Sleep EEG effects of anti-gluco- and anti-mineralocorticoids in old-aged men: pilot study

Cüneyt Demiralay; Agorastos Agorastos; Axel Steiger; Klaus Wiedemann

doi:10.1111/pcn.12142

Sleep EEG effects of anti-gluco- and anti-mineralocorticoids in old-aged men: pilot study

Standard

Sleep EEG effects of anti-gluco- and anti-mineralocorticoids in old-aged men: pilot study. / Demiralay, Cüneyt; Agorastos, Agorastos; Steiger, Axel; Wiedemann, Klaus.

In: PSYCHIAT CLIN NEUROS, Vol. 68, No. 5, 01.05.2014, p. 383-7.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Demiralay, C, Agorastos, A, Steiger, A & Wiedemann, K 2014, 'Sleep EEG effects of anti-gluco- and anti-mineralocorticoids in old-aged men: pilot study', PSYCHIAT CLIN NEUROS, vol. 68, no. 5, pp. 383-7. https://doi.org/10.1111/pcn.12142

APA

Demiralay, C., Agorastos, A., Steiger, A., & Wiedemann, K. (2014). Sleep EEG effects of anti-gluco- and anti-mineralocorticoids in old-aged men: pilot study. PSYCHIAT CLIN NEUROS, 68(5), 383-7. https://doi.org/10.1111/pcn.12142

Vancouver

Demiralay C, Agorastos A, Steiger A, Wiedemann K. Sleep EEG effects of anti-gluco- and anti-mineralocorticoids in old-aged men: pilot study. PSYCHIAT CLIN NEUROS. 2014 May 1;68(5):383-7. https://doi.org/10.1111/pcn.12142

Bibtex

@article{b4d912f2c9994744b3dac5c4ba6b58b7,

title = "Sleep EEG effects of anti-gluco- and anti-mineralocorticoids in old-aged men: pilot study",

abstract = "AIM: Age-related sleep changes have been associated with altered hypothalamic-pituitary-adrenal axis reactivity and impaired feedback inhibition at the glucocorticoid (GR) and mineralocorticoid (MR) receptor level. To further investigate the specific role of this binary receptor system in the elderly, sleep electroencephalogram (EEG) effects of the MR antagonist spironolactone and GR antagonist mifepristone in old-aged men were compared in this pilot study.METHODS: Old-aged healthy men (n = 6, 65-91 years) were treated on three occasions in a single-blinded design in random order with mifepristone, spironolactone and placebo, respectively, and nocturnal sleep EEG was recorded.RESULTS: Mifepristone led to increased wake time, decreased stage 2 and rapid eye movement (REM) sleep and prolonged REM sleep latency in the first half of the night, whereas spironolactone had no considerable effects on sleep EEG.CONCLUSION: GR antagonism can potentiate age-related sleep pattern alterations and further support the role of impaired GR signaling in age-related changes in sleep architecture.",

author = "C{\"u}neyt Demiralay and Agorastos Agorastos and Axel Steiger and Klaus Wiedemann",

note = "{\textcopyright} 2014 The Authors. Psychiatry and Clinical Neurosciences {\textcopyright} 2014 Japanese Society of Psychiatry and Neurology.",

year = "2014",

month = may,

day = "1",

doi = "10.1111/pcn.12142",

language = "English",

volume = "68",

pages = "383--7",

journal = "PSYCHIAT CLIN NEUROS",

issn = "1323-1316",

publisher = "Wiley-Blackwell",

number = "5",

}

RIS

TY - JOUR

T1 - Sleep EEG effects of anti-gluco- and anti-mineralocorticoids in old-aged men: pilot study

AU - Demiralay, Cüneyt

AU - Agorastos, Agorastos

AU - Steiger, Axel

AU - Wiedemann, Klaus

PY - 2014/5/1

Y1 - 2014/5/1

N2 - AIM: Age-related sleep changes have been associated with altered hypothalamic-pituitary-adrenal axis reactivity and impaired feedback inhibition at the glucocorticoid (GR) and mineralocorticoid (MR) receptor level. To further investigate the specific role of this binary receptor system in the elderly, sleep electroencephalogram (EEG) effects of the MR antagonist spironolactone and GR antagonist mifepristone in old-aged men were compared in this pilot study.METHODS: Old-aged healthy men (n = 6, 65-91 years) were treated on three occasions in a single-blinded design in random order with mifepristone, spironolactone and placebo, respectively, and nocturnal sleep EEG was recorded.RESULTS: Mifepristone led to increased wake time, decreased stage 2 and rapid eye movement (REM) sleep and prolonged REM sleep latency in the first half of the night, whereas spironolactone had no considerable effects on sleep EEG.CONCLUSION: GR antagonism can potentiate age-related sleep pattern alterations and further support the role of impaired GR signaling in age-related changes in sleep architecture.

AB - AIM: Age-related sleep changes have been associated with altered hypothalamic-pituitary-adrenal axis reactivity and impaired feedback inhibition at the glucocorticoid (GR) and mineralocorticoid (MR) receptor level. To further investigate the specific role of this binary receptor system in the elderly, sleep electroencephalogram (EEG) effects of the MR antagonist spironolactone and GR antagonist mifepristone in old-aged men were compared in this pilot study.METHODS: Old-aged healthy men (n = 6, 65-91 years) were treated on three occasions in a single-blinded design in random order with mifepristone, spironolactone and placebo, respectively, and nocturnal sleep EEG was recorded.RESULTS: Mifepristone led to increased wake time, decreased stage 2 and rapid eye movement (REM) sleep and prolonged REM sleep latency in the first half of the night, whereas spironolactone had no considerable effects on sleep EEG.CONCLUSION: GR antagonism can potentiate age-related sleep pattern alterations and further support the role of impaired GR signaling in age-related changes in sleep architecture.

U2 - 10.1111/pcn.12142

DO - 10.1111/pcn.12142

M3 - SCORING: Journal article

C2 - 24397408

VL - 68

SP - 383

EP - 387

JO - PSYCHIAT CLIN NEUROS

JF - PSYCHIAT CLIN NEUROS

SN - 1323-1316

IS - 5

ER -