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SNW1 is a prognostic biomarker in prostate cancer

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SNW1 is a prognostic biomarker in prostate cancer. / Höflmayer, Doris; Willich, Carla; Hube-Magg, Claudia; Simon, Ronald; Lang, Dagmar; Neubauer, Emily; Jacobsen, Frank; Hinsch, Andrea; Luebke, Andreas M; Tsourlakis, Marie Christina; Huland, Hartwig; Graefen, Markus; Haese, Alexander; Heinzer, Hans; Minner, Sarah; Büscheck, Franziska; Sauter, Guido; Schlomm, Thorsten; Steurer, Stefan; Clauditz, Till S; Burandt, Eike; Wilczak, Waldemar; Bernreuther, Christian.

In: DIAGN PATHOL, Vol. 14, No. 1, 01.05.2019, p. 33.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Höflmayer, D, Willich, C, Hube-Magg, C, Simon, R, Lang, D, Neubauer, E, Jacobsen, F, Hinsch, A, Luebke, AM, Tsourlakis, MC, Huland, H, Graefen, M, Haese, A, Heinzer, H, Minner, S, Büscheck, F, Sauter, G, Schlomm, T, Steurer, S, Clauditz, TS, Burandt, E, Wilczak, W & Bernreuther, C 2019, 'SNW1 is a prognostic biomarker in prostate cancer', DIAGN PATHOL, vol. 14, no. 1, pp. 33. https://doi.org/10.1186/s13000-019-0810-8

APA

Höflmayer, D., Willich, C., Hube-Magg, C., Simon, R., Lang, D., Neubauer, E., Jacobsen, F., Hinsch, A., Luebke, A. M., Tsourlakis, M. C., Huland, H., Graefen, M., Haese, A., Heinzer, H., Minner, S., Büscheck, F., Sauter, G., Schlomm, T., Steurer, S., ... Bernreuther, C. (2019). SNW1 is a prognostic biomarker in prostate cancer. DIAGN PATHOL, 14(1), 33. https://doi.org/10.1186/s13000-019-0810-8

Vancouver

Höflmayer D, Willich C, Hube-Magg C, Simon R, Lang D, Neubauer E et al. SNW1 is a prognostic biomarker in prostate cancer. DIAGN PATHOL. 2019 May 1;14(1):33. https://doi.org/10.1186/s13000-019-0810-8

Bibtex

@article{cf239e6f28a14ca5a917c195321822ab,
title = "SNW1 is a prognostic biomarker in prostate cancer",
abstract = "BACKGROUND: SNW1 is a nuclear receptor co-activator involved in splicing and transcription control, including androgen receptor signaling. Overexpression of SNW1 has been linked to adverse prognosis in different cancer types, but studies on the role of SNW1 in prostate cancer are lacking.METHODS: Using immunohistochemistry, we analyzed SNW1 expression in 10,310 prostate cancers in a tissue microarray (TMA) with attached clinical and molecular data.RESULTS: The comparison with normal prostate tissue revealed an up regulation of SNW1 in a subset of cancer samples. SNW1 staining was considered weak in 31.5%, moderate in 37.7% and strong in 14% of cancers. Strong SNW1 expression was markedly more frequent in prostate cancers harboring the TMPRSS2:ERG fusion (24%) than in ERG negative cancers (7%, p < 0.0001). Significant associations with Gleason grade, stage, nodal status and early biochemical recurrence were observed in the ERG negative and positive subset. Multivariable modeling revealed that the prognostic value of SNW1 up regulation was independent from the established preoperative histopathological and clinical parameters.CONCLUSION: These results demonstrate that SNW1 overexpression is an independent prognostic marker in prostate cancer with potential clinical utility.",
author = "Doris H{\"o}flmayer and Carla Willich and Claudia Hube-Magg and Ronald Simon and Dagmar Lang and Emily Neubauer and Frank Jacobsen and Andrea Hinsch and Luebke, {Andreas M} and Tsourlakis, {Marie Christina} and Hartwig Huland and Markus Graefen and Alexander Haese and Hans Heinzer and Sarah Minner and Franziska B{\"u}scheck and Guido Sauter and Thorsten Schlomm and Stefan Steurer and Clauditz, {Till S} and Eike Burandt and Waldemar Wilczak and Christian Bernreuther",
year = "2019",
month = may,
day = "1",
doi = "10.1186/s13000-019-0810-8",
language = "English",
volume = "14",
pages = "33",
journal = "DIAGN PATHOL",
issn = "1746-1596",
publisher = "BioMed Central Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - SNW1 is a prognostic biomarker in prostate cancer

