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Sonographic real-time imaging of tissue perfusion in a porcine haemorrhagic shock model

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Sonographic real-time imaging of tissue perfusion in a porcine haemorrhagic shock model. / Schierling, Wilma; Wipper, Sabine; Behem, Christoph R; Hinck, Daniel C; Trepte, Constantin J; Debus, Eike S; Pfister, Karin.

In: ULTRASOUND MED BIOL, Vol. 45, No. 10, 10.2019, p. 2797-2804.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schierling, W, Wipper, S, Behem, CR, Hinck, DC, Trepte, CJ, Debus, ES & Pfister, K 2019, 'Sonographic real-time imaging of tissue perfusion in a porcine haemorrhagic shock model', ULTRASOUND MED BIOL, vol. 45, no. 10, pp. 2797-2804. https://doi.org/10.1016/j.ultrasmedbio.2019.06.003

APA

Schierling, W., Wipper, S., Behem, C. R., Hinck, D. C., Trepte, C. J., Debus, E. S., & Pfister, K. (2019). Sonographic real-time imaging of tissue perfusion in a porcine haemorrhagic shock model. ULTRASOUND MED BIOL, 45(10), 2797-2804. https://doi.org/10.1016/j.ultrasmedbio.2019.06.003

Vancouver

Schierling W, Wipper S, Behem CR, Hinck DC, Trepte CJ, Debus ES et al. Sonographic real-time imaging of tissue perfusion in a porcine haemorrhagic shock model. ULTRASOUND MED BIOL. 2019 Oct;45(10):2797-2804. https://doi.org/10.1016/j.ultrasmedbio.2019.06.003

Bibtex

@article{ff2adb1684ae4402b24624a3595e9817,
title = "Sonographic real-time imaging of tissue perfusion in a porcine haemorrhagic shock model",
abstract = "Injection of fluorescence-labelled microspheres (FMs) in pigs allows only the postmortem determination of organ perfusion. Colour duplex ultrasound (CDU) and contrast-enhanced ultrasound were established as techniques for real-time imaging of tissue perfusion in a porcine haemorrhagic shock model. Haemorrhagic shock was provoked in nine domestic pigs by taking at least 15% of the calculated blood volume. Ultrasound examinations were performed with a Hitachi HI VISION Ascendus. SonoVue was injected for contrast-enhanced ultrasound. Monitoring of the resistive index and time-to-peak ratio enabled quantification of tissue perfusion in vivo during the entire study, allowing real-time differentiation of animals with systemic shock versus failing shock effect. Postmortem analyses of injected FMs confirmed the sonographic in vivo results. Determination of the resistive index and time-to-peak ratio by CDU and contrast-enhanced ultrasound allowed real-time monitoring of tissue perfusion. Effects of haemorrhagic shock and therapeutic approaches related to organ perfusion can be observed live and in vivo.",
author = "Wilma Schierling and Sabine Wipper and Behem, {Christoph R} and Hinck, {Daniel C} and Trepte, {Constantin J} and Debus, {Eike S} and Karin Pfister",
note = "Copyright {\textcopyright} 2019 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2019",
month = oct,
doi = "10.1016/j.ultrasmedbio.2019.06.003",
language = "English",
volume = "45",
pages = "2797--2804",
journal = "ULTRASOUND MED BIOL",
issn = "0301-5629",
publisher = "Elsevier USA",
number = "10",

}

RIS

TY - JOUR

T1 - Sonographic real-time imaging of tissue perfusion in a porcine haemorrhagic shock model

AU - Schierling, Wilma

AU - Wipper, Sabine

AU - Behem, Christoph R

AU - Hinck, Daniel C

AU - Trepte, Constantin J

AU - Debus, Eike S

AU - Pfister, Karin

N1 - Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2019/10

Y1 - 2019/10

N2 - Injection of fluorescence-labelled microspheres (FMs) in pigs allows only the postmortem determination of organ perfusion. Colour duplex ultrasound (CDU) and contrast-enhanced ultrasound were established as techniques for real-time imaging of tissue perfusion in a porcine haemorrhagic shock model. Haemorrhagic shock was provoked in nine domestic pigs by taking at least 15% of the calculated blood volume. Ultrasound examinations were performed with a Hitachi HI VISION Ascendus. SonoVue was injected for contrast-enhanced ultrasound. Monitoring of the resistive index and time-to-peak ratio enabled quantification of tissue perfusion in vivo during the entire study, allowing real-time differentiation of animals with systemic shock versus failing shock effect. Postmortem analyses of injected FMs confirmed the sonographic in vivo results. Determination of the resistive index and time-to-peak ratio by CDU and contrast-enhanced ultrasound allowed real-time monitoring of tissue perfusion. Effects of haemorrhagic shock and therapeutic approaches related to organ perfusion can be observed live and in vivo.

AB - Injection of fluorescence-labelled microspheres (FMs) in pigs allows only the postmortem determination of organ perfusion. Colour duplex ultrasound (CDU) and contrast-enhanced ultrasound were established as techniques for real-time imaging of tissue perfusion in a porcine haemorrhagic shock model. Haemorrhagic shock was provoked in nine domestic pigs by taking at least 15% of the calculated blood volume. Ultrasound examinations were performed with a Hitachi HI VISION Ascendus. SonoVue was injected for contrast-enhanced ultrasound. Monitoring of the resistive index and time-to-peak ratio enabled quantification of tissue perfusion in vivo during the entire study, allowing real-time differentiation of animals with systemic shock versus failing shock effect. Postmortem analyses of injected FMs confirmed the sonographic in vivo results. Determination of the resistive index and time-to-peak ratio by CDU and contrast-enhanced ultrasound allowed real-time monitoring of tissue perfusion. Effects of haemorrhagic shock and therapeutic approaches related to organ perfusion can be observed live and in vivo.

U2 - 10.1016/j.ultrasmedbio.2019.06.003

DO - 10.1016/j.ultrasmedbio.2019.06.003

M3 - SCORING: Journal article

C2 - 31277923

VL - 45

SP - 2797

EP - 2804

JO - ULTRASOUND MED BIOL

JF - ULTRASOUND MED BIOL

SN - 0301-5629

IS - 10

ER -