Squamous cell carcinoma of the renal pelvis in a patient with long-term spinal cord injury-a case report

TY - JOUR

T1 - Squamous cell carcinoma of the renal pelvis in a patient with long-term spinal cord injury-a case report

AU - Balzer, Oliver

AU - Böthig, Ralf

AU - Schöps, Wolfgang

AU - Thietje, Roland

AU - Soave, Armin

AU - Kadhum, Thura

AU - Golka, Klaus

N1 - © 2021. The Author(s), under exclusive licence to International Spinal Cord Society.

PY - 2021/11/29

Y1 - 2021/11/29

N2 - INTRODUCTION: For individuals with spinal cord injury/disease (SCI/D) the risk of developing a stone in the upper urinary tract is up to six times higher than in the able-bodied population. Upper urinary tract carcinomas, in general, are rare and account for only 5-10% of all urinary tract carcinomas. It is believed that chronic upper urinary tract irritation caused by e.g., kidney stones or recurrent upper urinary tract infections may be associated with an increased risk of renal squamous cell carcinoma (RSCC).CASE PRESENTATION: We report on a 64-year-old male who suffered a spinal cord injury in 1981 resulting in a complete sensory and motor impairment below T6, AIS A. Recurrent left-sided kidney stone disease had to be treated repeatedly from 1984 onwards. Despite repeated surgical attempts, it was ultimately not possible to achieve stone clearance in the long term. Within the concept of life-long surveillance of SCI/D, the patient was examined regularly, including ultrasound examinations of the kidneys. Six months after the last control examination, the patient was admitted to our hospital with a locally advanced tumor of the left kidney, so that only the option of palliative treatment remained. Histologically an RSCC was found.DISCUSSION: As people with SCI/D have a higher risk of developing kidney stones, it is of utmost importance to check regularly for stone disease and, if necessary, treat with the aim of long-term stone clearance in order to protect renal function and to avert potentially malignant changes at an early stage.

AB - INTRODUCTION: For individuals with spinal cord injury/disease (SCI/D) the risk of developing a stone in the upper urinary tract is up to six times higher than in the able-bodied population. Upper urinary tract carcinomas, in general, are rare and account for only 5-10% of all urinary tract carcinomas. It is believed that chronic upper urinary tract irritation caused by e.g., kidney stones or recurrent upper urinary tract infections may be associated with an increased risk of renal squamous cell carcinoma (RSCC).CASE PRESENTATION: We report on a 64-year-old male who suffered a spinal cord injury in 1981 resulting in a complete sensory and motor impairment below T6, AIS A. Recurrent left-sided kidney stone disease had to be treated repeatedly from 1984 onwards. Despite repeated surgical attempts, it was ultimately not possible to achieve stone clearance in the long term. Within the concept of life-long surveillance of SCI/D, the patient was examined regularly, including ultrasound examinations of the kidneys. Six months after the last control examination, the patient was admitted to our hospital with a locally advanced tumor of the left kidney, so that only the option of palliative treatment remained. Histologically an RSCC was found.DISCUSSION: As people with SCI/D have a higher risk of developing kidney stones, it is of utmost importance to check regularly for stone disease and, if necessary, treat with the aim of long-term stone clearance in order to protect renal function and to avert potentially malignant changes at an early stage.

U2 - 10.1038/s41394-021-00466-7

DO - 10.1038/s41394-021-00466-7

M3 - SCORING: Journal article

C2 - 34845202

VL - 7

JO - SPINAL CORD SER CASE

JF - SPINAL CORD SER CASE

SN - 2058-6124

IS - 1

M1 - 102

ER -