Stable Adult Hippocampal Neurogenesis in Cannabinoid Receptor CB2 Deficient Mice

Leonore Mensching; Nevena Djogo; Christina Keller; Sebastian Rading; Meliha Karsak

doi:10.3390/ijms20153759

Stable Adult Hippocampal Neurogenesis in Cannabinoid Receptor CB2 Deficient Mice

Standard

Stable Adult Hippocampal Neurogenesis in Cannabinoid Receptor CB2 Deficient Mice. / Mensching, Leonore; Djogo, Nevena; Keller, Christina; Rading, Sebastian; Karsak, Meliha.

In: INT J MOL SCI, Vol. 20, No. 15, 01.08.2019.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Mensching, L, Djogo, N, Keller, C, Rading, S & Karsak, M 2019, 'Stable Adult Hippocampal Neurogenesis in Cannabinoid Receptor CB2 Deficient Mice', INT J MOL SCI, vol. 20, no. 15. https://doi.org/10.3390/ijms20153759

APA

Mensching, L., Djogo, N., Keller, C., Rading, S., & Karsak, M. (2019). Stable Adult Hippocampal Neurogenesis in Cannabinoid Receptor CB2 Deficient Mice. INT J MOL SCI, 20(15). https://doi.org/10.3390/ijms20153759

Vancouver

Mensching L, Djogo N, Keller C, Rading S, Karsak M. Stable Adult Hippocampal Neurogenesis in Cannabinoid Receptor CB2 Deficient Mice. INT J MOL SCI. 2019 Aug 1;20(15). https://doi.org/10.3390/ijms20153759

Bibtex

@article{61dc1e96e1744bebaf687899e85ce85a,

title = "Stable Adult Hippocampal Neurogenesis in Cannabinoid Receptor CB2 Deficient Mice",

abstract = "The G-protein coupled cannabinoid receptor 2 (CB2) has been implicated in the regulation of adult neurogenesis in the hippocampus. The contribution of CB2 towards basal levels of proliferation and the number of neural progenitors in the subgranular zone (SGZ) of the dentate gyrus, however, remain unclear. We stained hippocampal brain sections of 16- to 17-week-old wildtype and CB2-deficient mice, for neural progenitor and immature neuron markers doublecortin (DCX) and calretinin (CR) and for the proliferation marker Ki67 and quantified the number of positive cells in the SGZ. The quantification revealed that CB2 deficiency neither altered overall cell proliferation nor the size of the DCX+ or DCX and CR double-positive populations in the SGZ compared to control animals. The results indicate that CB2 might not contribute to basal levels of adult neurogenesis in four-month-old healthy mice. CB2 signaling might be more relevant in conditions where adult neurogenesis is dynamically regulated, such as neuroinflammation.",

author = "Leonore Mensching and Nevena Djogo and Christina Keller and Sebastian Rading and Meliha Karsak",

year = "2019",

month = aug,

day = "1",

doi = "10.3390/ijms20153759",

language = "English",

volume = "20",

journal = "INT J MOL SCI",

issn = "1661-6596",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "15",

}

RIS

TY - JOUR

T1 - Stable Adult Hippocampal Neurogenesis in Cannabinoid Receptor CB2 Deficient Mice

AU - Mensching, Leonore

AU - Djogo, Nevena

AU - Keller, Christina

AU - Rading, Sebastian

AU - Karsak, Meliha

PY - 2019/8/1

Y1 - 2019/8/1

N2 - The G-protein coupled cannabinoid receptor 2 (CB2) has been implicated in the regulation of adult neurogenesis in the hippocampus. The contribution of CB2 towards basal levels of proliferation and the number of neural progenitors in the subgranular zone (SGZ) of the dentate gyrus, however, remain unclear. We stained hippocampal brain sections of 16- to 17-week-old wildtype and CB2-deficient mice, for neural progenitor and immature neuron markers doublecortin (DCX) and calretinin (CR) and for the proliferation marker Ki67 and quantified the number of positive cells in the SGZ. The quantification revealed that CB2 deficiency neither altered overall cell proliferation nor the size of the DCX+ or DCX and CR double-positive populations in the SGZ compared to control animals. The results indicate that CB2 might not contribute to basal levels of adult neurogenesis in four-month-old healthy mice. CB2 signaling might be more relevant in conditions where adult neurogenesis is dynamically regulated, such as neuroinflammation.

AB - The G-protein coupled cannabinoid receptor 2 (CB2) has been implicated in the regulation of adult neurogenesis in the hippocampus. The contribution of CB2 towards basal levels of proliferation and the number of neural progenitors in the subgranular zone (SGZ) of the dentate gyrus, however, remain unclear. We stained hippocampal brain sections of 16- to 17-week-old wildtype and CB2-deficient mice, for neural progenitor and immature neuron markers doublecortin (DCX) and calretinin (CR) and for the proliferation marker Ki67 and quantified the number of positive cells in the SGZ. The quantification revealed that CB2 deficiency neither altered overall cell proliferation nor the size of the DCX+ or DCX and CR double-positive populations in the SGZ compared to control animals. The results indicate that CB2 might not contribute to basal levels of adult neurogenesis in four-month-old healthy mice. CB2 signaling might be more relevant in conditions where adult neurogenesis is dynamically regulated, such as neuroinflammation.

U2 - 10.3390/ijms20153759

DO - 10.3390/ijms20153759

M3 - SCORING: Journal article

C2 - 31374821

VL - 20

JO - INT J MOL SCI

JF - INT J MOL SCI

SN - 1661-6596

IS - 15

ER -