Squamous cell carcinoma of the oral cavity and circulating tumour cells
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Squamous cell carcinoma of the oral cavity and circulating tumour cells. / Wikner, Johannes; Gröbe, Alexander; Pantel, Klaus; Riethdorf, Sabine.
In: WORLD J CLIN ONCOL, Vol. 5, No. 2, 10.05.2014, p. 114-124.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Squamous cell carcinoma of the oral cavity and circulating tumour cells
AU - Wikner, Johannes
AU - Gröbe, Alexander
AU - Pantel, Klaus
AU - Riethdorf, Sabine
N1 - Johannes Wikner, Alexander Gröbe, Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany Klaus Pantel, Sabine Riethdorf, Department of Tumor Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany
PY - 2014/5/10
Y1 - 2014/5/10
N2 - Due to a lack of substantial improvement in the outcome of patients suffering from oral squamous cell carcinoma (OSCC) during the past decades, current staging methods need to be revised. This disease is associated with poor survival rates despite considerable advances in diagnosis and treatment. The early detection of metastases is an important indicator of survival, prognosis and relapse. Therefore, a better understanding of the mechanisms underlying metastasis is crucial. Exploring alternative measures apart from common procedures is needed to identify new prognostic markers. Similar to previous findings predominantly for other solid tumours, recently published studies demonstrate that circulating tumour cells (CTCs) and disseminated tumour cells (DTCs) might serve as prognostic markers and could supplement routine staging in OSCC. Thus, the detection of CTCs/DTCs is a promising tool to determine the individual need for therapeutic intervention. Encouraging results and new approaches point to the future use of targeted therapies for OSCC, an exceedingly heterogeneous subgroup of head and neck cancer. This review focuses on summarising technologies currently used to detect CTCs/DTCs. The translational relevance for OSCC is highlighted. The inherent challenges in detecting CTCs/DTCs will be emphasised.
AB - Due to a lack of substantial improvement in the outcome of patients suffering from oral squamous cell carcinoma (OSCC) during the past decades, current staging methods need to be revised. This disease is associated with poor survival rates despite considerable advances in diagnosis and treatment. The early detection of metastases is an important indicator of survival, prognosis and relapse. Therefore, a better understanding of the mechanisms underlying metastasis is crucial. Exploring alternative measures apart from common procedures is needed to identify new prognostic markers. Similar to previous findings predominantly for other solid tumours, recently published studies demonstrate that circulating tumour cells (CTCs) and disseminated tumour cells (DTCs) might serve as prognostic markers and could supplement routine staging in OSCC. Thus, the detection of CTCs/DTCs is a promising tool to determine the individual need for therapeutic intervention. Encouraging results and new approaches point to the future use of targeted therapies for OSCC, an exceedingly heterogeneous subgroup of head and neck cancer. This review focuses on summarising technologies currently used to detect CTCs/DTCs. The translational relevance for OSCC is highlighted. The inherent challenges in detecting CTCs/DTCs will be emphasised.
KW - Journal Article
KW - Review
U2 - 10.5306/wjco.v5.i2.114
DO - 10.5306/wjco.v5.i2.114
M3 - SCORING: Review article
C2 - 24829858
VL - 5
SP - 114
EP - 124
JO - WORLD J CLIN ONCOL
JF - WORLD J CLIN ONCOL
SN - 2218-4333
IS - 2
ER -