Strategies to improve the quality of survival for childhood brain tumour survivors
Standard
Strategies to improve the quality of survival for childhood brain tumour survivors. / Tallen, Gesche; Resch, Anika; Calaminus, Gabriele; Wiener, Andreas; Leiss, Ulrike; Pletschko, Thomas; Friedrich, Carsten; Langer, Thorsten; Grabow, Desiree; Driever, Pablo Hernáiz; Kortmann, Rolf-Dieter; Timmermann, Beate; Pietsch, Torsten; Warmuth-Metz, Monika; Bison, Brigitte; Thomale, Ulrich-Wilhelm; Krauss, Jürgen; Mynarek, Martin; von Hoff, Katja; Ottensmeier, Holger; Frühwald, Michael; Kramm, Christof M; Temming, Petra; Müller, Hermann L; Witt, Olaf; Kordes, Uwe; Fleischhack, Gudrun; Gnekow, Astrid; Rutkowski, Stefan; German Paediatric Brain Tumour Consortium (HIT-Network).
In: EUR J PAEDIATR NEURO, Vol. 19, No. 6, 11.2015, p. 619-39.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Strategies to improve the quality of survival for childhood brain tumour survivors
AU - Tallen, Gesche
AU - Resch, Anika
AU - Calaminus, Gabriele
AU - Wiener, Andreas
AU - Leiss, Ulrike
AU - Pletschko, Thomas
AU - Friedrich, Carsten
AU - Langer, Thorsten
AU - Grabow, Desiree
AU - Driever, Pablo Hernáiz
AU - Kortmann, Rolf-Dieter
AU - Timmermann, Beate
AU - Pietsch, Torsten
AU - Warmuth-Metz, Monika
AU - Bison, Brigitte
AU - Thomale, Ulrich-Wilhelm
AU - Krauss, Jürgen
AU - Mynarek, Martin
AU - von Hoff, Katja
AU - Ottensmeier, Holger
AU - Frühwald, Michael
AU - Kramm, Christof M
AU - Temming, Petra
AU - Müller, Hermann L
AU - Witt, Olaf
AU - Kordes, Uwe
AU - Fleischhack, Gudrun
AU - Gnekow, Astrid
AU - Rutkowski, Stefan
AU - German Paediatric Brain Tumour Consortium (HIT-Network)
N1 - Copyright © 2015 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.
PY - 2015/11
Y1 - 2015/11
N2 - BACKGROUND: Tumours of the central nervous system (CNS) are the most frequent solid tumours and the second most frequent type of cancer in children and adolescents. Overall survival has continuously improved in Germany, since an increasing number of patients have been treated according to standardised, multicentre, multimodal treatment recommendations, trials of the German Paediatric Brain Tumour Consortium (HIT-Network) or the International Society of Paediatric Oncology-Europe (SIOP-E) during the last decades. Today, two out of three patients survive. At least 8000 long-term childhood brain tumour survivors (CBTS) are currently living in Germany. They face lifelong disease- and treatment-related late effects (LE) and associated socioeconomic problems more than many other childhood cancer survivors (CCS).METHOD: We review the LE and resulting special needs of this particular group of CCS.RESULTS: Despite their increasing relevance for future treatment optimisation, neither the diversity of chronic and cumulative LE nor their pertinent risk factors and subsequent impact on quality of survival have yet been comprehensively addressed for CBTS treated according to HIT- or SIOP-E-protocols. Evidence-based information to empower survivors and stakeholders, as well as medical expertise to manage their individual health care, psychosocial and educational/vocational needs must still be generated and established.CONCLUSION: The establishment of a long-term research- and care network in Germany shall contribute to a European platform, that aims at optimising CBTSs' transition into adulthood as resilient individuals with high quality of survival including optimal levels of activity, participation and acceptance by society.
AB - BACKGROUND: Tumours of the central nervous system (CNS) are the most frequent solid tumours and the second most frequent type of cancer in children and adolescents. Overall survival has continuously improved in Germany, since an increasing number of patients have been treated according to standardised, multicentre, multimodal treatment recommendations, trials of the German Paediatric Brain Tumour Consortium (HIT-Network) or the International Society of Paediatric Oncology-Europe (SIOP-E) during the last decades. Today, two out of three patients survive. At least 8000 long-term childhood brain tumour survivors (CBTS) are currently living in Germany. They face lifelong disease- and treatment-related late effects (LE) and associated socioeconomic problems more than many other childhood cancer survivors (CCS).METHOD: We review the LE and resulting special needs of this particular group of CCS.RESULTS: Despite their increasing relevance for future treatment optimisation, neither the diversity of chronic and cumulative LE nor their pertinent risk factors and subsequent impact on quality of survival have yet been comprehensively addressed for CBTS treated according to HIT- or SIOP-E-protocols. Evidence-based information to empower survivors and stakeholders, as well as medical expertise to manage their individual health care, psychosocial and educational/vocational needs must still be generated and established.CONCLUSION: The establishment of a long-term research- and care network in Germany shall contribute to a European platform, that aims at optimising CBTSs' transition into adulthood as resilient individuals with high quality of survival including optimal levels of activity, participation and acceptance by society.
U2 - 10.1016/j.ejpn.2015.07.011
DO - 10.1016/j.ejpn.2015.07.011
M3 - SCORING: Journal article
C2 - 26278499
VL - 19
SP - 619
EP - 639
JO - EUR J PAEDIATR NEURO
JF - EUR J PAEDIATR NEURO
SN - 1090-3798
IS - 6
ER -