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Spontaneous echo contrast, left atrial appendage thrombus and stroke in patients undergoing transcatheter aortic valve implantation

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Spontaneous echo contrast, left atrial appendage thrombus and stroke in patients undergoing transcatheter aortic valve implantation. / Linder, Matthias; Voigtländer, Lisa; Schneeberger, Yvonne; Bhadra, Oliver Daniel; Grundmann, David; Demal, Till; Goßling, Alina; Ludwig, Sebastian; Schaefer, Andreas; Waldschmidt, Lara; Schirmer, Johannes; Reichenspurner, Hermann; Blankenberg, Stefan; Schäfer, Ulrich; Westermann, Dirk; Schofer, Niklas; Conradi, Lenard; Seiffert, Moritz.

In: EUROINTERVENTION, Vol. 16, No. 13, 20.01.2021, p. 1114-1122.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Linder, M, Voigtländer, L, Schneeberger, Y, Bhadra, OD, Grundmann, D, Demal, T, Goßling, A, Ludwig, S, Schaefer, A, Waldschmidt, L, Schirmer, J, Reichenspurner, H, Blankenberg, S, Schäfer, U, Westermann, D, Schofer, N, Conradi, L & Seiffert, M 2021, 'Spontaneous echo contrast, left atrial appendage thrombus and stroke in patients undergoing transcatheter aortic valve implantation', EUROINTERVENTION, vol. 16, no. 13, pp. 1114-1122. https://doi.org/10.4244/EIJ-D-20-00743

APA

Linder, M., Voigtländer, L., Schneeberger, Y., Bhadra, O. D., Grundmann, D., Demal, T., Goßling, A., Ludwig, S., Schaefer, A., Waldschmidt, L., Schirmer, J., Reichenspurner, H., Blankenberg, S., Schäfer, U., Westermann, D., Schofer, N., Conradi, L., & Seiffert, M. (2021). Spontaneous echo contrast, left atrial appendage thrombus and stroke in patients undergoing transcatheter aortic valve implantation. EUROINTERVENTION, 16(13), 1114-1122. https://doi.org/10.4244/EIJ-D-20-00743

Vancouver

Linder M, Voigtländer L, Schneeberger Y, Bhadra OD, Grundmann D, Demal T et al. Spontaneous echo contrast, left atrial appendage thrombus and stroke in patients undergoing transcatheter aortic valve implantation. EUROINTERVENTION. 2021 Jan 20;16(13):1114-1122. https://doi.org/10.4244/EIJ-D-20-00743

Bibtex

@article{5b61acb8e8984f8fa2ae2ef6a9a01993,
title = "Spontaneous echo contrast, left atrial appendage thrombus and stroke in patients undergoing transcatheter aortic valve implantation",
abstract = "AIMS: The relevance of spontaneous echo contrast (SEC) and left atrial appendage thrombus (LAAT) in patients undergoing transcatheter aortic valve implantation (TAVI) remains unclear. In this study, we aimed to assess the prevalence of SEC and LAAT and evaluate the impact on periprocedural outcome after TAVI.METHODS AND RESULTS: A total of 2,549 consecutive patients underwent TAVI between 2008 and 2017. After exclusion of cases with insufficient imaging, concomitant procedures or severe intraprocedural complications, 1,558 cases were analysed. Three groups were defined according to (pre)thrombotic formations - moderate or severe SEC (n=89), LAAT (n=53), and reference (n=1,416). The primary outcome was disabling ischaemic stroke within 24 hours. The prevalence was 4.4% for LAAT and 5.4% for moderate/severe SEC. The primary outcome occurred more frequently in patients with moderate/severe SEC (6.8%) compared to the reference (2.1%) and LAAT (1.9%) groups (p=0.020). SEC was identified as an independent risk factor for the primary outcome (OR 3.54 [95% CI: 1.30-9.61], p=0.013). LAAT was associated with an impaired unadjusted one-year survival (43.4%) compared to the SEC (27.3%) and reference groups (18.7%, p<0.001).CONCLUSIONS: SEC and LAAT were detected in a relevant number of patients undergoing TAVI. SEC may represent an important risk factor for intraprocedural stroke; increased mortality was observed in patients with LAAT.",
author = "Matthias Linder and Lisa Voigtl{\"a}nder and Yvonne Schneeberger and Bhadra, {Oliver Daniel} and David Grundmann and Till Demal and Alina Go{\ss}ling and Sebastian Ludwig and Andreas Schaefer and Lara Waldschmidt and Johannes Schirmer and Hermann Reichenspurner and Stefan Blankenberg and Ulrich Sch{\"a}fer and Dirk Westermann and Niklas Schofer and Lenard Conradi and Moritz Seiffert",
year = "2021",
month = jan,
day = "20",
doi = "10.4244/EIJ-D-20-00743",
language = "English",
volume = "16",
pages = "1114--1122",
journal = "EUROINTERVENTION",
issn = "1774-024X",
publisher = "EUROPA EDITION",
number = "13",

