Gray, Adult, Humans, Male, Female, Young Adult, Time Factors, Disease Progression, Case-Control Studies, Brain/*pathology, Asthma/*complications/pathology, Brain Diseases/etiology, Cerebral Cortex, Dyspnea/etiology, Magnetic Resonance Imaging/methods, *Neuroimaging, Periaqueductal Gray",
author = "{Von Leupoldt}, Andreas and Stefanie Brassen and Baumann, {Hans J{\"o}rg} and Hans Klose and Christian B{\"u}chel",
year = "2011",
doi = "10.1371/journal.pone.0023739",
language = "English",
volume = "6",
pages = "23739",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "8",

}

RIS

TY - JOUR

T1 - Structural brain changes related to disease duration in patients with asthma.

AU - Von Leupoldt, Andreas

AU - Brassen, Stefanie

AU - Baumann, Hans Jörg

AU - Klose, Hans

AU - Büchel, Christian

PY - 2011

Y1 - 2011

N2 - Dyspnea is the impairing, cardinal symptom patients with asthma repeatedly experience over the course of the disease. However, its accurate perception is also crucial for timely initiation of treatment. Reduced perception of dyspnea is associated with negative treatment outcome, but the underlying brain mechanisms of perceived dyspnea in patients with asthma remain poorly understood. We examined whether increasing disease duration in fourteen patients with mild-to-moderate asthma is related to structural brain changes in the insular cortex and brainstem periaqueductal grey (PAG). In addition, the association between structural brain changes and perceived dyspnea were studied. By using magnetic resonance imaging in combination with voxel-based morphometry, gray matter volumes of the insular cortex and the PAG were analysed and correlated with asthma duration and perceived affective unpleasantness of resistive load induced dyspnea. Whereas no associations were observed for the insular cortex, longer duration of asthma was associated with increased gray matter volume in the PAG. Moreover, increased PAG gray matter volume was related to reduced ratings of dyspnea unpleasantness. Our results demonstrate that increasing disease duration is associated with increased gray matter volume in the brainstem PAG in patients with mild-to-moderate asthma. This structural brain change might contribute to the reduced perception of dyspnea in some patients with asthma and negatively impact the treatment outcome.

AB - Dyspnea is the impairing, cardinal symptom patients with asthma repeatedly experience over the course of the disease. However, its accurate perception is also crucial for timely initiation of treatment. Reduced perception of dyspnea is associated with negative treatment outcome, but the underlying brain mechanisms of perceived dyspnea in patients with asthma remain poorly understood. We examined whether increasing disease duration in fourteen patients with mild-to-moderate asthma is related to structural brain changes in the insular cortex and brainstem periaqueductal grey (PAG). In addition, the association between structural brain changes and perceived dyspnea were studied. By using magnetic resonance imaging in combination with voxel-based morphometry, gray matter volumes of the insular cortex and the PAG were analysed and correlated with asthma duration and perceived affective unpleasantness of resistive load induced dyspnea. Whereas no associations were observed for the insular cortex, longer duration of asthma was associated with increased gray matter volume in the PAG. Moreover, increased PAG gray matter volume was related to reduced ratings of dyspnea unpleasantness. Our results demonstrate that increasing disease duration is associated with increased gray matter volume in the brainstem PAG in patients with mild-to-moderate asthma. This structural brain change might contribute to the reduced perception of dyspnea in some patients with asthma and negatively impact the treatment outcome.

KW - Adult

KW - Humans

KW - Male

KW - Female

KW - Young Adult

KW - Time Factors

KW - Disease Progression

KW - Case-Control Studies

KW - Brain/pathology

KW - Asthma/complications/pathology

KW - Brain Diseases/etiology

KW - Cerebral Cortex

KW - Dyspnea/etiology

KW - Magnetic Resonance Imaging/methods

KW - Neuroimaging

KW - Periaqueductal Gray

KW - Adult

KW - Humans

KW - Male

KW - Female

KW - Young Adult

KW - Time Factors

KW - Disease Progression

KW - Case-Control Studies

KW - Brain/pathology

KW - Asthma/complications/pathology

KW - Brain Diseases/etiology

KW - Cerebral Cortex

KW - Dyspnea/etiology

KW - Magnetic Resonance Imaging/methods

KW - Neuroimaging

KW - Periaqueductal Gray

U2 - 10.1371/journal.pone.0023739

DO - 10.1371/journal.pone.0023739

M3 - SCORING: Journal article

VL - 6

SP - 23739

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 8

M1 - 8

ER -