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Stroke Etiology Modifies the Effect of Endovascular Treatment in Acute Stroke

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Stroke Etiology Modifies the Effect of Endovascular Treatment in Acute Stroke. / Tiedt, Steffen; Herzberg, Moriz; Küpper, Clemens; Feil, Katharina; Kellert, Lars; Dorn, Franziska; Liebig, Thomas; Alegiani, Anna; Dichgans, Martin; Wollenweber, Frank A; GSR investigators.

In: STROKE, Vol. 51, No. 3, 03.2020, p. 1014-1016.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Tiedt, S, Herzberg, M, Küpper, C, Feil, K, Kellert, L, Dorn, F, Liebig, T, Alegiani, A, Dichgans, M, Wollenweber, FA & GSR investigators 2020, 'Stroke Etiology Modifies the Effect of Endovascular Treatment in Acute Stroke', STROKE, vol. 51, no. 3, pp. 1014-1016. https://doi.org/10.1161/STROKEAHA.119.028383

APA

Tiedt, S., Herzberg, M., Küpper, C., Feil, K., Kellert, L., Dorn, F., Liebig, T., Alegiani, A., Dichgans, M., Wollenweber, F. A., & GSR investigators (2020). Stroke Etiology Modifies the Effect of Endovascular Treatment in Acute Stroke. STROKE, 51(3), 1014-1016. https://doi.org/10.1161/STROKEAHA.119.028383

Vancouver

Tiedt S, Herzberg M, Küpper C, Feil K, Kellert L, Dorn F et al. Stroke Etiology Modifies the Effect of Endovascular Treatment in Acute Stroke. STROKE. 2020 Mar;51(3):1014-1016. https://doi.org/10.1161/STROKEAHA.119.028383

Bibtex

@article{daa7a0fc52e64ce7bab0ac8e4d1d9910,
title = "Stroke Etiology Modifies the Effect of Endovascular Treatment in Acute Stroke",
abstract = "Background and Purpose- Stroke etiology drives thrombus composition. We thus hypothesized that endovascular treatment shows different efficacy in cardioembolic versus noncardioembolic large-vessel occlusions (LVOs). Methods- Procedural characteristics, grade of reperfusion, and functional outcome at discharge and 90 days were compared between patients with cardioembolic versus noncardioembolic LVO from the GSR-ET (German Stroke Registry-Endovascular Treatment; n=2589). To determine associations with functional outcome, adjusted odds ratios and 95% CIs were calculated using ordinal multivariable logistic regression models adjusting for potential baseline confounder variables. Results- Endovascular treatment of cardioembolic LVO had a higher rate of successful reperfusion (85.6% versus 81.0%; P=0.002) and a higher rate of complete reperfusion after a single thrombectomy pass (45.7% versus 38.1%; P<0.001) compared with noncardioembolic LVO. Cardioembolic LVO was associated with better functional outcome at discharge (adjusted odds ratio, 1.61 [95% CI, 1.37-1.88]) and 90 days (adjusted odds ratio, 1.29 [95% CI, 1.09-1.53]). In mediation analysis, reperfusion explained 47% of the effect of etiology on functional outcome at discharge. Conclusions- These results provide evidence for higher efficacy of endovascular treatment in cardioembolic LVO compared with noncardioembolic LVO.",
keywords = "Aged, Aged, 80 and over, Endovascular Procedures, Female, Humans, Intracranial Embolism/epidemiology, Male, Middle Aged, Registries, Stroke/epidemiology, Thrombectomy",
author = "Steffen Tiedt and Moriz Herzberg and Clemens K{\"u}pper and Katharina Feil and Lars Kellert and Franziska Dorn and Thomas Liebig and Anna Alegiani and Martin Dichgans and Wollenweber, {Frank A} and {GSR investigators} and Jens Fiehler and Flottmann, {Fabian Alexander} and Christian Gerloff and G{\"o}tz Thomalla",
year = "2020",
month = mar,
doi = "10.1161/STROKEAHA.119.028383",
language = "English",
volume = "51",
pages = "1014--1016",
journal = "STROKE",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

