Site-1 and site-2 proteases: A team of two in regulated proteolysis

Tatyana Danyukova; Kenneth Schöneck; Sandra Pohl

doi:10.1016/j.bbamcr.2021.119138

Site-1 and site-2 proteases: A team of two in regulated proteolysis

Standard

Site-1 and site-2 proteases: A team of two in regulated proteolysis. / Danyukova, Tatyana ; Schöneck, Kenneth ; Pohl, Sandra.

In: BBA-MOL CELL RES, Vol. 1869, No. 1, 01.2022, p. 119138.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Danyukova, T , Schöneck, K & Pohl, S 2022, 'Site-1 and site-2 proteases: A team of two in regulated proteolysis', BBA-MOL CELL RES, vol. 1869, no. 1, pp. 119138. https://doi.org/10.1016/j.bbamcr.2021.119138

APA

Danyukova, T., Schöneck, K., & Pohl, S. (2022). Site-1 and site-2 proteases: A team of two in regulated proteolysis. BBA-MOL CELL RES, 1869(1), 119138. https://doi.org/10.1016/j.bbamcr.2021.119138

Vancouver

Danyukova T , Schöneck K , Pohl S. Site-1 and site-2 proteases: A team of two in regulated proteolysis. BBA-MOL CELL RES. 2022 Jan;1869(1):119138. https://doi.org/10.1016/j.bbamcr.2021.119138

Bibtex

@article{67e674bd71b84ea5be33a7e7cd49c600,

title = "Site-1 and site-2 proteases: A team of two in regulated proteolysis",

abstract = "The site-1 and site-2 proteases (S1P and S2P) were identified over 20 years ago, and the functions of both have been addressed in numerous studies ever since. Whereas S1P processes a set of substrates independently of S2P, the latter acts in concert with S1P in a mechanism, called regulated intramembrane proteolysis, that controls lipid metabolism and response to unfolded proteins. This review summarizes the molecular roles that S1P and S2P jointly play in these processes. As S1P and S2P deficiencies mainly affect connective tissues, yet with varying phenotypes, we discuss the segregated functions of S1P and S2P in terms of cell homeostasis and maintenance of the connective tissues. In addition, we provide experimental data that point at S2P, but not S1P, as a critical regulator of cell adaptation to proteotoxicity or lipid imbalance. Therefore, we hypothesize that S2P can also function independently of S1P activity.",

author = "Tatyana Danyukova and Kenneth Sch{\"o}neck and Sandra Pohl",

year = "2022",

month = jan,

doi = "10.1016/j.bbamcr.2021.119138",

language = "English",

volume = "1869",

pages = "119138",

journal = "BBA-MOL CELL RES",

issn = "0167-4889",

publisher = "Elsevier",

number = "1",

}

RIS

TY - JOUR

T1 - Site-1 and site-2 proteases: A team of two in regulated proteolysis

AU - Danyukova, Tatyana

AU - Schöneck, Kenneth

AU - Pohl, Sandra

PY - 2022/1

Y1 - 2022/1

N2 - The site-1 and site-2 proteases (S1P and S2P) were identified over 20 years ago, and the functions of both have been addressed in numerous studies ever since. Whereas S1P processes a set of substrates independently of S2P, the latter acts in concert with S1P in a mechanism, called regulated intramembrane proteolysis, that controls lipid metabolism and response to unfolded proteins. This review summarizes the molecular roles that S1P and S2P jointly play in these processes. As S1P and S2P deficiencies mainly affect connective tissues, yet with varying phenotypes, we discuss the segregated functions of S1P and S2P in terms of cell homeostasis and maintenance of the connective tissues. In addition, we provide experimental data that point at S2P, but not S1P, as a critical regulator of cell adaptation to proteotoxicity or lipid imbalance. Therefore, we hypothesize that S2P can also function independently of S1P activity.

AB - The site-1 and site-2 proteases (S1P and S2P) were identified over 20 years ago, and the functions of both have been addressed in numerous studies ever since. Whereas S1P processes a set of substrates independently of S2P, the latter acts in concert with S1P in a mechanism, called regulated intramembrane proteolysis, that controls lipid metabolism and response to unfolded proteins. This review summarizes the molecular roles that S1P and S2P jointly play in these processes. As S1P and S2P deficiencies mainly affect connective tissues, yet with varying phenotypes, we discuss the segregated functions of S1P and S2P in terms of cell homeostasis and maintenance of the connective tissues. In addition, we provide experimental data that point at S2P, but not S1P, as a critical regulator of cell adaptation to proteotoxicity or lipid imbalance. Therefore, we hypothesize that S2P can also function independently of S1P activity.

U2 - 10.1016/j.bbamcr.2021.119138

DO - 10.1016/j.bbamcr.2021.119138

M3 - SCORING: Review article

C2 - 34619164

VL - 1869

SP - 119138

JO - BBA-MOL CELL RES

JF - BBA-MOL CELL RES

SN - 0167-4889

IS - 1

ER -