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Spectral cardiac CT in acute stroke patients

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Spectral cardiac CT in acute stroke patients. / Larsen, Naomi; Austein, Friederike; Klintz, Tristan; Campbell, Graeme; Sedaghat, Sam; Aludin, Schekeb; Schunk, Domagoj; Both, Marcus; Jansen, Olav; Langguth, Patrick.

In: SCI REP-UK, Vol. 13, No. 1, 6781, 25.04.2023.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Larsen, N, Austein, F, Klintz, T, Campbell, G, Sedaghat, S, Aludin, S, Schunk, D, Both, M, Jansen, O & Langguth, P 2023, 'Spectral cardiac CT in acute stroke patients', SCI REP-UK, vol. 13, no. 1, 6781. https://doi.org/10.1038/s41598-023-33940-3

APA

Larsen, N., Austein, F., Klintz, T., Campbell, G., Sedaghat, S., Aludin, S., Schunk, D., Both, M., Jansen, O., & Langguth, P. (2023). Spectral cardiac CT in acute stroke patients. SCI REP-UK, 13(1), [6781]. https://doi.org/10.1038/s41598-023-33940-3

Vancouver

Larsen N, Austein F, Klintz T, Campbell G, Sedaghat S, Aludin S et al. Spectral cardiac CT in acute stroke patients. SCI REP-UK. 2023 Apr 25;13(1). 6781. https://doi.org/10.1038/s41598-023-33940-3

Bibtex

@article{36432f5483364043bbba5cb2c3bb952a,
title = "Spectral cardiac CT in acute stroke patients",
abstract = "Cardiac CT obtained in acute ischemic stroke patients can facilitate timely detection of cardiac sources of embolism and guide secondary prevention strategies. Spectral CT exploiting the simultaneous acquisition of separate higher-energy and lower-energy photon spectrum datasets has the potential to improve contrast between thrombi and cardiac structures. This study aimed to investigate the diagnostic value of spectral cardiac CT compared to conventional CT for the detection of cardiac thrombi in acute stroke patients. Patients with acute ischemic stroke undergoing spectral cardiac CT were retrospectively included. Conventional CT images, virtual 55 keV monoenergetic (monoE55), z-effective (zeff), and iodine density images were evaluated for the presence of thrombi. Diagnostic certainty was rated on a 5-point Likert scale. Contrast ratios were calculated for all reconstructions. 63 patients with 20 thrombi were included. Four thrombi were missed on conventional images but detected on spectral reconstructions. MonoE55 achieved the highest scores for diagnostic certainty. Contrast ratios were highest on iodine density images, followed by monoE55, conventional and zeff (p < 0.005). Spectral cardiac CT adds diagnostic benefit for the detection of intra-cardiac thrombi in acute ischemic stroke patients compared to conventional CT.",
keywords = "Humans, Ischemic Stroke, Retrospective Studies, Signal-To-Noise Ratio, Tomography, X-Ray Computed/methods, Iodine, Stroke/diagnostic imaging, Radiographic Image Interpretation, Computer-Assisted/methods",
author = "Naomi Larsen and Friederike Austein and Tristan Klintz and Graeme Campbell and Sam Sedaghat and Schekeb Aludin and Domagoj Schunk and Marcus Both and Olav Jansen and Patrick Langguth",
note = "{\textcopyright} 2023. The Author(s).",
year = "2023",
month = apr,
day = "25",
doi = "10.1038/s41598-023-33940-3",
language = "English",
volume = "13",
journal = "SCI REP-UK",
issn = "2045-2322",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Spectral cardiac CT in acute stroke patients

AU - Larsen, Naomi

AU - Austein, Friederike

AU - Klintz, Tristan

AU - Campbell, Graeme

AU - Sedaghat, Sam

AU - Aludin, Schekeb

AU - Schunk, Domagoj

AU - Both, Marcus

AU - Jansen, Olav

AU - Langguth, Patrick

N1 - © 2023. The Author(s).

PY - 2023/4/25

Y1 - 2023/4/25

N2 - Cardiac CT obtained in acute ischemic stroke patients can facilitate timely detection of cardiac sources of embolism and guide secondary prevention strategies. Spectral CT exploiting the simultaneous acquisition of separate higher-energy and lower-energy photon spectrum datasets has the potential to improve contrast between thrombi and cardiac structures. This study aimed to investigate the diagnostic value of spectral cardiac CT compared to conventional CT for the detection of cardiac thrombi in acute stroke patients. Patients with acute ischemic stroke undergoing spectral cardiac CT were retrospectively included. Conventional CT images, virtual 55 keV monoenergetic (monoE55), z-effective (zeff), and iodine density images were evaluated for the presence of thrombi. Diagnostic certainty was rated on a 5-point Likert scale. Contrast ratios were calculated for all reconstructions. 63 patients with 20 thrombi were included. Four thrombi were missed on conventional images but detected on spectral reconstructions. MonoE55 achieved the highest scores for diagnostic certainty. Contrast ratios were highest on iodine density images, followed by monoE55, conventional and zeff (p < 0.005). Spectral cardiac CT adds diagnostic benefit for the detection of intra-cardiac thrombi in acute ischemic stroke patients compared to conventional CT.

AB - Cardiac CT obtained in acute ischemic stroke patients can facilitate timely detection of cardiac sources of embolism and guide secondary prevention strategies. Spectral CT exploiting the simultaneous acquisition of separate higher-energy and lower-energy photon spectrum datasets has the potential to improve contrast between thrombi and cardiac structures. This study aimed to investigate the diagnostic value of spectral cardiac CT compared to conventional CT for the detection of cardiac thrombi in acute stroke patients. Patients with acute ischemic stroke undergoing spectral cardiac CT were retrospectively included. Conventional CT images, virtual 55 keV monoenergetic (monoE55), z-effective (zeff), and iodine density images were evaluated for the presence of thrombi. Diagnostic certainty was rated on a 5-point Likert scale. Contrast ratios were calculated for all reconstructions. 63 patients with 20 thrombi were included. Four thrombi were missed on conventional images but detected on spectral reconstructions. MonoE55 achieved the highest scores for diagnostic certainty. Contrast ratios were highest on iodine density images, followed by monoE55, conventional and zeff (p < 0.005). Spectral cardiac CT adds diagnostic benefit for the detection of intra-cardiac thrombi in acute ischemic stroke patients compared to conventional CT.

KW - Humans

KW - Ischemic Stroke

KW - Retrospective Studies

KW - Signal-To-Noise Ratio

KW - Tomography, X-Ray Computed/methods

KW - Iodine

KW - Stroke/diagnostic imaging

KW - Radiographic Image Interpretation, Computer-Assisted/methods

U2 - 10.1038/s41598-023-33940-3

DO - 10.1038/s41598-023-33940-3

M3 - SCORING: Journal article

C2 - 37185943

VL - 13

JO - SCI REP-UK

JF - SCI REP-UK

SN - 2045-2322

IS - 1

M1 - 6781

ER -