AU - Höflmayer, Doris

AU - Willich, Carla

AU - Hube-Magg, Claudia

AU - Simon, Ronald

AU - Lang, Dagmar

AU - Neubauer, Emily

AU - Jacobsen, Frank

AU - Hinsch, Andrea

AU - Luebke, Andreas M

AU - Tsourlakis, Marie Christina

AU - Huland, Hartwig

AU - Graefen, Markus

AU - Haese, Alexander

AU - Heinzer, Hans

AU - Minner, Sarah

AU - Büscheck, Franziska

AU - Sauter, Guido

AU - Schlomm, Thorsten

AU - Steurer, Stefan

AU - Clauditz, Till S

AU - Burandt, Eike

AU - Wilczak, Waldemar

AU - Bernreuther, Christian

PY - 2019/5/1

Y1 - 2019/5/1

N2 - BACKGROUND: SNW1 is a nuclear receptor co-activator involved in splicing and transcription control, including androgen receptor signaling. Overexpression of SNW1 has been linked to adverse prognosis in different cancer types, but studies on the role of SNW1 in prostate cancer are lacking.METHODS: Using immunohistochemistry, we analyzed SNW1 expression in 10,310 prostate cancers in a tissue microarray (TMA) with attached clinical and molecular data.RESULTS: The comparison with normal prostate tissue revealed an up regulation of SNW1 in a subset of cancer samples. SNW1 staining was considered weak in 31.5%, moderate in 37.7% and strong in 14% of cancers. Strong SNW1 expression was markedly more frequent in prostate cancers harboring the TMPRSS2:ERG fusion (24%) than in ERG negative cancers (7%, p < 0.0001). Significant associations with Gleason grade, stage, nodal status and early biochemical recurrence were observed in the ERG negative and positive subset. Multivariable modeling revealed that the prognostic value of SNW1 up regulation was independent from the established preoperative histopathological and clinical parameters.CONCLUSION: These results demonstrate that SNW1 overexpression is an independent prognostic marker in prostate cancer with potential clinical utility.

AB - BACKGROUND: SNW1 is a nuclear receptor co-activator involved in splicing and transcription control, including androgen receptor signaling. Overexpression of SNW1 has been linked to adverse prognosis in different cancer types, but studies on the role of SNW1 in prostate cancer are lacking.METHODS: Using immunohistochemistry, we analyzed SNW1 expression in 10,310 prostate cancers in a tissue microarray (TMA) with attached clinical and molecular data.RESULTS: The comparison with normal prostate tissue revealed an up regulation of SNW1 in a subset of cancer samples. SNW1 staining was considered weak in 31.5%, moderate in 37.7% and strong in 14% of cancers. Strong SNW1 expression was markedly more frequent in prostate cancers harboring the TMPRSS2:ERG fusion (24%) than in ERG negative cancers (7%, p < 0.0001). Significant associations with Gleason grade, stage, nodal status and early biochemical recurrence were observed in the ERG negative and positive subset. Multivariable modeling revealed that the prognostic value of SNW1 up regulation was independent from the established preoperative histopathological and clinical parameters.CONCLUSION: These results demonstrate that SNW1 overexpression is an independent prognostic marker in prostate cancer with potential clinical utility.

U2 - 10.1186/s13000-019-0810-8

DO - 10.1186/s13000-019-0810-8

M3 - SCORING: Journal article

C2 - 31043167

VL - 14

SP - 33

JO - DIAGN PATHOL

JF - DIAGN PATHOL

SN - 1746-1596

IS - 1

ER -