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Spike-timing-dependent plasticity rewards synchrony rather than causality

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Spike-timing-dependent plasticity rewards synchrony rather than causality. / Anisimova, Margarita; van Bommel, Bas; Wang, Rui; Mikhaylova, Marina; Wiegert, J. Simon; Oertner, Thomas G; Gee, Christine E.

In: CEREB CORTEX, Vol. 33, No. 1, bhac050, 15.12.2022, p. 23-34.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Anisimova, M, van Bommel, B, Wang, R, Mikhaylova, M, Wiegert, JS, Oertner, TG & Gee, CE 2022, 'Spike-timing-dependent plasticity rewards synchrony rather than causality', CEREB CORTEX, vol. 33, no. 1, bhac050, pp. 23-34. https://doi.org/10.1093/cercor/bhac050

APA

Anisimova, M., van Bommel, B., Wang, R., Mikhaylova, M., Wiegert, J. S., Oertner, T. G., & Gee, C. E. (2022). Spike-timing-dependent plasticity rewards synchrony rather than causality. CEREB CORTEX, 33(1), 23-34. [bhac050]. https://doi.org/10.1093/cercor/bhac050

Vancouver

Anisimova M, van Bommel B, Wang R, Mikhaylova M, Wiegert JS, Oertner TG et al. Spike-timing-dependent plasticity rewards synchrony rather than causality. CEREB CORTEX. 2022 Dec 15;33(1):23-34. bhac050. https://doi.org/10.1093/cercor/bhac050

Bibtex

@article{bf03fef78c1c4a6a84c913d32660c472,
title = "Spike-timing-dependent plasticity rewards synchrony rather than causality",
abstract = "Spike-timing-dependent plasticity (STDP) is a candidate mechanism for information storage in the brain, but the whole-cell recordings required for the experimental induction of STDP are typically limited to 1 h. This mismatch of time scales is a long-standing weakness in synaptic theories of memory. Here we use spectrally separated optogenetic stimulation to fire precisely timed action potentials (spikes) in CA3 and CA1 pyramidal cells. Twenty minutes after optogenetic induction of STDP (oSTDP), we observed timing-dependent depression (tLTD) and timing-dependent potentiation (tLTP), depending on the sequence of spiking. As oSTDP does not require electrodes, we could also assess the strength of these paired connections three days later. At this late time point, late tLTP was observed for both causal (CA3 before CA1) and anticausal (CA1 before CA3) timing, but not for asynchronous activity patterns (Δt = 50 ms). Blocking activity after induction of oSTDP prevented stable potentiation. Our results confirm that neurons wire together if they fire together, but suggest that synaptic depression after anticausal activation (tLTD) is a transient phenomenon.",
author = "Margarita Anisimova and {van Bommel}, Bas and Rui Wang and Marina Mikhaylova and Wiegert, {J. Simon} and Oertner, {Thomas G} and Gee, {Christine E}",
note = "{\textcopyright} The Author(s) 2022. Published by Oxford University Press.",
year = "2022",
month = dec,
day = "15",
doi = "10.1093/cercor/bhac050",
language = "English",
volume = "33",
pages = "23--34",
journal = "CEREB CORTEX",
issn = "1047-3211",
publisher = "Oxford University Press",
number = "1",

}

RIS

TY - JOUR

T1 - Spike-timing-dependent plasticity rewards synchrony rather than causality

AU - Anisimova, Margarita

AU - van Bommel, Bas

AU - Wang, Rui

AU - Mikhaylova, Marina

AU - Wiegert, J. Simon

AU - Oertner, Thomas G

AU - Gee, Christine E

N1 - © The Author(s) 2022. Published by Oxford University Press.

PY - 2022/12/15

Y1 - 2022/12/15

N2 - Spike-timing-dependent plasticity (STDP) is a candidate mechanism for information storage in the brain, but the whole-cell recordings required for the experimental induction of STDP are typically limited to 1 h. This mismatch of time scales is a long-standing weakness in synaptic theories of memory. Here we use spectrally separated optogenetic stimulation to fire precisely timed action potentials (spikes) in CA3 and CA1 pyramidal cells. Twenty minutes after optogenetic induction of STDP (oSTDP), we observed timing-dependent depression (tLTD) and timing-dependent potentiation (tLTP), depending on the sequence of spiking. As oSTDP does not require electrodes, we could also assess the strength of these paired connections three days later. At this late time point, late tLTP was observed for both causal (CA3 before CA1) and anticausal (CA1 before CA3) timing, but not for asynchronous activity patterns (Δt = 50 ms). Blocking activity after induction of oSTDP prevented stable potentiation. Our results confirm that neurons wire together if they fire together, but suggest that synaptic depression after anticausal activation (tLTD) is a transient phenomenon.

AB - Spike-timing-dependent plasticity (STDP) is a candidate mechanism for information storage in the brain, but the whole-cell recordings required for the experimental induction of STDP are typically limited to 1 h. This mismatch of time scales is a long-standing weakness in synaptic theories of memory. Here we use spectrally separated optogenetic stimulation to fire precisely timed action potentials (spikes) in CA3 and CA1 pyramidal cells. Twenty minutes after optogenetic induction of STDP (oSTDP), we observed timing-dependent depression (tLTD) and timing-dependent potentiation (tLTP), depending on the sequence of spiking. As oSTDP does not require electrodes, we could also assess the strength of these paired connections three days later. At this late time point, late tLTP was observed for both causal (CA3 before CA1) and anticausal (CA1 before CA3) timing, but not for asynchronous activity patterns (Δt = 50 ms). Blocking activity after induction of oSTDP prevented stable potentiation. Our results confirm that neurons wire together if they fire together, but suggest that synaptic depression after anticausal activation (tLTD) is a transient phenomenon.

U2 - 10.1093/cercor/bhac050

DO - 10.1093/cercor/bhac050

M3 - SCORING: Journal article

C2 - 35203089

VL - 33

SP - 23

EP - 34

JO - CEREB CORTEX

JF - CEREB CORTEX

SN - 1047-3211

IS - 1

M1 - bhac050

ER -