Specialized structure of neural population codes in parietal cortex outputs
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Specialized structure of neural population codes in parietal cortex outputs. / Safaai, Houman; Wang, Alice Y; Kira, Shinichiro; Malerba, Simone Blanco; Panzeri, Stefano; Harvey, Christopher D.
In: bioRxiv, 26.08.2023.Research output: SCORING: Contribution to journal › Preprint › Research
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TY - JOUR
T1 - Specialized structure of neural population codes in parietal cortex outputs
AU - Safaai, Houman
AU - Wang, Alice Y
AU - Kira, Shinichiro
AU - Malerba, Simone Blanco
AU - Panzeri, Stefano
AU - Harvey, Christopher D
PY - 2023/8/26
Y1 - 2023/8/26
N2 - Do cortical neurons that send axonal projections to the same target area form specialized population codes for transmitting information? We used calcium imaging in mouse posterior parietal cortex (PPC), retrograde labeling, and statistical multivariate models to address this question during a delayed match-to-sample task. We found that PPC broadcasts sensory, choice, and locomotion signals widely, but sensory information is enriched in the output to anterior cingulate cortex. Neurons projecting to the same area have elevated pairwise activity correlations. These correlations are structured as information-limiting and information-enhancing interaction networks that collectively enhance information levels. This network structure is unique to sub-populations projecting to the same target and strikingly absent in surrounding neural populations with unidentified projections. Furthermore, this structure is only present when mice make correct, but not incorrect, behavioral choices. Therefore, cortical neurons comprising an output pathway form uniquely structured population codes that enhance information transmission to guide accurate behavior.
AB - Do cortical neurons that send axonal projections to the same target area form specialized population codes for transmitting information? We used calcium imaging in mouse posterior parietal cortex (PPC), retrograde labeling, and statistical multivariate models to address this question during a delayed match-to-sample task. We found that PPC broadcasts sensory, choice, and locomotion signals widely, but sensory information is enriched in the output to anterior cingulate cortex. Neurons projecting to the same area have elevated pairwise activity correlations. These correlations are structured as information-limiting and information-enhancing interaction networks that collectively enhance information levels. This network structure is unique to sub-populations projecting to the same target and strikingly absent in surrounding neural populations with unidentified projections. Furthermore, this structure is only present when mice make correct, but not incorrect, behavioral choices. Therefore, cortical neurons comprising an output pathway form uniquely structured population codes that enhance information transmission to guide accurate behavior.
U2 - 10.1101/2023.08.24.554635
DO - 10.1101/2023.08.24.554635
M3 - Preprint
C2 - 37662297
JO - bioRxiv
JF - bioRxiv
SN - 2692-8205
ER -