SIOP-CPT-2000 update
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SIOP-CPT-2000 update. / Kordes, U.; Kutluk, T.; Hasselblatt, M.; Pietsch, A. Mahajan T.; Thall, P.; Wolff, J.E.
62. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC) Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgen (PNCH). 2011.Research output: SCORING: Contribution to book/anthology › Conference contribution - Article for conference › Research
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TY - CHAP
T1 - SIOP-CPT-2000 update
AU - Kordes, U.
AU - Kutluk, T.
AU - Hasselblatt, M.
AU - Pietsch, A. Mahajan T.
AU - Thall, P.
AU - Wolff, J.E.
N1 - q
PY - 2011
Y1 - 2011
N2 - Objective: Presentation of the updated interim analyis of the CPT-SIOP-2000 study Methods: Interim analyis of the CPT-SIOP-2000 study Results: Very rare tumors such as choroid plexus tumors require large referral populations to generate meaningful clinical data. In the year 2000, the international Society of Pediatric Oncology, SIOP started a program including a prospective registry, a standard of care recommendation, and a randomized treatment protocol (CPT-SIOP-2000). Data of 188 tumors were registered by February 2010 from 173 patients, 15 of whom had two subsequent tumors documented. 83 of these patients were registered from Germany. 84 were male, the mean age was 4.1 years (range 0.1–45), 57 had choroid plexus papilloma, 48 atypical choroid plexus papilloma, and 57 choroid plexus carcinoma, 10 histologies could not be classified. 39.1% were located in each of the lateral ventricles, 6.1% in the third ventricle, 11.7% in the fourth ventricle, 1.8% in the CP-angle, and 1.2% had multiple locations. Complete resection was achieved in 75.5 The 5-year OS of 163 patients with classified histology was 84.5% (SE 4.4, and 5Y-EFS was 65.1 (SE 5.4. The prognostic relevance of the histology and radiation was confirmed as previously described. However, the prognostic relevance of surgical resection disappeared when covariates of histology and radiation were used in COX regression analyses. Conclusions: Two chemotherapy protocols (analyzed as blinded dataset) did not differ in outcome results, but the final analysis is not planned until 2015.
AB - Objective: Presentation of the updated interim analyis of the CPT-SIOP-2000 study Methods: Interim analyis of the CPT-SIOP-2000 study Results: Very rare tumors such as choroid plexus tumors require large referral populations to generate meaningful clinical data. In the year 2000, the international Society of Pediatric Oncology, SIOP started a program including a prospective registry, a standard of care recommendation, and a randomized treatment protocol (CPT-SIOP-2000). Data of 188 tumors were registered by February 2010 from 173 patients, 15 of whom had two subsequent tumors documented. 83 of these patients were registered from Germany. 84 were male, the mean age was 4.1 years (range 0.1–45), 57 had choroid plexus papilloma, 48 atypical choroid plexus papilloma, and 57 choroid plexus carcinoma, 10 histologies could not be classified. 39.1% were located in each of the lateral ventricles, 6.1% in the third ventricle, 11.7% in the fourth ventricle, 1.8% in the CP-angle, and 1.2% had multiple locations. Complete resection was achieved in 75.5 The 5-year OS of 163 patients with classified histology was 84.5% (SE 4.4, and 5Y-EFS was 65.1 (SE 5.4. The prognostic relevance of the histology and radiation was confirmed as previously described. However, the prognostic relevance of surgical resection disappeared when covariates of histology and radiation were used in COX regression analyses. Conclusions: Two chemotherapy protocols (analyzed as blinded dataset) did not differ in outcome results, but the final analysis is not planned until 2015.
KW - conf, cpt, qot
U2 - 10.3205/11dgnc146
DO - 10.3205/11dgnc146
M3 - Conference contribution - Article for conference
BT - 62. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC) Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgen (PNCH)
ER -
