Somatotopic representation of nociceptive information in the putamen
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Somatotopic representation of nociceptive information in the putamen : an event-related fMRI study. / Bingel, U; Gläscher, J; Weiller, C; Büchel, C.
In: CEREB CORTEX, Vol. 14, No. 12, 01.12.2004, p. 1340-5.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Somatotopic representation of nociceptive information in the putamen
T2 - an event-related fMRI study
AU - Bingel, U
AU - Gläscher, J
AU - Weiller, C
AU - Büchel, C
PY - 2004/12/1
Y1 - 2004/12/1
N2 - The ability to locate pain plays a pivotal role in immediate defence and withdrawal behaviour. However, it is unclear to what extent nociceptive information is relayed to and processed in subcortical structures relevant for motor preparation and possibly the generation of withdrawal behaviour. We used single-trial functional magnetic resonance imaging (fMRI) to assess whether nociceptive information is represented in the putamen in a somatotopic manner. We therefore applied thulium-YAG laser-evoked pain stimuli, which had no concomitant tactile component, to the dorsum of the left hand and foot to 15 healthy subjects in a randomized order. In addition, 11 subjects were stimulated on the right body side. Differential representations of hand- and foot-related blood oxygen level dependent (BOLD) responses within the putamen were assessed using a single subject approach. Nociceptive stimuli significantly activated the putamen bilaterally. However, a somatotopic organization for hand- and foot-related responses was only present in the contralateral putamen. Here the foot was located anteriorly and medially to the hand, which parallels results from anatomical and microstimulation studies in monkeys and also human imaging data on the arrangement of movement related activity in the putamen. This result provides evidence for the hypothesis that behaviourally relevant nociceptive information without additional information from the tactile system is represented in the putamen and made available for pain related motor responses.
AB - The ability to locate pain plays a pivotal role in immediate defence and withdrawal behaviour. However, it is unclear to what extent nociceptive information is relayed to and processed in subcortical structures relevant for motor preparation and possibly the generation of withdrawal behaviour. We used single-trial functional magnetic resonance imaging (fMRI) to assess whether nociceptive information is represented in the putamen in a somatotopic manner. We therefore applied thulium-YAG laser-evoked pain stimuli, which had no concomitant tactile component, to the dorsum of the left hand and foot to 15 healthy subjects in a randomized order. In addition, 11 subjects were stimulated on the right body side. Differential representations of hand- and foot-related blood oxygen level dependent (BOLD) responses within the putamen were assessed using a single subject approach. Nociceptive stimuli significantly activated the putamen bilaterally. However, a somatotopic organization for hand- and foot-related responses was only present in the contralateral putamen. Here the foot was located anteriorly and medially to the hand, which parallels results from anatomical and microstimulation studies in monkeys and also human imaging data on the arrangement of movement related activity in the putamen. This result provides evidence for the hypothesis that behaviourally relevant nociceptive information without additional information from the tactile system is represented in the putamen and made available for pain related motor responses.
KW - Adult
KW - Evoked Potentials
KW - Female
KW - Humans
KW - Magnetic Resonance Imaging
KW - Male
KW - Pain Measurement
KW - Putamen
U2 - 10.1093/cercor/bhh094
DO - 10.1093/cercor/bhh094
M3 - SCORING: Journal article
C2 - 15217895
VL - 14
SP - 1340
EP - 1345
JO - CEREB CORTEX
JF - CEREB CORTEX
SN - 1047-3211
IS - 12
ER -