Sleep deprivation: effects on circadian rhythms of rat brain neurotransmitter receptors.
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Sleep deprivation: effects on circadian rhythms of rat brain neurotransmitter receptors. / Wirz-Justice, A; Tobler, I; Kafka, M S; Naber, Dieter; Marangos, P J; Borbély, A A; Wehr, T A.
In: PSYCHIAT RES, Vol. 5, No. 1, 1, 1981, p. 67-76.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Sleep deprivation: effects on circadian rhythms of rat brain neurotransmitter receptors.
AU - Wirz-Justice, A
AU - Tobler, I
AU - Kafka, M S
AU - Naber, Dieter
AU - Marangos, P J
AU - Borbély, A A
AU - Wehr, T A
PY - 1981
Y1 - 1981
N2 - Specific binding of ligand to rat forebrain alpha- and beta-adrenergic, muscarinic cholinergic, opiate, benzodiazepine, and striatal dopamine receptors was measured at 4-hour intervals during the last 13 hours of a 24-hour sleep deprivation period, and during the first 11 hours of the recovery sleep period. In non-sleep-deprived controls a 24-hour rhythm in binding was evident. The minor differences between the sleep deprivation group and the control group consisted mainly in a reduced amplitude of the 24-hour rhythm under the sleep deprivation schedule. The results indicate that neither the 24-hour forced locomotion nor the subsequent prominent sleep rebound is accompanied by marked changes in the number of neurotransmitter receptors and their circadian rhythms.
AB - Specific binding of ligand to rat forebrain alpha- and beta-adrenergic, muscarinic cholinergic, opiate, benzodiazepine, and striatal dopamine receptors was measured at 4-hour intervals during the last 13 hours of a 24-hour sleep deprivation period, and during the first 11 hours of the recovery sleep period. In non-sleep-deprived controls a 24-hour rhythm in binding was evident. The minor differences between the sleep deprivation group and the control group consisted mainly in a reduced amplitude of the 24-hour rhythm under the sleep deprivation schedule. The results indicate that neither the 24-hour forced locomotion nor the subsequent prominent sleep rebound is accompanied by marked changes in the number of neurotransmitter receptors and their circadian rhythms.
M3 - SCORING: Zeitschriftenaufsatz
VL - 5
SP - 67
EP - 76
JO - PSYCHIAT RES
JF - PSYCHIAT RES
SN - 0165-1781
IS - 1
M1 - 1
ER -
