In this report, we present the results of a multicenter study to test analytic and diagnostic performance of soluble forms of amyloid precursor proteins alpha and beta (sAPPalpha and sAPPbeta) in the cerebrospinal fluid (CSF) of patients with different forms of dementing conditions. CSF samples were collected from 188 patients with early dementia (mini-mental state examination>/=20 in majority of cases) and mild cognitive impairment (MCI) in 12 gerontopsychiatric centers, and the clinical diagnoses were supported by neurochemical dementia diagnostic (NDD) tools: CSF amyloidbeta peptides, Tau and phospho-Tau. sAPPalpha and sAPPbeta were measured with multiplexing method based on electrochemiluminescence. sAPPalpha and sAPPbeta CSF concentrations correlated with each other with very high correlation ratio (R=0.96, P
