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Spatial memory tasks in rodents: what do they model?

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Spatial memory tasks in rodents: what do they model? / Morellini, Fabio.

In: CELL TISSUE RES, Vol. 354, No. 1, 01.10.2013, p. 273-86.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Morellini, F 2013, 'Spatial memory tasks in rodents: what do they model?', CELL TISSUE RES, vol. 354, no. 1, pp. 273-86. https://doi.org/10.1007/s00441-013-1668-9

APA

Morellini, F. (2013). Spatial memory tasks in rodents: what do they model? CELL TISSUE RES, 354(1), 273-86. https://doi.org/10.1007/s00441-013-1668-9

Vancouver

Morellini F. Spatial memory tasks in rodents: what do they model? CELL TISSUE RES. 2013 Oct 1;354(1):273-86. https://doi.org/10.1007/s00441-013-1668-9

Bibtex

@article{b6830b1cfff9406da0379091f1734e80,
title = "Spatial memory tasks in rodents: what do they model?",
abstract = "The analysis of spatial learning and memory in rodents is commonly used to investigate the mechanisms underlying certain forms of human cognition and to model their dysfunction in neuropsychiatric and neurodegenerative diseases. Proper interpretation of rodent behavior in terms of spatial memory and as a model of human cognitive functions is only possible if various navigation strategies and factors controlling the performance of the animal in a spatial task are taken into consideration. The aim of this review is to describe the experimental approaches that are being used for the study of spatial memory in rats and mice and the way that they can be interpreted in terms of general memory functions. After an introduction to the classification of memory into various categories and respective underlying neuroanatomical substrates, I explain the concept of spatial memory and its measurement in rats and mice by analysis of their navigation strategies. Subsequently, I describe the most common paradigms for spatial memory assessment with specific focus on methodological issues relevant for the correct interpretation of the results in terms of cognitive function. Finally, I present recent advances in the use of spatial memory tasks to investigate episodic-like memory in mice.",
author = "Fabio Morellini",
year = "2013",
month = oct,
day = "1",
doi = "10.1007/s00441-013-1668-9",
language = "English",
volume = "354",
pages = "273--86",
journal = "CELL TISSUE RES",
issn = "0302-766X",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - Spatial memory tasks in rodents: what do they model?

AU - Morellini, Fabio

PY - 2013/10/1

Y1 - 2013/10/1

N2 - The analysis of spatial learning and memory in rodents is commonly used to investigate the mechanisms underlying certain forms of human cognition and to model their dysfunction in neuropsychiatric and neurodegenerative diseases. Proper interpretation of rodent behavior in terms of spatial memory and as a model of human cognitive functions is only possible if various navigation strategies and factors controlling the performance of the animal in a spatial task are taken into consideration. The aim of this review is to describe the experimental approaches that are being used for the study of spatial memory in rats and mice and the way that they can be interpreted in terms of general memory functions. After an introduction to the classification of memory into various categories and respective underlying neuroanatomical substrates, I explain the concept of spatial memory and its measurement in rats and mice by analysis of their navigation strategies. Subsequently, I describe the most common paradigms for spatial memory assessment with specific focus on methodological issues relevant for the correct interpretation of the results in terms of cognitive function. Finally, I present recent advances in the use of spatial memory tasks to investigate episodic-like memory in mice.

AB - The analysis of spatial learning and memory in rodents is commonly used to investigate the mechanisms underlying certain forms of human cognition and to model their dysfunction in neuropsychiatric and neurodegenerative diseases. Proper interpretation of rodent behavior in terms of spatial memory and as a model of human cognitive functions is only possible if various navigation strategies and factors controlling the performance of the animal in a spatial task are taken into consideration. The aim of this review is to describe the experimental approaches that are being used for the study of spatial memory in rats and mice and the way that they can be interpreted in terms of general memory functions. After an introduction to the classification of memory into various categories and respective underlying neuroanatomical substrates, I explain the concept of spatial memory and its measurement in rats and mice by analysis of their navigation strategies. Subsequently, I describe the most common paradigms for spatial memory assessment with specific focus on methodological issues relevant for the correct interpretation of the results in terms of cognitive function. Finally, I present recent advances in the use of spatial memory tasks to investigate episodic-like memory in mice.

U2 - 10.1007/s00441-013-1668-9

DO - 10.1007/s00441-013-1668-9

M3 - SCORING: Journal article

C2 - 23793547

VL - 354

SP - 273

EP - 286

JO - CELL TISSUE RES

JF - CELL TISSUE RES

SN - 0302-766X

IS - 1

ER -