Sorafenib for older patients with renal cell carcinoma: subset analysis from a randomized trial.
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Sorafenib for older patients with renal cell carcinoma: subset analysis from a randomized trial. / Eisen, Tim; Oudard, Stéphane; Szczylik, Cezary; Gravis, Gwenaelle; Heinzer, Hans; Middleton, Richard; Cihon, Frank; Anderson, Sibyl; Shah, Sonalee; Bukowski, Ronald; Escudier, Bernard.
In: JNCI-J NATL CANCER I, Vol. 100, No. 20, 20, 2008, p. 1454-1463.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Sorafenib for older patients with renal cell carcinoma: subset analysis from a randomized trial.
AU - Eisen, Tim
AU - Oudard, Stéphane
AU - Szczylik, Cezary
AU - Gravis, Gwenaelle
AU - Heinzer, Hans
AU - Middleton, Richard
AU - Cihon, Frank
AU - Anderson, Sibyl
AU - Shah, Sonalee
AU - Bukowski, Ronald
AU - Escudier, Bernard
PY - 2008
Y1 - 2008
N2 - BACKGROUND: The perception that older cancer patients may be at higher risk than younger patients of toxic effects from cancer therapy but may obtain less clinical benefit from it may be based on the underrepresentation of older patients in clinical trials and the known toxic effects of cytotoxic chemotherapy. It is not known how older patients respond to targeted therapy. METHODS: This retrospective subgroup analysis of data from the phase 3, randomized Treatment Approach in Renal Cancer Global Evaluation Trial examined the safety and efficacy of sorafenib in older (age >or=70 years, n = 115) and younger patients (age or=70 years) and younger (
AB - BACKGROUND: The perception that older cancer patients may be at higher risk than younger patients of toxic effects from cancer therapy but may obtain less clinical benefit from it may be based on the underrepresentation of older patients in clinical trials and the known toxic effects of cytotoxic chemotherapy. It is not known how older patients respond to targeted therapy. METHODS: This retrospective subgroup analysis of data from the phase 3, randomized Treatment Approach in Renal Cancer Global Evaluation Trial examined the safety and efficacy of sorafenib in older (age >or=70 years, n = 115) and younger patients (age or=70 years) and younger (
M3 - SCORING: Zeitschriftenaufsatz
VL - 100
SP - 1454
EP - 1463
JO - JNCI-J NATL CANCER I
JF - JNCI-J NATL CANCER I
SN - 0027-8874
IS - 20
M1 - 20
ER -