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Standardized visual reading of F18-FDG-PET in patients with non-small cell lung cancer scheduled for preoperative thoracic lymph node staging

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Standardized visual reading of F18-FDG-PET in patients with non-small cell lung cancer scheduled for preoperative thoracic lymph node staging. / Rogasch, Julian M M; Apostolova, Ivayla; Steffen, Ingo G; Steinkrüger, Ferdinand L G A; Genseke, Philipp; Riedel, Sandra; Wertzel, Heinz; Achenbach, H Jost; Kalinski, Thomas; Schultz, Meinald; Schreiber, Jens; Amthauer, Holger; Furth, Christian.

In: EUR J RADIOL, Vol. 85, No. 8, 08.2016, p. 1345-50.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Rogasch, JMM, Apostolova, I, Steffen, IG, Steinkrüger, FLGA, Genseke, P, Riedel, S, Wertzel, H, Achenbach, HJ, Kalinski, T, Schultz, M, Schreiber, J, Amthauer, H & Furth, C 2016, 'Standardized visual reading of F18-FDG-PET in patients with non-small cell lung cancer scheduled for preoperative thoracic lymph node staging', EUR J RADIOL, vol. 85, no. 8, pp. 1345-50. https://doi.org/10.1016/j.ejrad.2016.05.004

APA

Rogasch, J. M. M., Apostolova, I., Steffen, I. G., Steinkrüger, F. L. G. A., Genseke, P., Riedel, S., Wertzel, H., Achenbach, H. J., Kalinski, T., Schultz, M., Schreiber, J., Amthauer, H., & Furth, C. (2016). Standardized visual reading of F18-FDG-PET in patients with non-small cell lung cancer scheduled for preoperative thoracic lymph node staging. EUR J RADIOL, 85(8), 1345-50. https://doi.org/10.1016/j.ejrad.2016.05.004

Vancouver

Rogasch JMM, Apostolova I, Steffen IG, Steinkrüger FLGA, Genseke P, Riedel S et al. Standardized visual reading of F18-FDG-PET in patients with non-small cell lung cancer scheduled for preoperative thoracic lymph node staging. EUR J RADIOL. 2016 Aug;85(8):1345-50. https://doi.org/10.1016/j.ejrad.2016.05.004

Bibtex

@article{991fbc821c7045d2bc737affcc8a1d34,
title = "Standardized visual reading of F18-FDG-PET in patients with non-small cell lung cancer scheduled for preoperative thoracic lymph node staging",
abstract = "OBJECTIVES: Routine visual assessment of positron emission tomography (PET) for thoracic lymph node (LN) staging in patients with non-small cell lung cancer (NSCLC) is limited by a lack of reliable assessment criteria. This study evaluates the accuracy and inter-rater agreement of a standardized approach with unified windowing and a PET-based visual score.MATERIALS AND METHODS: This retrospective analysis included pretherapeutic FDG-PET data of 86 patients with NSCLC. After standardized windowing (threshold: 2×liver SUVmean) the LN uptake was assessed visually by three independent readers with varying levels of experience using a 4-step score (1, LN uptake≤mediastinal blood pool structures (MBPS); 2, MBPS<LNRESULTS: Fifty-four of the 278LNs (19.4%) were malignant (optimal cut-off to differentiate benign vs. malignant, score >3). The inexperienced (n=1), advanced (n=1), and expert readers (n=1) achieved similar accuracies of 93.5%, 91.4% and 92.1%, respectively (P>0.05 each). Cohen's κ ranged from 0.92 to 0.96 and Fleiss' κ was 0.93. ROC-analyses showed no significant differences between attendant readers within any subgroup (AUC, 0.92-0.96).CONCLUSION: Applying unified windowing, the introduced PET-score achieved highly accurate and robust LN assessment. This approach may shorten learning curves of inexperienced readers, facilitate multicenter trials, and improve comparability of future studies.",
keywords = "Adenocarcinoma, Adult, Aged, Aged, 80 and over, Carcinoma, Non-Small-Cell Lung, Carcinoma, Squamous Cell, Female, Fluorodeoxyglucose F18, Humans, Image Processing, Computer-Assisted, Liver, Lung Neoplasms, Lymph Nodes, Lymphatic Metastasis, Male, Mediastinum, Middle Aged, Neoplasm Grading, Neoplasm Staging, Observer Variation, Positron Emission Tomography Computed Tomography, Radiopharmaceuticals, Retrospective Studies, Sensitivity and Specificity, Journal Article",
author = "Rogasch, {Julian M M} and Ivayla Apostolova and Steffen, {Ingo G} and Steinkr{\"u}ger, {Ferdinand L G A} and Philipp Genseke and Sandra Riedel and Heinz Wertzel and Achenbach, {H Jost} and Thomas Kalinski and Meinald Schultz and Jens Schreiber and Holger Amthauer and Christian Furth",
note = "Copyright {\textcopyright} 2016 Elsevier Ireland Ltd. All rights reserved.",
year = "2016",
month = aug,
doi = "10.1016/j.ejrad.2016.05.004",
language = "English",
volume = "85",
pages = "1345--50",
journal = "EUR J RADIOL",
issn = "0720-048X",
publisher = "Elsevier",
number = "8",

