Stress increases VCAM-1 expression at the fetomaternal interface in an abortion-prone mouse model.
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Stress increases VCAM-1 expression at the fetomaternal interface in an abortion-prone mouse model. / Prados, M B; Solano, Maria Emilia; Friebe, A; Blois, S; Arck, Petra; Miranda, S.
In: J REPROD IMMUNOL, Vol. 89, No. 2, 2, 2011, p. 207-211.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Stress increases VCAM-1 expression at the fetomaternal interface in an abortion-prone mouse model.
AU - Prados, M B
AU - Solano, Maria Emilia
AU - Friebe, A
AU - Blois, S
AU - Arck, Petra
AU - Miranda, S
PY - 2011
Y1 - 2011
N2 - Sound stress exposure increases fetal loss via inflammatory pathways. Inflammation is known to up-regulate cell adhesion molecules, such as vascular cell adhesion molecule-1 (VCAM-1), which mediates the adhesion of leukocytes to the vascular endothelium. In this work, we studied the frequency of VCAM-1(+) vessels at the fetomaternal interface in stressed and non-stressed pregnant CBA/J female mice mated with DBA/2J (high fetal loss model) or BALB/c (low fetal loss model) males. The high fetal loss model had fewer large vessels on gestation day 6.5, and stress reduced the frequency of large vessels to a similar number in both high and low fetal loss models. In the high fetal loss model, however, the frequency of VCAM-1+ vessels was dramatically increased. This study shows that VCAM-1 expression is modulated by stress at the fetomaternal interface in abortion-prone cross-breeding.
AB - Sound stress exposure increases fetal loss via inflammatory pathways. Inflammation is known to up-regulate cell adhesion molecules, such as vascular cell adhesion molecule-1 (VCAM-1), which mediates the adhesion of leukocytes to the vascular endothelium. In this work, we studied the frequency of VCAM-1(+) vessels at the fetomaternal interface in stressed and non-stressed pregnant CBA/J female mice mated with DBA/2J (high fetal loss model) or BALB/c (low fetal loss model) males. The high fetal loss model had fewer large vessels on gestation day 6.5, and stress reduced the frequency of large vessels to a similar number in both high and low fetal loss models. In the high fetal loss model, however, the frequency of VCAM-1+ vessels was dramatically increased. This study shows that VCAM-1 expression is modulated by stress at the fetomaternal interface in abortion-prone cross-breeding.
KW - Animals
KW - Male
KW - Female
KW - Mice
KW - Mice, Inbred BALB C
KW - Pregnancy
KW - Gene Expression Regulation
KW - Stress, Physiological
KW - Abortion, Spontaneous/metabolism/pathology
KW - Mice, Inbred CBA
KW - Placenta/metabolism/pathology
KW - Vascular Cell Adhesion Molecule-1/biosynthesis
KW - Animals
KW - Male
KW - Female
KW - Mice
KW - Mice, Inbred BALB C
KW - Pregnancy
KW - Gene Expression Regulation
KW - Stress, Physiological
KW - Abortion, Spontaneous/metabolism/pathology
KW - Mice, Inbred CBA
KW - Placenta/metabolism/pathology
KW - Vascular Cell Adhesion Molecule-1/biosynthesis
U2 - 10.1016/j.jri.2011.01.021
DO - 10.1016/j.jri.2011.01.021
M3 - SCORING: Journal article
VL - 89
SP - 207
EP - 211
JO - J REPROD IMMUNOL
JF - J REPROD IMMUNOL
SN - 0165-0378
IS - 2
M1 - 2
ER -