RIS

TY - JOUR

T1 - Stroke Etiology Modifies the Effect of Endovascular Treatment in Acute Stroke

AU - Tiedt, Steffen

AU - Herzberg, Moriz

AU - Küpper, Clemens

AU - Feil, Katharina

AU - Kellert, Lars

AU - Dorn, Franziska

AU - Liebig, Thomas

AU - Alegiani, Anna

AU - Dichgans, Martin

AU - Wollenweber, Frank A

AU - GSR investigators

AU - Fiehler, Jens

AU - Flottmann, Fabian Alexander

AU - Gerloff, Christian

AU - Thomalla, Götz

PY - 2020/3

Y1 - 2020/3

N2 - Background and Purpose- Stroke etiology drives thrombus composition. We thus hypothesized that endovascular treatment shows different efficacy in cardioembolic versus noncardioembolic large-vessel occlusions (LVOs). Methods- Procedural characteristics, grade of reperfusion, and functional outcome at discharge and 90 days were compared between patients with cardioembolic versus noncardioembolic LVO from the GSR-ET (German Stroke Registry-Endovascular Treatment; n=2589). To determine associations with functional outcome, adjusted odds ratios and 95% CIs were calculated using ordinal multivariable logistic regression models adjusting for potential baseline confounder variables. Results- Endovascular treatment of cardioembolic LVO had a higher rate of successful reperfusion (85.6% versus 81.0%; P=0.002) and a higher rate of complete reperfusion after a single thrombectomy pass (45.7% versus 38.1%; P<0.001) compared with noncardioembolic LVO. Cardioembolic LVO was associated with better functional outcome at discharge (adjusted odds ratio, 1.61 [95% CI, 1.37-1.88]) and 90 days (adjusted odds ratio, 1.29 [95% CI, 1.09-1.53]). In mediation analysis, reperfusion explained 47% of the effect of etiology on functional outcome at discharge. Conclusions- These results provide evidence for higher efficacy of endovascular treatment in cardioembolic LVO compared with noncardioembolic LVO.

AB - Background and Purpose- Stroke etiology drives thrombus composition. We thus hypothesized that endovascular treatment shows different efficacy in cardioembolic versus noncardioembolic large-vessel occlusions (LVOs). Methods- Procedural characteristics, grade of reperfusion, and functional outcome at discharge and 90 days were compared between patients with cardioembolic versus noncardioembolic LVO from the GSR-ET (German Stroke Registry-Endovascular Treatment; n=2589). To determine associations with functional outcome, adjusted odds ratios and 95% CIs were calculated using ordinal multivariable logistic regression models adjusting for potential baseline confounder variables. Results- Endovascular treatment of cardioembolic LVO had a higher rate of successful reperfusion (85.6% versus 81.0%; P=0.002) and a higher rate of complete reperfusion after a single thrombectomy pass (45.7% versus 38.1%; P<0.001) compared with noncardioembolic LVO. Cardioembolic LVO was associated with better functional outcome at discharge (adjusted odds ratio, 1.61 [95% CI, 1.37-1.88]) and 90 days (adjusted odds ratio, 1.29 [95% CI, 1.09-1.53]). In mediation analysis, reperfusion explained 47% of the effect of etiology on functional outcome at discharge. Conclusions- These results provide evidence for higher efficacy of endovascular treatment in cardioembolic LVO compared with noncardioembolic LVO.

KW - Aged

KW - Aged, 80 and over

KW - Endovascular Procedures

KW - Female

KW - Humans

KW - Intracranial Embolism/epidemiology

KW - Male

KW - Middle Aged

KW - Registries

KW - Stroke/epidemiology

KW - Thrombectomy

U2 - 10.1161/STROKEAHA.119.028383

DO - 10.1161/STROKEAHA.119.028383

M3 - SCORING: Journal article

C2 - 31847752

VL - 51

SP - 1014

EP - 1016

JO - STROKE

JF - STROKE

SN - 0039-2499

IS - 3

ER -