}

RIS

TY - JOUR

T1 - Standardized visual reading of F18-FDG-PET in patients with non-small cell lung cancer scheduled for preoperative thoracic lymph node staging

AU - Rogasch, Julian M M

AU - Apostolova, Ivayla

AU - Steffen, Ingo G

AU - Steinkrüger, Ferdinand L G A

AU - Genseke, Philipp

AU - Riedel, Sandra

AU - Wertzel, Heinz

AU - Achenbach, H Jost

AU - Kalinski, Thomas

AU - Schultz, Meinald

AU - Schreiber, Jens

AU - Amthauer, Holger

AU - Furth, Christian

N1 - Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

PY - 2016/8

Y1 - 2016/8

N2 - OBJECTIVES: Routine visual assessment of positron emission tomography (PET) for thoracic lymph node (LN) staging in patients with non-small cell lung cancer (NSCLC) is limited by a lack of reliable assessment criteria. This study evaluates the accuracy and inter-rater agreement of a standardized approach with unified windowing and a PET-based visual score.MATERIALS AND METHODS: This retrospective analysis included pretherapeutic FDG-PET data of 86 patients with NSCLC. After standardized windowing (threshold: 2×liver SUVmean) the LN uptake was assessed visually by three independent readers with varying levels of experience using a 4-step score (1, LN uptake≤mediastinal blood pool structures (MBPS); 2, MBPS<LNRESULTS: Fifty-four of the 278LNs (19.4%) were malignant (optimal cut-off to differentiate benign vs. malignant, score >3). The inexperienced (n=1), advanced (n=1), and expert readers (n=1) achieved similar accuracies of 93.5%, 91.4% and 92.1%, respectively (P>0.05 each). Cohen's κ ranged from 0.92 to 0.96 and Fleiss' κ was 0.93. ROC-analyses showed no significant differences between attendant readers within any subgroup (AUC, 0.92-0.96).CONCLUSION: Applying unified windowing, the introduced PET-score achieved highly accurate and robust LN assessment. This approach may shorten learning curves of inexperienced readers, facilitate multicenter trials, and improve comparability of future studies.

AB - OBJECTIVES: Routine visual assessment of positron emission tomography (PET) for thoracic lymph node (LN) staging in patients with non-small cell lung cancer (NSCLC) is limited by a lack of reliable assessment criteria. This study evaluates the accuracy and inter-rater agreement of a standardized approach with unified windowing and a PET-based visual score.MATERIALS AND METHODS: This retrospective analysis included pretherapeutic FDG-PET data of 86 patients with NSCLC. After standardized windowing (threshold: 2×liver SUVmean) the LN uptake was assessed visually by three independent readers with varying levels of experience using a 4-step score (1, LN uptake≤mediastinal blood pool structures (MBPS); 2, MBPS<LNRESULTS: Fifty-four of the 278LNs (19.4%) were malignant (optimal cut-off to differentiate benign vs. malignant, score >3). The inexperienced (n=1), advanced (n=1), and expert readers (n=1) achieved similar accuracies of 93.5%, 91.4% and 92.1%, respectively (P>0.05 each). Cohen's κ ranged from 0.92 to 0.96 and Fleiss' κ was 0.93. ROC-analyses showed no significant differences between attendant readers within any subgroup (AUC, 0.92-0.96).CONCLUSION: Applying unified windowing, the introduced PET-score achieved highly accurate and robust LN assessment. This approach may shorten learning curves of inexperienced readers, facilitate multicenter trials, and improve comparability of future studies.

KW - Adenocarcinoma

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Carcinoma, Non-Small-Cell Lung

KW - Carcinoma, Squamous Cell

KW - Female

KW - Fluorodeoxyglucose F18

KW - Humans

KW - Image Processing, Computer-Assisted

KW - Liver

KW - Lung Neoplasms

KW - Lymph Nodes

KW - Lymphatic Metastasis

KW - Male

KW - Mediastinum

KW - Middle Aged

KW - Neoplasm Grading

KW - Neoplasm Staging

KW - Observer Variation

KW - Positron Emission Tomography Computed Tomography

KW - Radiopharmaceuticals

KW - Retrospective Studies

KW - Sensitivity and Specificity

KW - Journal Article

U2 - 10.1016/j.ejrad.2016.05.004

DO - 10.1016/j.ejrad.2016.05.004

M3 - SCORING: Journal article

C2 - 27423672

VL - 85

SP - 1345

EP - 1350

JO - EUR J RADIOL

JF - EUR J RADIOL

SN - 0720-048X

IS - 8

ER -