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Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy.

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Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy. / Yekebas, Emre-F; Bogoevski, Dean; Bubenheim, Michael; Link, Björn-Christian; Kaifi, Jussuf; Wachowiak, Robin; Mann, Oliver; Kutup, Asad; Cataldegirmen, Guellue; Wolfram, Lars; Erbersdobler, Andreas; Klein, Christoph; Pantel, Klaus; Izbicki, Jakob R.

In: WORLD J GASTROENTERO, Vol. 12, No. 40, 40, 2006, p. 6515-6521.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Yekebas, E-F, Bogoevski, D, Bubenheim, M, Link, B-C, Kaifi, J, Wachowiak, R, Mann, O, Kutup, A, Cataldegirmen, G, Wolfram, L, Erbersdobler, A, Klein, C, Pantel, K & Izbicki, JR 2006, 'Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy.', WORLD J GASTROENTERO, vol. 12, no. 40, 40, pp. 6515-6521. <http://www.ncbi.nlm.nih.gov/pubmed/17072983?dopt=Citation>

APA

Yekebas, E-F., Bogoevski, D., Bubenheim, M., Link, B-C., Kaifi, J., Wachowiak, R., Mann, O., Kutup, A., Cataldegirmen, G., Wolfram, L., Erbersdobler, A., Klein, C., Pantel, K., & Izbicki, J. R. (2006). Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy. WORLD J GASTROENTERO, 12(40), 6515-6521. [40]. http://www.ncbi.nlm.nih.gov/pubmed/17072983?dopt=Citation

Vancouver

Yekebas E-F, Bogoevski D, Bubenheim M, Link B-C, Kaifi J, Wachowiak R et al. Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy. WORLD J GASTROENTERO. 2006;12(40):6515-6521. 40.

Bibtex

@article{ab1a7bf1d2154cbe8b363b9c71750419,
title = "Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy.",
abstract = "AIM: To study the prognostic value of adjuvant chemotherapy in patients with pancreatic, ductal adenocarcinoma. METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT((1/2)), 63 (59%) as pT((3/4)), 51 (48%) as pN(0), and 55 (52%) as pN(1). The study population included 59 (56%) patients exhibiting G((1/2)), and 47 (44%) patients with G(3) tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo. RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as {"}tumor free{"} by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%) of 51 patients staged histopathologically as pN(0) had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P=0.005) and overall (relative risk 2.49, P=0.009) survival. CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer.",
author = "Emre-F Yekebas and Dean Bogoevski and Michael Bubenheim and Bj{\"o}rn-Christian Link and Jussuf Kaifi and Robin Wachowiak and Oliver Mann and Asad Kutup and Guellue Cataldegirmen and Lars Wolfram and Andreas Erbersdobler and Christoph Klein and Klaus Pantel and Izbicki, {Jakob R.}",
year = "2006",
language = "Deutsch",
volume = "12",
pages = "6515--6521",
journal = "WORLD J GASTROENTERO",
issn = "1007-9327",
publisher = "WJG Press",
number = "40",

}

RIS

TY - JOUR

T1 - Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy.

AU - Yekebas, Emre-F

AU - Bogoevski, Dean

AU - Bubenheim, Michael

AU - Link, Björn-Christian

AU - Kaifi, Jussuf

AU - Wachowiak, Robin

AU - Mann, Oliver

AU - Kutup, Asad

AU - Cataldegirmen, Guellue

AU - Wolfram, Lars

AU - Erbersdobler, Andreas

AU - Klein, Christoph

AU - Pantel, Klaus

AU - Izbicki, Jakob R.

PY - 2006

Y1 - 2006

N2 - AIM: To study the prognostic value of adjuvant chemotherapy in patients with pancreatic, ductal adenocarcinoma. METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT((1/2)), 63 (59%) as pT((3/4)), 51 (48%) as pN(0), and 55 (52%) as pN(1). The study population included 59 (56%) patients exhibiting G((1/2)), and 47 (44%) patients with G(3) tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo. RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as "tumor free" by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%) of 51 patients staged histopathologically as pN(0) had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P=0.005) and overall (relative risk 2.49, P=0.009) survival. CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer.

AB - AIM: To study the prognostic value of adjuvant chemotherapy in patients with pancreatic, ductal adenocarcinoma. METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT((1/2)), 63 (59%) as pT((3/4)), 51 (48%) as pN(0), and 55 (52%) as pN(1). The study population included 59 (56%) patients exhibiting G((1/2)), and 47 (44%) patients with G(3) tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo. RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as "tumor free" by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%) of 51 patients staged histopathologically as pN(0) had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P=0.005) and overall (relative risk 2.49, P=0.009) survival. CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer.

M3 - SCORING: Zeitschriftenaufsatz

VL - 12

SP - 6515

EP - 6521

JO - WORLD J GASTROENTERO

JF - WORLD J GASTROENTERO

SN - 1007-9327

IS - 40

M1 - 40

ER -