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Stroke and left atrial thrombi after cryoballoon ablation of atrial fibrillation: incidence and predictors. Results from a long-term follow-up

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Stroke and left atrial thrombi after cryoballoon ablation of atrial fibrillation: incidence and predictors. Results from a long-term follow-up. / Santoro, Francesco; Brunetti, Natale Daniele; Rillig, Andreas; Reissmann, Bruno; Lemeš, Christine; Maurer, Tilman; Fink, Thomas; Hashiguchi, Naotaka; Leopizzi, Alessandra; Mallardi, Adriana; Mathew, Shibu; Ouyang, Feifan; Kuck, Karl-Heinz; Tilz, Roland R; Metzner, Andreas; Heeger, Christian H.

In: J THROMB THROMBOLYS, Vol. 51, No. 1, 01.2021, p. 74-80.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Santoro, F, Brunetti, ND, Rillig, A, Reissmann, B, Lemeš, C, Maurer, T, Fink, T, Hashiguchi, N, Leopizzi, A, Mallardi, A, Mathew, S, Ouyang, F, Kuck, K-H, Tilz, RR, Metzner, A & Heeger, CH 2021, 'Stroke and left atrial thrombi after cryoballoon ablation of atrial fibrillation: incidence and predictors. Results from a long-term follow-up', J THROMB THROMBOLYS, vol. 51, no. 1, pp. 74-80. https://doi.org/10.1007/s11239-020-02148-x

APA

Santoro, F., Brunetti, N. D., Rillig, A., Reissmann, B., Lemeš, C., Maurer, T., Fink, T., Hashiguchi, N., Leopizzi, A., Mallardi, A., Mathew, S., Ouyang, F., Kuck, K-H., Tilz, R. R., Metzner, A., & Heeger, C. H. (2021). Stroke and left atrial thrombi after cryoballoon ablation of atrial fibrillation: incidence and predictors. Results from a long-term follow-up. J THROMB THROMBOLYS, 51(1), 74-80. https://doi.org/10.1007/s11239-020-02148-x

Vancouver

Santoro F, Brunetti ND, Rillig A, Reissmann B, Lemeš C, Maurer T et al. Stroke and left atrial thrombi after cryoballoon ablation of atrial fibrillation: incidence and predictors. Results from a long-term follow-up. J THROMB THROMBOLYS. 2021 Jan;51(1):74-80. https://doi.org/10.1007/s11239-020-02148-x

Bibtex

@article{17a9c677a77548a3bcf4180a7a156b2b,
title = "Stroke and left atrial thrombi after cryoballoon ablation of atrial fibrillation: incidence and predictors. Results from a long-term follow-up",
abstract = "Stroke after catheter ablation (CA) of atrial fibrillation (AF) is a potential complication with long term consequences. Aim of this study was to determine incidence and potential predictors of stroke and left atrial appendage (LAA) thrombi after AF ablation with cryo-energy. Two hundred nine consecutive patients with symptomatic drug refractory AF (65% male; 61 ± 11 yo, 69% paroxysmal AF, mean CHA2DS2-VASc score 2 ± 1.4) were enrolled between October 2012 until December 2015. Long term follow-up was performed with outpatient clinic visits at 6-month intervals. Incidence of stroke after CA was 1.4% (3/209 pts) at long term follow-up. Two out of 3 pts experienced stroke during the first 3 month after CA and one after 36 months. At long term follow-up LAA thrombi were found in two patients (1%) that were on therapeutic oral anticoagulation. Recurrence of AF was found in 4 out of 5 pts with stroke or LAA thrombi. Patients with stroke or LAA thrombi did not differed from those without in term of age, gender, CV risk factors, LA size and AF type. They differed only for EHRA score (2.4 vs 1.3, p = 0.01) before CA. At multivariate analysis after correction for age, gender, LA size, LVEF and AF type, only EHRA score (β 1.92, 95% C.I. 1.3-35 p = 0.02), was an independent predictor of stroke/LAA thrombi. Incidence of stroke after cryoablation is low, with a relative higher prevalence during the first 3 months after CA. Prospective, multicenter long-term registries are needed for a better stroke risk stratification.",
keywords = "Aged, Atrial Appendage/pathology, Atrial Fibrillation/surgery, Cryosurgery/adverse effects, Female, Follow-Up Studies, Humans, Incidence, Male, Middle Aged, Prognosis, Stroke/diagnosis, Thrombosis/diagnosis",
author = "Francesco Santoro and Brunetti, {Natale Daniele} and Andreas Rillig and Bruno Reissmann and Christine Leme{\v s} and Tilman Maurer and Thomas Fink and Naotaka Hashiguchi and Alessandra Leopizzi and Adriana Mallardi and Shibu Mathew and Feifan Ouyang and Karl-Heinz Kuck and Tilz, {Roland R} and Andreas Metzner and Heeger, {Christian H}",
year = "2021",
month = jan,
doi = "10.1007/s11239-020-02148-x",
language = "English",
volume = "51",
pages = "74--80",
journal = "J THROMB THROMBOLYS",
issn = "0929-5305",
publisher = "Springer Netherlands",
number = "1",

