Sphingosine-1-Phosphate-Receptor 1 as a Marker for Endothelial Cells in Mouse Xenograft Models of Human Cancer

Nadine Lüders; Udo Schumacher

Sphingosine-1-Phosphate-Receptor 1 as a Marker for Endothelial Cells in Mouse Xenograft Models of Human Cancer

Standard

Sphingosine-1-Phosphate-Receptor 1 as a Marker for Endothelial Cells in Mouse Xenograft Models of Human Cancer. / Lüders, Nadine; Schumacher, Udo.

In: ANTICANCER RES, Vol. 37, No. 7, 07.2017, p. 3607-3614.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Lüders, N & Schumacher, U 2017, 'Sphingosine-1-Phosphate-Receptor 1 as a Marker for Endothelial Cells in Mouse Xenograft Models of Human Cancer', ANTICANCER RES, vol. 37, no. 7, pp. 3607-3614.

APA

Lüders, N., & Schumacher, U. (2017). Sphingosine-1-Phosphate-Receptor 1 as a Marker for Endothelial Cells in Mouse Xenograft Models of Human Cancer. ANTICANCER RES, 37(7), 3607-3614.

Vancouver

Lüders N, Schumacher U. Sphingosine-1-Phosphate-Receptor 1 as a Marker for Endothelial Cells in Mouse Xenograft Models of Human Cancer. ANTICANCER RES. 2017 Jul;37(7):3607-3614.

Bibtex

@article{3a8d6d3089874f2fb2aef49e47d0f2d2,

title = "Sphingosine-1-Phosphate-Receptor 1 as a Marker for Endothelial Cells in Mouse Xenograft Models of Human Cancer",

abstract = "BACKGROUND/AIM: The sphingosine-1-phosphate (S1P) 1 receptor (S1P1R) is an important receptor for the modulation of endothelial cell function. We, therefore, wanted to investigate its expression as a blood vessel marker.MATERIALS AND METHODS: The expression of the S1P receptor 1 (S1P1R) in mouse blood vessel endothelium was investigated immunohistochemically in normal blood vessel endothelium and blood vessel endothelium of xenografted human tumors.RESULTS: The S1P1 receptor was expressed in the endothelium of most mouse organs. Endothelia of the intestinal tract and of adipose tissue showed the strongest immunoreactivity. However, a difference in staining between larger vessels and fenestrated endothelium was observed, whereas fenestrated endothelium expressed a weaker staining. In addition to normal endothelia, most tumor blood vessel endothelia expressed S1P1R. A particularly strong expression in the endothelium was detected in primary pancreatic and prostate cancer xenografts. In both xenograft tumor entities, no significant difference in staining intensities of the endothelium between arteries, veins and capillaries was observed.CONCLUSION: As S1P1R is expressed in most blood vessel endothelia and in the tumor blood vessel endothelia, it is an ideal blood vessel marker.",

keywords = "Journal Article",

author = "Nadine L{\"u}ders and Udo Schumacher",

year = "2017",

month = jul,

language = "English",

volume = "37",

pages = "3607--3614",

journal = "ANTICANCER RES",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "7",

}

RIS

TY - JOUR

T1 - Sphingosine-1-Phosphate-Receptor 1 as a Marker for Endothelial Cells in Mouse Xenograft Models of Human Cancer

AU - Lüders, Nadine

AU - Schumacher, Udo

PY - 2017/7

Y1 - 2017/7

N2 - BACKGROUND/AIM: The sphingosine-1-phosphate (S1P) 1 receptor (S1P1R) is an important receptor for the modulation of endothelial cell function. We, therefore, wanted to investigate its expression as a blood vessel marker.MATERIALS AND METHODS: The expression of the S1P receptor 1 (S1P1R) in mouse blood vessel endothelium was investigated immunohistochemically in normal blood vessel endothelium and blood vessel endothelium of xenografted human tumors.RESULTS: The S1P1 receptor was expressed in the endothelium of most mouse organs. Endothelia of the intestinal tract and of adipose tissue showed the strongest immunoreactivity. However, a difference in staining between larger vessels and fenestrated endothelium was observed, whereas fenestrated endothelium expressed a weaker staining. In addition to normal endothelia, most tumor blood vessel endothelia expressed S1P1R. A particularly strong expression in the endothelium was detected in primary pancreatic and prostate cancer xenografts. In both xenograft tumor entities, no significant difference in staining intensities of the endothelium between arteries, veins and capillaries was observed.CONCLUSION: As S1P1R is expressed in most blood vessel endothelia and in the tumor blood vessel endothelia, it is an ideal blood vessel marker.

AB - BACKGROUND/AIM: The sphingosine-1-phosphate (S1P) 1 receptor (S1P1R) is an important receptor for the modulation of endothelial cell function. We, therefore, wanted to investigate its expression as a blood vessel marker.MATERIALS AND METHODS: The expression of the S1P receptor 1 (S1P1R) in mouse blood vessel endothelium was investigated immunohistochemically in normal blood vessel endothelium and blood vessel endothelium of xenografted human tumors.RESULTS: The S1P1 receptor was expressed in the endothelium of most mouse organs. Endothelia of the intestinal tract and of adipose tissue showed the strongest immunoreactivity. However, a difference in staining between larger vessels and fenestrated endothelium was observed, whereas fenestrated endothelium expressed a weaker staining. In addition to normal endothelia, most tumor blood vessel endothelia expressed S1P1R. A particularly strong expression in the endothelium was detected in primary pancreatic and prostate cancer xenografts. In both xenograft tumor entities, no significant difference in staining intensities of the endothelium between arteries, veins and capillaries was observed.CONCLUSION: As S1P1R is expressed in most blood vessel endothelia and in the tumor blood vessel endothelia, it is an ideal blood vessel marker.

KW - Journal Article

M3 - SCORING: Journal article

C2 - 28668852

VL - 37

SP - 3607

EP - 3614

JO - ANTICANCER RES

JF - ANTICANCER RES

SN - 0250-7005

IS - 7

ER -