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Single-Dose Effects of Citalopram on Neural Responses to Affective Stimuli in Borderline Personality Disorder: A Randomized Clinical Trial

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Single-Dose Effects of Citalopram on Neural Responses to Affective Stimuli in Borderline Personality Disorder: A Randomized Clinical Trial. / Paret, Christian; Niedtfeld, Inga; Lotter, Tobias; Wunder, Andreas; Grimm, Simone; Mennes, Maarten; Okell, Thomas; Beckmann, Christian; Schmahl, Christian.

In: BIOL PSYCHIAT-COGN N, Vol. 6, No. 8, 08.2021, p. 837-845.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Paret, C, Niedtfeld, I, Lotter, T, Wunder, A, Grimm, S, Mennes, M, Okell, T, Beckmann, C & Schmahl, C 2021, 'Single-Dose Effects of Citalopram on Neural Responses to Affective Stimuli in Borderline Personality Disorder: A Randomized Clinical Trial', BIOL PSYCHIAT-COGN N, vol. 6, no. 8, pp. 837-845. https://doi.org/10.1016/j.bpsc.2021.02.002

APA

Paret, C., Niedtfeld, I., Lotter, T., Wunder, A., Grimm, S., Mennes, M., Okell, T., Beckmann, C., & Schmahl, C. (2021). Single-Dose Effects of Citalopram on Neural Responses to Affective Stimuli in Borderline Personality Disorder: A Randomized Clinical Trial. BIOL PSYCHIAT-COGN N, 6(8), 837-845. https://doi.org/10.1016/j.bpsc.2021.02.002

Vancouver

Paret C, Niedtfeld I, Lotter T, Wunder A, Grimm S, Mennes M et al. Single-Dose Effects of Citalopram on Neural Responses to Affective Stimuli in Borderline Personality Disorder: A Randomized Clinical Trial. BIOL PSYCHIAT-COGN N. 2021 Aug;6(8):837-845. https://doi.org/10.1016/j.bpsc.2021.02.002

Bibtex

@article{47896a6e91d141b7ad456decacb0d06d,
title = "Single-Dose Effects of Citalopram on Neural Responses to Affective Stimuli in Borderline Personality Disorder: A Randomized Clinical Trial",
abstract = "BACKGROUND: Psychiatric medication that has a soothing effect on limbic responses to affective stimuli could improve affective instability symptoms as observed in borderline personality disorder (BPD). The objective of this study was to investigate whether citalopram versus placebo reduces the response of the affective neural circuitry during an emotional challenge.METHODS: A total of 30 female individuals with a BPD diagnosis participated in a placebo-controlled, double-blind crossover trial design. Three hours after oral drug intake, individuals with BPD viewed affective pictures while undergoing functional magnetic resonance imaging. Blood oxygen level-dependent responses to images of negative affective scenes and faces showing negative emotional expressions were assessed in regions of interest (amygdala, anterior cingulate cortex, anterior insula, dorsolateral prefrontal cortex). Blood perfusion at rest was assessed with arterial spin labeling.RESULTS: The neural response to pictures showing negative affective scenes was not significantly affected by citalopram (n = 23). Citalopram significantly reduced the amygdala response to pictures of faces with negative affective expressions (n = 25, treatment difference left hemisphere: -0.06 ± 0.16, p < .05; right hemisphere: -0.06 ± 0.17, p < .05). We observed no significant effects of citalopram on the other regions. The drug did not significantly alter blood perfusion at rest.CONCLUSIONS: Citalopram can alter the amygdala response to affective stimuli in BPD, which is characterized by overly responsive affective neural circuitry.",
keywords = "Amygdala, Borderline Personality Disorder/drug therapy, Citalopram/pharmacology, Emotions, Female, Humans, Magnetic Resonance Imaging",
author = "Christian Paret and Inga Niedtfeld and Tobias Lotter and Andreas Wunder and Simone Grimm and Maarten Mennes and Thomas Okell and Christian Beckmann and Christian Schmahl",
note = "Copyright {\textcopyright} 2021 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.",
year = "2021",
month = aug,
doi = "10.1016/j.bpsc.2021.02.002",
language = "English",
volume = "6",
pages = "837--845",
journal = "BIOL PSYCHIAT-COGN N",
issn = "2451-9022",
publisher = "Elsevier Inc.",
number = "8",