}

RIS

TY - JOUR

T1 - Stroke and left atrial thrombi after cryoballoon ablation of atrial fibrillation: incidence and predictors. Results from a long-term follow-up

AU - Santoro, Francesco

AU - Brunetti, Natale Daniele

AU - Rillig, Andreas

AU - Reissmann, Bruno

AU - Lemeš, Christine

AU - Maurer, Tilman

AU - Fink, Thomas

AU - Hashiguchi, Naotaka

AU - Leopizzi, Alessandra

AU - Mallardi, Adriana

AU - Mathew, Shibu

AU - Ouyang, Feifan

AU - Kuck, Karl-Heinz

AU - Tilz, Roland R

AU - Metzner, Andreas

AU - Heeger, Christian H

PY - 2021/1

Y1 - 2021/1

N2 - Stroke after catheter ablation (CA) of atrial fibrillation (AF) is a potential complication with long term consequences. Aim of this study was to determine incidence and potential predictors of stroke and left atrial appendage (LAA) thrombi after AF ablation with cryo-energy. Two hundred nine consecutive patients with symptomatic drug refractory AF (65% male; 61 ± 11 yo, 69% paroxysmal AF, mean CHA2DS2-VASc score 2 ± 1.4) were enrolled between October 2012 until December 2015. Long term follow-up was performed with outpatient clinic visits at 6-month intervals. Incidence of stroke after CA was 1.4% (3/209 pts) at long term follow-up. Two out of 3 pts experienced stroke during the first 3 month after CA and one after 36 months. At long term follow-up LAA thrombi were found in two patients (1%) that were on therapeutic oral anticoagulation. Recurrence of AF was found in 4 out of 5 pts with stroke or LAA thrombi. Patients with stroke or LAA thrombi did not differed from those without in term of age, gender, CV risk factors, LA size and AF type. They differed only for EHRA score (2.4 vs 1.3, p = 0.01) before CA. At multivariate analysis after correction for age, gender, LA size, LVEF and AF type, only EHRA score (β 1.92, 95% C.I. 1.3-35 p = 0.02), was an independent predictor of stroke/LAA thrombi. Incidence of stroke after cryoablation is low, with a relative higher prevalence during the first 3 months after CA. Prospective, multicenter long-term registries are needed for a better stroke risk stratification.

AB - Stroke after catheter ablation (CA) of atrial fibrillation (AF) is a potential complication with long term consequences. Aim of this study was to determine incidence and potential predictors of stroke and left atrial appendage (LAA) thrombi after AF ablation with cryo-energy. Two hundred nine consecutive patients with symptomatic drug refractory AF (65% male; 61 ± 11 yo, 69% paroxysmal AF, mean CHA2DS2-VASc score 2 ± 1.4) were enrolled between October 2012 until December 2015. Long term follow-up was performed with outpatient clinic visits at 6-month intervals. Incidence of stroke after CA was 1.4% (3/209 pts) at long term follow-up. Two out of 3 pts experienced stroke during the first 3 month after CA and one after 36 months. At long term follow-up LAA thrombi were found in two patients (1%) that were on therapeutic oral anticoagulation. Recurrence of AF was found in 4 out of 5 pts with stroke or LAA thrombi. Patients with stroke or LAA thrombi did not differed from those without in term of age, gender, CV risk factors, LA size and AF type. They differed only for EHRA score (2.4 vs 1.3, p = 0.01) before CA. At multivariate analysis after correction for age, gender, LA size, LVEF and AF type, only EHRA score (β 1.92, 95% C.I. 1.3-35 p = 0.02), was an independent predictor of stroke/LAA thrombi. Incidence of stroke after cryoablation is low, with a relative higher prevalence during the first 3 months after CA. Prospective, multicenter long-term registries are needed for a better stroke risk stratification.

KW - Aged

KW - Atrial Appendage/pathology

KW - Atrial Fibrillation/surgery

KW - Cryosurgery/adverse effects

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Prognosis

KW - Stroke/diagnosis

KW - Thrombosis/diagnosis

U2 - 10.1007/s11239-020-02148-x

DO - 10.1007/s11239-020-02148-x

M3 - SCORING: Journal article

C2 - 32447744

VL - 51

SP - 74

EP - 80

JO - J THROMB THROMBOLYS

JF - J THROMB THROMBOLYS

SN - 0929-5305

IS - 1

ER -