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Spontaneous spondylodiscitis and endocarditis interdisciplinary experience from a tertiary institutional case series and proposal of a treatment algorithm

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Spontaneous spondylodiscitis and endocarditis interdisciplinary experience from a tertiary institutional case series and proposal of a treatment algorithm. / Viezens, Lennart; Dreimann, Marc; Strahl, André; Heuer, Annika; Koepke, Leon-Gordian; Bay, Benjamin; Waldeyer, Christoph; Stangenberg, Martin.

In: NEUROSURG REV, Vol. 45, No. 2, 04.2022, p. 1335-1342.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Viezens, L, Dreimann, M, Strahl, A, Heuer, A, Koepke, L-G, Bay, B, Waldeyer, C & Stangenberg, M 2022, 'Spontaneous spondylodiscitis and endocarditis interdisciplinary experience from a tertiary institutional case series and proposal of a treatment algorithm', NEUROSURG REV, vol. 45, no. 2, pp. 1335-1342. https://doi.org/10.1007/s10143-021-01640-z

APA

Viezens, L., Dreimann, M., Strahl, A., Heuer, A., Koepke, L-G., Bay, B., Waldeyer, C., & Stangenberg, M. (2022). Spontaneous spondylodiscitis and endocarditis interdisciplinary experience from a tertiary institutional case series and proposal of a treatment algorithm. NEUROSURG REV, 45(2), 1335-1342. https://doi.org/10.1007/s10143-021-01640-z

Vancouver

Viezens L, Dreimann M, Strahl A, Heuer A, Koepke L-G, Bay B et al. Spontaneous spondylodiscitis and endocarditis interdisciplinary experience from a tertiary institutional case series and proposal of a treatment algorithm. NEUROSURG REV. 2022 Apr;45(2):1335-1342. https://doi.org/10.1007/s10143-021-01640-z

Bibtex

@article{8601d68c52f440e1bbf002fe1fb97580,
title = "Spontaneous spondylodiscitis and endocarditis interdisciplinary experience from a tertiary institutional case series and proposal of a treatment algorithm",
abstract = "Previously, the simultaneous presence of endocarditis (IE) has been reported in 3-30% of spondylodiscitis cases. The specific implications on therapy and outcome of a simultaneous presence of both diseases are not yet fully evaluated. Therefore, the aim of this study was to investigate the influence of a simultaneously present endocarditis on the course of therapy and outcome of spondylodiscitis. A prospective database analysis of 328 patients diagnosed with spontaneous spondylodiscitis (S) using statistical analysis with propensity score matching was conducted. Thirty-six patients (11.0%) were diagnosed with concurrent endocarditis (SIE) by means of transoesophageal echocardiography. In our cohort, the average age was 65.82 ± 4.12 years and 64.9% of patients were male. The incidence of prior cardiac or renal disease was significantly higher in the SIE group (coronary heart disease SIE n = 13/36 vs. S n = 57/292, p < 0.05 and chronic heart failure n = 11/36 vs. S n = 41/292, p < 0.05, chronic renal failure SIE n = 14/36 vs. S n = 55/292, p < 0.05). Complex interdisciplinary coordination and diagnostics lead to a significant delay in surgical intervention (S = 4.5 ± 4.5 days vs. SIE = 8.9 ± 9.5 days, p < 0.05). Mortality did not show statistically significant differences: S (13.4%) and SIE (19.1%). Time to diagnosis and treatment is a key to efficient treatment and patient safety. In order to counteract delayed therapy, we developed a novel therapy algorithm based on the analysis of treatment processes of the SIE group. We propose a clear therapy pathway to avoid frequently observed pitfalls and delays in diagnosis to improve patient care and outcome.",
author = "Lennart Viezens and Marc Dreimann and Andr{\'e} Strahl and Annika Heuer and Leon-Gordian Koepke and Benjamin Bay and Christoph Waldeyer and Martin Stangenberg",
note = "{\textcopyright} 2021. The Author(s).",
year = "2022",
month = apr,
doi = "10.1007/s10143-021-01640-z",
language = "English",
volume = "45",
pages = "1335--1342",
journal = "NEUROSURG REV",
issn = "0344-5607",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - Spontaneous spondylodiscitis and endocarditis interdisciplinary experience from a tertiary institutional case series and proposal of a treatment algorithm

AU - Viezens, Lennart

AU - Dreimann, Marc

AU - Strahl, André

AU - Heuer, Annika

AU - Koepke, Leon-Gordian

AU - Bay, Benjamin

AU - Waldeyer, Christoph

AU - Stangenberg, Martin

N1 - © 2021. The Author(s).

