Social Activities and Risk of Dementia in Community-Dwelling Older People: Gender-Specific Findings from a Prospective Cohort Study
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Social Activities and Risk of Dementia in Community-Dwelling Older People: Gender-Specific Findings from a Prospective Cohort Study. / Htun, Htet Lin; Teshale, Achamyeleh Birhanu; Owen, Alice J; Ryan, Joanne; Woods, Robyn L; Orchard, Suzanne G; Hajek, André; Lysen, Thom; Shah, Raj C; Chong, Trevor T-J; Sheets, Kerry M; Joyce, Johanna; Murray, Anne M; Freak-Poli, Rosanne.
In: J GERONTOL B-PSYCHOL, Vol. 79, No. 5, 01.05.2024, p. gbae050.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Social Activities and Risk of Dementia in Community-Dwelling Older People: Gender-Specific Findings from a Prospective Cohort Study
AU - Htun, Htet Lin
AU - Teshale, Achamyeleh Birhanu
AU - Owen, Alice J
AU - Ryan, Joanne
AU - Woods, Robyn L
AU - Orchard, Suzanne G
AU - Hajek, André
AU - Lysen, Thom
AU - Shah, Raj C
AU - Chong, Trevor T-J
AU - Sheets, Kerry M
AU - Joyce, Johanna
AU - Murray, Anne M
AU - Freak-Poli, Rosanne
N1 - © The Author(s) 2024. Published by Oxford University Press on behalf of The Gerontological Society of America.
PY - 2024/5/1
Y1 - 2024/5/1
N2 - OBJECTIVES: This study examines the gender-specific associations between a wide range of social activities and dementia risk.METHODS: A prospective cohort study was conducted involving community-dwelling older Australians (≥70 years) without significant cognitive impairment at enrolment. During the first year of enrolment, we assessed 25 self-reported social activities covering various aspects, including support from relatives and friends, community participation, social interactions with surroundings, and loneliness. Dementia diagnosis followed DSM-IV criteria, adjudicated by an international expert panel. To estimate hazard ratios (HR) and 95% confidence intervals (CI) for associations between social activities and dementia, we performed Cox proportional hazards models, adjusting for age, educational attainment, baseline global cognition, and depressive symptoms.RESULTS: Among 9,936 participants who completed all social activity questionnaires (median [IQR] age: 73.4 [71.6-77.1] years; 47.4% men), dementia was diagnosed in 3.8% of men (n = 181/4,705) and 2.6% of women (n = 138/5,231) over a median 6.4 years (IQR: 5.3-7.6, range: 0.2-10.1) follow-up. Gender-specific relationships emerged: caregiving for a person with illness/disability in women (HR: 0.65, 95% CI: 0.42-0.99), and having ≥9 relatives feeling close to call for help in men (HR: 0.56, 95% CI: 0.33-0.96; reference <9 relatives) were associated with reduced dementia risk. Unexpectedly, in women, having ≥5 friends with whom they felt comfortable discussing private matters were associated with a greater dementia risk (HR: 1.69, 95% CI: 1.10-2.59; reference ≤2 friends). Imputed models further identified that babysitting/childminding was associated with lower dementia risk in men (HR: 0.75, 95% CI: 0.56-0.99). No other social activities showed significant associations with dementia.DISCUSSION: This study provides evidence of social activities influencing dementia risk. Further investigations are required to uncover the mechanisms driving these observed relationships.
AB - OBJECTIVES: This study examines the gender-specific associations between a wide range of social activities and dementia risk.METHODS: A prospective cohort study was conducted involving community-dwelling older Australians (≥70 years) without significant cognitive impairment at enrolment. During the first year of enrolment, we assessed 25 self-reported social activities covering various aspects, including support from relatives and friends, community participation, social interactions with surroundings, and loneliness. Dementia diagnosis followed DSM-IV criteria, adjudicated by an international expert panel. To estimate hazard ratios (HR) and 95% confidence intervals (CI) for associations between social activities and dementia, we performed Cox proportional hazards models, adjusting for age, educational attainment, baseline global cognition, and depressive symptoms.RESULTS: Among 9,936 participants who completed all social activity questionnaires (median [IQR] age: 73.4 [71.6-77.1] years; 47.4% men), dementia was diagnosed in 3.8% of men (n = 181/4,705) and 2.6% of women (n = 138/5,231) over a median 6.4 years (IQR: 5.3-7.6, range: 0.2-10.1) follow-up. Gender-specific relationships emerged: caregiving for a person with illness/disability in women (HR: 0.65, 95% CI: 0.42-0.99), and having ≥9 relatives feeling close to call for help in men (HR: 0.56, 95% CI: 0.33-0.96; reference <9 relatives) were associated with reduced dementia risk. Unexpectedly, in women, having ≥5 friends with whom they felt comfortable discussing private matters were associated with a greater dementia risk (HR: 1.69, 95% CI: 1.10-2.59; reference ≤2 friends). Imputed models further identified that babysitting/childminding was associated with lower dementia risk in men (HR: 0.75, 95% CI: 0.56-0.99). No other social activities showed significant associations with dementia.DISCUSSION: This study provides evidence of social activities influencing dementia risk. Further investigations are required to uncover the mechanisms driving these observed relationships.
U2 - 10.1093/geronb/gbae050
DO - 10.1093/geronb/gbae050
M3 - SCORING: Journal article
C2 - 38567686
VL - 79
SP - gbae050
JO - J GERONTOL B-PSYCHOL
JF - J GERONTOL B-PSYCHOL
SN - 1079-5014
IS - 5
ER -
