Specific neurotoxicity of chronic use of ecstasy.
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Specific neurotoxicity of chronic use of ecstasy. / Obrocki, J; Schmoldt, A; Buchert, Ralph; Andresen, B; Petersen, K; Thomasius, R.
In: TOXICOL LETT, Vol. 127, No. 1-3, 1-3, 2002, p. 285-297.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Specific neurotoxicity of chronic use of ecstasy.
AU - Obrocki, J
AU - Schmoldt, A
AU - Buchert, Ralph
AU - Andresen, B
AU - Petersen, K
AU - Thomasius, R
PY - 2002
Y1 - 2002
N2 - The use of the illicit drug ecstasy (mainly containing methylenedioxymethamphetamine, MDMA) is widespread among young people in western Nations. Animal experiments indicate that MDMA is a potent neurotoxin specifically affecting the serotonergic system. A few functional neuroimaging studies revealed central nervous alterations after the repeated use of ecstasy. We examined 94 ecstasy users in comparison to 27 control subjects by means of positron emission tomography (PET) with 2-[18F]-fluoro-2-deoxy-D-glucose (FDG). The FDG uptake rates were globally reduced in ecstasy users, most pronounced in the striatum. The uptake rates tended to be negatively correlated with the cumulative ecstasy doses. The results indicate that younger ecstasy users may be more vulnerable with regard to neurotoxicity.
AB - The use of the illicit drug ecstasy (mainly containing methylenedioxymethamphetamine, MDMA) is widespread among young people in western Nations. Animal experiments indicate that MDMA is a potent neurotoxin specifically affecting the serotonergic system. A few functional neuroimaging studies revealed central nervous alterations after the repeated use of ecstasy. We examined 94 ecstasy users in comparison to 27 control subjects by means of positron emission tomography (PET) with 2-[18F]-fluoro-2-deoxy-D-glucose (FDG). The FDG uptake rates were globally reduced in ecstasy users, most pronounced in the striatum. The uptake rates tended to be negatively correlated with the cumulative ecstasy doses. The results indicate that younger ecstasy users may be more vulnerable with regard to neurotoxicity.
M3 - SCORING: Zeitschriftenaufsatz
VL - 127
SP - 285
EP - 297
JO - TOXICOL LETT
JF - TOXICOL LETT
SN - 0378-4274
IS - 1-3
M1 - 1-3
ER -