PY - 2022/4

Y1 - 2022/4

N2 - Previously, the simultaneous presence of endocarditis (IE) has been reported in 3-30% of spondylodiscitis cases. The specific implications on therapy and outcome of a simultaneous presence of both diseases are not yet fully evaluated. Therefore, the aim of this study was to investigate the influence of a simultaneously present endocarditis on the course of therapy and outcome of spondylodiscitis. A prospective database analysis of 328 patients diagnosed with spontaneous spondylodiscitis (S) using statistical analysis with propensity score matching was conducted. Thirty-six patients (11.0%) were diagnosed with concurrent endocarditis (SIE) by means of transoesophageal echocardiography. In our cohort, the average age was 65.82 ± 4.12 years and 64.9% of patients were male. The incidence of prior cardiac or renal disease was significantly higher in the SIE group (coronary heart disease SIE n = 13/36 vs. S n = 57/292, p < 0.05 and chronic heart failure n = 11/36 vs. S n = 41/292, p < 0.05, chronic renal failure SIE n = 14/36 vs. S n = 55/292, p < 0.05). Complex interdisciplinary coordination and diagnostics lead to a significant delay in surgical intervention (S = 4.5 ± 4.5 days vs. SIE = 8.9 ± 9.5 days, p < 0.05). Mortality did not show statistically significant differences: S (13.4%) and SIE (19.1%). Time to diagnosis and treatment is a key to efficient treatment and patient safety. In order to counteract delayed therapy, we developed a novel therapy algorithm based on the analysis of treatment processes of the SIE group. We propose a clear therapy pathway to avoid frequently observed pitfalls and delays in diagnosis to improve patient care and outcome.

AB - Previously, the simultaneous presence of endocarditis (IE) has been reported in 3-30% of spondylodiscitis cases. The specific implications on therapy and outcome of a simultaneous presence of both diseases are not yet fully evaluated. Therefore, the aim of this study was to investigate the influence of a simultaneously present endocarditis on the course of therapy and outcome of spondylodiscitis. A prospective database analysis of 328 patients diagnosed with spontaneous spondylodiscitis (S) using statistical analysis with propensity score matching was conducted. Thirty-six patients (11.0%) were diagnosed with concurrent endocarditis (SIE) by means of transoesophageal echocardiography. In our cohort, the average age was 65.82 ± 4.12 years and 64.9% of patients were male. The incidence of prior cardiac or renal disease was significantly higher in the SIE group (coronary heart disease SIE n = 13/36 vs. S n = 57/292, p < 0.05 and chronic heart failure n = 11/36 vs. S n = 41/292, p < 0.05, chronic renal failure SIE n = 14/36 vs. S n = 55/292, p < 0.05). Complex interdisciplinary coordination and diagnostics lead to a significant delay in surgical intervention (S = 4.5 ± 4.5 days vs. SIE = 8.9 ± 9.5 days, p < 0.05). Mortality did not show statistically significant differences: S (13.4%) and SIE (19.1%). Time to diagnosis and treatment is a key to efficient treatment and patient safety. In order to counteract delayed therapy, we developed a novel therapy algorithm based on the analysis of treatment processes of the SIE group. We propose a clear therapy pathway to avoid frequently observed pitfalls and delays in diagnosis to improve patient care and outcome.

U2 - 10.1007/s10143-021-01640-z

DO - 10.1007/s10143-021-01640-z

M3 - SCORING: Journal article

C2 - 34510310

VL - 45

SP - 1335

EP - 1342

JO - NEUROSURG REV

JF - NEUROSURG REV

SN - 0344-5607

IS - 2

ER -