}

RIS

TY - JOUR

T1 - Spontaneous echo contrast, left atrial appendage thrombus and stroke in patients undergoing transcatheter aortic valve implantation

AU - Linder, Matthias

AU - Voigtländer, Lisa

AU - Schneeberger, Yvonne

AU - Bhadra, Oliver Daniel

AU - Grundmann, David

AU - Demal, Till

AU - Goßling, Alina

AU - Ludwig, Sebastian

AU - Schaefer, Andreas

AU - Waldschmidt, Lara

AU - Schirmer, Johannes

AU - Reichenspurner, Hermann

AU - Blankenberg, Stefan

AU - Schäfer, Ulrich

AU - Westermann, Dirk

AU - Schofer, Niklas

AU - Conradi, Lenard

AU - Seiffert, Moritz

PY - 2021/1/20

Y1 - 2021/1/20

N2 - AIMS: The relevance of spontaneous echo contrast (SEC) and left atrial appendage thrombus (LAAT) in patients undergoing transcatheter aortic valve implantation (TAVI) remains unclear. In this study, we aimed to assess the prevalence of SEC and LAAT and evaluate the impact on periprocedural outcome after TAVI.METHODS AND RESULTS: A total of 2,549 consecutive patients underwent TAVI between 2008 and 2017. After exclusion of cases with insufficient imaging, concomitant procedures or severe intraprocedural complications, 1,558 cases were analysed. Three groups were defined according to (pre)thrombotic formations - moderate or severe SEC (n=89), LAAT (n=53), and reference (n=1,416). The primary outcome was disabling ischaemic stroke within 24 hours. The prevalence was 4.4% for LAAT and 5.4% for moderate/severe SEC. The primary outcome occurred more frequently in patients with moderate/severe SEC (6.8%) compared to the reference (2.1%) and LAAT (1.9%) groups (p=0.020). SEC was identified as an independent risk factor for the primary outcome (OR 3.54 [95% CI: 1.30-9.61], p=0.013). LAAT was associated with an impaired unadjusted one-year survival (43.4%) compared to the SEC (27.3%) and reference groups (18.7%, p<0.001).CONCLUSIONS: SEC and LAAT were detected in a relevant number of patients undergoing TAVI. SEC may represent an important risk factor for intraprocedural stroke; increased mortality was observed in patients with LAAT.

AB - AIMS: The relevance of spontaneous echo contrast (SEC) and left atrial appendage thrombus (LAAT) in patients undergoing transcatheter aortic valve implantation (TAVI) remains unclear. In this study, we aimed to assess the prevalence of SEC and LAAT and evaluate the impact on periprocedural outcome after TAVI.METHODS AND RESULTS: A total of 2,549 consecutive patients underwent TAVI between 2008 and 2017. After exclusion of cases with insufficient imaging, concomitant procedures or severe intraprocedural complications, 1,558 cases were analysed. Three groups were defined according to (pre)thrombotic formations - moderate or severe SEC (n=89), LAAT (n=53), and reference (n=1,416). The primary outcome was disabling ischaemic stroke within 24 hours. The prevalence was 4.4% for LAAT and 5.4% for moderate/severe SEC. The primary outcome occurred more frequently in patients with moderate/severe SEC (6.8%) compared to the reference (2.1%) and LAAT (1.9%) groups (p=0.020). SEC was identified as an independent risk factor for the primary outcome (OR 3.54 [95% CI: 1.30-9.61], p=0.013). LAAT was associated with an impaired unadjusted one-year survival (43.4%) compared to the SEC (27.3%) and reference groups (18.7%, p<0.001).CONCLUSIONS: SEC and LAAT were detected in a relevant number of patients undergoing TAVI. SEC may represent an important risk factor for intraprocedural stroke; increased mortality was observed in patients with LAAT.

U2 - 10.4244/EIJ-D-20-00743

DO - 10.4244/EIJ-D-20-00743

M3 - SCORING: Journal article

C2 - 32863242

VL - 16

SP - 1114

EP - 1122

JO - EUROINTERVENTION

JF - EUROINTERVENTION

SN - 1774-024X

IS - 13

ER -