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Specific localization of Rabs at intracellular membranes

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Specific localization of Rabs at intracellular membranes. / Blümer, Julia; Wu, Yao-Wen; Goody, Roger S; Itzen, Aymelt.

In: BIOCHEM SOC T, Vol. 40, No. 6, 01.12.2012, p. 1421-5.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Blümer, J, Wu, Y-W, Goody, RS & Itzen, A 2012, 'Specific localization of Rabs at intracellular membranes', BIOCHEM SOC T, vol. 40, no. 6, pp. 1421-5. https://doi.org/10.1042/BST20120225

APA

Blümer, J., Wu, Y-W., Goody, R. S., & Itzen, A. (2012). Specific localization of Rabs at intracellular membranes. BIOCHEM SOC T, 40(6), 1421-5. https://doi.org/10.1042/BST20120225

Vancouver

Blümer J, Wu Y-W, Goody RS, Itzen A. Specific localization of Rabs at intracellular membranes. BIOCHEM SOC T. 2012 Dec 1;40(6):1421-5. https://doi.org/10.1042/BST20120225

Bibtex

@article{47ad778fcd1645faa7a7249dcc2c29db,
title = "Specific localization of Rabs at intracellular membranes",
abstract = "Despite over two decades of research, the mechanism of Rab targeting to specific intracellular membranes is still not completely understood. Present evidence suggests that the original hypothesis that the message for targeting resides solely in the hypervariable C-terminus is incorrect, and a second mechanism involving a GDF [GDI (guanine-nucleotide-dissociation inhibitor) displacement factor] to disrupt stable Rab-GDI complexes has only been shown to apply in one case, despite the need for targeting over 60 human Rab proteins. Evidence for the involvement of Rab-effector interactions has only been presented for a few cases or in a very specific context. There is mounting evidence that GEFs (guanine-nucleotide-exchange factors) are essential for membrane targeting, although contributions from additional factors are likely to be of importance, at least in specific cases.",
keywords = "Guanine Nucleotide Dissociation Inhibitors, Guanine Nucleotide Exchange Factors, Humans, Intracellular Membranes, Models, Biological, Protein Sorting Signals, Protein Transport, rab GTP-Binding Proteins, Journal Article",
author = "Julia Bl{\"u}mer and Yao-Wen Wu and Goody, {Roger S} and Aymelt Itzen",
year = "2012",
month = dec,
day = "1",
doi = "10.1042/BST20120225",
language = "English",
volume = "40",
pages = "1421--5",
journal = "BIOCHEM SOC T",
issn = "0300-5127",
publisher = "PORTLAND PRESS LTD",
number = "6",

}

RIS

TY - JOUR

T1 - Specific localization of Rabs at intracellular membranes

AU - Blümer, Julia

AU - Wu, Yao-Wen

AU - Goody, Roger S

AU - Itzen, Aymelt

PY - 2012/12/1

Y1 - 2012/12/1

N2 - Despite over two decades of research, the mechanism of Rab targeting to specific intracellular membranes is still not completely understood. Present evidence suggests that the original hypothesis that the message for targeting resides solely in the hypervariable C-terminus is incorrect, and a second mechanism involving a GDF [GDI (guanine-nucleotide-dissociation inhibitor) displacement factor] to disrupt stable Rab-GDI complexes has only been shown to apply in one case, despite the need for targeting over 60 human Rab proteins. Evidence for the involvement of Rab-effector interactions has only been presented for a few cases or in a very specific context. There is mounting evidence that GEFs (guanine-nucleotide-exchange factors) are essential for membrane targeting, although contributions from additional factors are likely to be of importance, at least in specific cases.

AB - Despite over two decades of research, the mechanism of Rab targeting to specific intracellular membranes is still not completely understood. Present evidence suggests that the original hypothesis that the message for targeting resides solely in the hypervariable C-terminus is incorrect, and a second mechanism involving a GDF [GDI (guanine-nucleotide-dissociation inhibitor) displacement factor] to disrupt stable Rab-GDI complexes has only been shown to apply in one case, despite the need for targeting over 60 human Rab proteins. Evidence for the involvement of Rab-effector interactions has only been presented for a few cases or in a very specific context. There is mounting evidence that GEFs (guanine-nucleotide-exchange factors) are essential for membrane targeting, although contributions from additional factors are likely to be of importance, at least in specific cases.

KW - Guanine Nucleotide Dissociation Inhibitors

KW - Guanine Nucleotide Exchange Factors

KW - Humans

KW - Intracellular Membranes

KW - Models, Biological

KW - Protein Sorting Signals

KW - Protein Transport

KW - rab GTP-Binding Proteins

KW - Journal Article

U2 - 10.1042/BST20120225

DO - 10.1042/BST20120225

M3 - SCORING: Journal article

C2 - 23176492

VL - 40

SP - 1421

EP - 1425

JO - BIOCHEM SOC T

JF - BIOCHEM SOC T

SN - 0300-5127

IS - 6

ER -