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SORCS1 and SORCS3 control energy balance and orexigenic peptide production

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SORCS1 and SORCS3 control energy balance and orexigenic peptide production. / Subkhangulova, Aygul; Malik, Anna R; Hermey, Guido; Popp, Oliver; Dittmar, Gunnar; Rathjen, Thomas; Poy, Matthew N; Stumpf, Alexander; Beed, Prateep Sanker; Schmitz, Dietmar; Breiderhoff, Tilman; Willnow, Thomas E.

In: EMBO REP, Vol. 19, No. 4, 04.2018, p. e44810.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Subkhangulova, A, Malik, AR, Hermey, G, Popp, O, Dittmar, G, Rathjen, T, Poy, MN, Stumpf, A, Beed, PS, Schmitz, D, Breiderhoff, T & Willnow, TE 2018, 'SORCS1 and SORCS3 control energy balance and orexigenic peptide production', EMBO REP, vol. 19, no. 4, pp. e44810. https://doi.org/10.15252/embr.201744810

APA

Subkhangulova, A., Malik, A. R., Hermey, G., Popp, O., Dittmar, G., Rathjen, T., Poy, M. N., Stumpf, A., Beed, P. S., Schmitz, D., Breiderhoff, T., & Willnow, T. E. (2018). SORCS1 and SORCS3 control energy balance and orexigenic peptide production. EMBO REP, 19(4), e44810. https://doi.org/10.15252/embr.201744810

Vancouver

Subkhangulova A, Malik AR, Hermey G, Popp O, Dittmar G, Rathjen T et al. SORCS1 and SORCS3 control energy balance and orexigenic peptide production. EMBO REP. 2018 Apr;19(4):e44810. https://doi.org/10.15252/embr.201744810

Bibtex

@article{44cec5fea77541bab036c96c076a3888,
title = "SORCS1 and SORCS3 control energy balance and orexigenic peptide production",
abstract = "SORCS1 and SORCS3 are two related sorting receptors expressed in neurons of the arcuate nucleus of the hypothalamus. Using mouse models with individual or dual receptor deficiencies, we document a previously unknown function of these receptors in central control of metabolism. Specifically, SORCS1 and SORCS3 act as intracellular trafficking receptors for tropomyosin-related kinase B to attenuate signaling by brain-derived neurotrophic factor, a potent regulator of energy homeostasis. Loss of the joint action of SORCS1 and SORCS3 in mutant mice results in excessive production of the orexigenic neuropeptide agouti-related peptide and in a state of chronic energy excess characterized by enhanced food intake, decreased locomotor activity, diminished usage of lipids as metabolic fuel, and increased adiposity, albeit at overall reduced body weight. Our findings highlight a novel concept in regulation of the melanocortin system and the role played by trafficking receptors SORCS1 and SORCS3 in this process.",
keywords = "Journal Article",
author = "Aygul Subkhangulova and Malik, {Anna R} and Guido Hermey and Oliver Popp and Gunnar Dittmar and Thomas Rathjen and Poy, {Matthew N} and Alexander Stumpf and Beed, {Prateep Sanker} and Dietmar Schmitz and Tilman Breiderhoff and Willnow, {Thomas E}",
note = "{\textcopyright} 2018 The Authors. Published under the terms of the CC BY 4.0 license.",
year = "2018",
month = apr,
doi = "10.15252/embr.201744810",
language = "English",
volume = "19",
pages = "e44810",
journal = "EMBO REP",
issn = "1469-221X",
publisher = "NATURE PUBLISHING GROUP",
number = "4",

}

RIS

TY - JOUR

T1 - SORCS1 and SORCS3 control energy balance and orexigenic peptide production

AU - Subkhangulova, Aygul

AU - Malik, Anna R

AU - Hermey, Guido

AU - Popp, Oliver

AU - Dittmar, Gunnar

AU - Rathjen, Thomas

AU - Poy, Matthew N

AU - Stumpf, Alexander

AU - Beed, Prateep Sanker

AU - Schmitz, Dietmar

AU - Breiderhoff, Tilman

AU - Willnow, Thomas E

N1 - © 2018 The Authors. Published under the terms of the CC BY 4.0 license.

PY - 2018/4

Y1 - 2018/4

N2 - SORCS1 and SORCS3 are two related sorting receptors expressed in neurons of the arcuate nucleus of the hypothalamus. Using mouse models with individual or dual receptor deficiencies, we document a previously unknown function of these receptors in central control of metabolism. Specifically, SORCS1 and SORCS3 act as intracellular trafficking receptors for tropomyosin-related kinase B to attenuate signaling by brain-derived neurotrophic factor, a potent regulator of energy homeostasis. Loss of the joint action of SORCS1 and SORCS3 in mutant mice results in excessive production of the orexigenic neuropeptide agouti-related peptide and in a state of chronic energy excess characterized by enhanced food intake, decreased locomotor activity, diminished usage of lipids as metabolic fuel, and increased adiposity, albeit at overall reduced body weight. Our findings highlight a novel concept in regulation of the melanocortin system and the role played by trafficking receptors SORCS1 and SORCS3 in this process.

AB - SORCS1 and SORCS3 are two related sorting receptors expressed in neurons of the arcuate nucleus of the hypothalamus. Using mouse models with individual or dual receptor deficiencies, we document a previously unknown function of these receptors in central control of metabolism. Specifically, SORCS1 and SORCS3 act as intracellular trafficking receptors for tropomyosin-related kinase B to attenuate signaling by brain-derived neurotrophic factor, a potent regulator of energy homeostasis. Loss of the joint action of SORCS1 and SORCS3 in mutant mice results in excessive production of the orexigenic neuropeptide agouti-related peptide and in a state of chronic energy excess characterized by enhanced food intake, decreased locomotor activity, diminished usage of lipids as metabolic fuel, and increased adiposity, albeit at overall reduced body weight. Our findings highlight a novel concept in regulation of the melanocortin system and the role played by trafficking receptors SORCS1 and SORCS3 in this process.

KW - Journal Article

U2 - 10.15252/embr.201744810

DO - 10.15252/embr.201744810

M3 - SCORING: Journal article

C2 - 29440124

VL - 19

SP - e44810

JO - EMBO REP

JF - EMBO REP

SN - 1469-221X

IS - 4

ER -