}

RIS

TY - JOUR

T1 - Single-Dose Effects of Citalopram on Neural Responses to Affective Stimuli in Borderline Personality Disorder: A Randomized Clinical Trial

AU - Paret, Christian

AU - Niedtfeld, Inga

AU - Lotter, Tobias

AU - Wunder, Andreas

AU - Grimm, Simone

AU - Mennes, Maarten

AU - Okell, Thomas

AU - Beckmann, Christian

AU - Schmahl, Christian

N1 - Copyright © 2021 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

PY - 2021/8

Y1 - 2021/8

N2 - BACKGROUND: Psychiatric medication that has a soothing effect on limbic responses to affective stimuli could improve affective instability symptoms as observed in borderline personality disorder (BPD). The objective of this study was to investigate whether citalopram versus placebo reduces the response of the affective neural circuitry during an emotional challenge.METHODS: A total of 30 female individuals with a BPD diagnosis participated in a placebo-controlled, double-blind crossover trial design. Three hours after oral drug intake, individuals with BPD viewed affective pictures while undergoing functional magnetic resonance imaging. Blood oxygen level-dependent responses to images of negative affective scenes and faces showing negative emotional expressions were assessed in regions of interest (amygdala, anterior cingulate cortex, anterior insula, dorsolateral prefrontal cortex). Blood perfusion at rest was assessed with arterial spin labeling.RESULTS: The neural response to pictures showing negative affective scenes was not significantly affected by citalopram (n = 23). Citalopram significantly reduced the amygdala response to pictures of faces with negative affective expressions (n = 25, treatment difference left hemisphere: -0.06 ± 0.16, p < .05; right hemisphere: -0.06 ± 0.17, p < .05). We observed no significant effects of citalopram on the other regions. The drug did not significantly alter blood perfusion at rest.CONCLUSIONS: Citalopram can alter the amygdala response to affective stimuli in BPD, which is characterized by overly responsive affective neural circuitry.

AB - BACKGROUND: Psychiatric medication that has a soothing effect on limbic responses to affective stimuli could improve affective instability symptoms as observed in borderline personality disorder (BPD). The objective of this study was to investigate whether citalopram versus placebo reduces the response of the affective neural circuitry during an emotional challenge.METHODS: A total of 30 female individuals with a BPD diagnosis participated in a placebo-controlled, double-blind crossover trial design. Three hours after oral drug intake, individuals with BPD viewed affective pictures while undergoing functional magnetic resonance imaging. Blood oxygen level-dependent responses to images of negative affective scenes and faces showing negative emotional expressions were assessed in regions of interest (amygdala, anterior cingulate cortex, anterior insula, dorsolateral prefrontal cortex). Blood perfusion at rest was assessed with arterial spin labeling.RESULTS: The neural response to pictures showing negative affective scenes was not significantly affected by citalopram (n = 23). Citalopram significantly reduced the amygdala response to pictures of faces with negative affective expressions (n = 25, treatment difference left hemisphere: -0.06 ± 0.16, p < .05; right hemisphere: -0.06 ± 0.17, p < .05). We observed no significant effects of citalopram on the other regions. The drug did not significantly alter blood perfusion at rest.CONCLUSIONS: Citalopram can alter the amygdala response to affective stimuli in BPD, which is characterized by overly responsive affective neural circuitry.

KW - Amygdala

KW - Borderline Personality Disorder/drug therapy

KW - Citalopram/pharmacology

KW - Emotions

KW - Female

KW - Humans

KW - Magnetic Resonance Imaging

U2 - 10.1016/j.bpsc.2021.02.002

DO - 10.1016/j.bpsc.2021.02.002

M3 - SCORING: Journal article

C2 - 33607327

VL - 6

SP - 837

EP - 845

JO - BIOL PSYCHIAT-COGN N

JF - BIOL PSYCHIAT-COGN N

SN - 2451-9022

IS - 8

ER -