Single-dose Antibiotic Prophylaxis in Regional Anesthesia: A Retrospective Registry Analysis

Hagen Bomberg; Denise Krotten; Christine Kubulus; Stefan Wagenpfeil; Paul Kessler; Thorsten Steinfeldt; Thomas Standl; André Gottschalk; Jan Stork; Winfried Meissner; Juergen Birnbaum; Thea Koch; Daniel I Sessler; Thomas Volk; Alexander Raddatz

doi:10.1097/ALN.0000000000001218

Single-dose Antibiotic Prophylaxis in Regional Anesthesia: A Retrospective Registry Analysis

Standard

Single-dose Antibiotic Prophylaxis in Regional Anesthesia: A Retrospective Registry Analysis. / Bomberg, Hagen; Krotten, Denise; Kubulus, Christine; Wagenpfeil, Stefan; Kessler, Paul; Steinfeldt, Thorsten; Standl, Thomas; Gottschalk, André; Stork, Jan; Meissner, Winfried; Birnbaum, Juergen; Koch, Thea; Sessler, Daniel I; Volk, Thomas; Raddatz, Alexander.

In: ANESTHESIOLOGY, Vol. 125, No. 3, 09.2016, p. 505-15.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Bomberg, H, Krotten, D, Kubulus, C, Wagenpfeil, S, Kessler, P, Steinfeldt, T, Standl, T, Gottschalk, A, Stork, J, Meissner, W, Birnbaum, J, Koch, T, Sessler, DI, Volk, T & Raddatz, A 2016, 'Single-dose Antibiotic Prophylaxis in Regional Anesthesia: A Retrospective Registry Analysis', ANESTHESIOLOGY, vol. 125, no. 3, pp. 505-15. https://doi.org/10.1097/ALN.0000000000001218

APA

Bomberg, H., Krotten, D., Kubulus, C., Wagenpfeil, S., Kessler, P., Steinfeldt, T., Standl, T., Gottschalk, A., Stork, J., Meissner, W., Birnbaum, J., Koch, T., Sessler, D. I., Volk, T., & Raddatz, A. (2016). Single-dose Antibiotic Prophylaxis in Regional Anesthesia: A Retrospective Registry Analysis. ANESTHESIOLOGY, 125(3), 505-15. https://doi.org/10.1097/ALN.0000000000001218

Vancouver

Bomberg H, Krotten D, Kubulus C, Wagenpfeil S, Kessler P, Steinfeldt T et al. Single-dose Antibiotic Prophylaxis in Regional Anesthesia: A Retrospective Registry Analysis. ANESTHESIOLOGY. 2016 Sep;125(3):505-15. https://doi.org/10.1097/ALN.0000000000001218

Bibtex

@article{4affd4ab5d814840bbd5bb827dcbcc02,

title = "Single-dose Antibiotic Prophylaxis in Regional Anesthesia: A Retrospective Registry Analysis",

abstract = "BACKGROUND: Catheter-related infection is a serious complication of continuous regional anesthesia. The authors tested the hypothesis that single-dose antibiotic prophylaxis is associated with a lower incidence of catheter-related infections.METHODS: Our analysis was based on cases in the 25-center German Network for Regional Anesthesia database recorded between 2007 and 2014. Forty thousand three hundred sixty-two surgical patients who had continuous regional anesthesia were grouped into no antibiotic prophylaxis (n = 15,965) and single-dose antibiotic prophylaxis (n = 24,397). Catheter-related infections in each group were compared with chi-square test after 1:1 propensity-score matching. Odds ratios (ORs [95% CI]) were calculated with logistic regression and adjusted for imbalanced variables (standardized difference more than 0.1).RESULTS: Propensity matching successfully paired 11,307 patients with single-dose antibiotic prophylaxis (46% of 24,397 patients) and with 11,307 controls (71% of 15,965 patients). For peripheral catheters, the incidence without antibiotics (2.4%) was greater than with antibiotic prophylaxis (1.1%, P < 0.001; adjusted OR, 2.02; 95% CI, 1.49 to 2.75, P < 0.001). Infections of epidural catheters were also more common without antibiotics (5.2%) than with antibiotics (3.1%, P < 0.001; adjusted OR, 1.94; 95% CI, 1.55 to 2.43, P < 0.001).CONCLUSIONS: Single-dose antibiotic prophylaxis was associated with fewer peripheral and epidural catheter infections.",

keywords = "Journal Article",

author = "Hagen Bomberg and Denise Krotten and Christine Kubulus and Stefan Wagenpfeil and Paul Kessler and Thorsten Steinfeldt and Thomas Standl and Andr{\'e} Gottschalk and Jan Stork and Winfried Meissner and Juergen Birnbaum and Thea Koch and Sessler, {Daniel I} and Thomas Volk and Alexander Raddatz",

year = "2016",

month = sep,

doi = "10.1097/ALN.0000000000001218",

language = "English",

volume = "125",

pages = "505--15",

journal = "ANESTHESIOLOGY",

issn = "0003-3022",

publisher = "Lippincott Williams and Wilkins",

number = "3",

}

RIS

TY - JOUR

T1 - Single-dose Antibiotic Prophylaxis in Regional Anesthesia: A Retrospective Registry Analysis

AU - Bomberg, Hagen

AU - Krotten, Denise

AU - Kubulus, Christine

AU - Wagenpfeil, Stefan

AU - Kessler, Paul

AU - Steinfeldt, Thorsten

AU - Standl, Thomas

AU - Gottschalk, André

AU - Stork, Jan

AU - Meissner, Winfried

AU - Birnbaum, Juergen

AU - Koch, Thea

AU - Sessler, Daniel I

AU - Volk, Thomas

AU - Raddatz, Alexander

PY - 2016/9

Y1 - 2016/9

N2 - BACKGROUND: Catheter-related infection is a serious complication of continuous regional anesthesia. The authors tested the hypothesis that single-dose antibiotic prophylaxis is associated with a lower incidence of catheter-related infections.METHODS: Our analysis was based on cases in the 25-center German Network for Regional Anesthesia database recorded between 2007 and 2014. Forty thousand three hundred sixty-two surgical patients who had continuous regional anesthesia were grouped into no antibiotic prophylaxis (n = 15,965) and single-dose antibiotic prophylaxis (n = 24,397). Catheter-related infections in each group were compared with chi-square test after 1:1 propensity-score matching. Odds ratios (ORs [95% CI]) were calculated with logistic regression and adjusted for imbalanced variables (standardized difference more than 0.1).RESULTS: Propensity matching successfully paired 11,307 patients with single-dose antibiotic prophylaxis (46% of 24,397 patients) and with 11,307 controls (71% of 15,965 patients). For peripheral catheters, the incidence without antibiotics (2.4%) was greater than with antibiotic prophylaxis (1.1%, P < 0.001; adjusted OR, 2.02; 95% CI, 1.49 to 2.75, P < 0.001). Infections of epidural catheters were also more common without antibiotics (5.2%) than with antibiotics (3.1%, P < 0.001; adjusted OR, 1.94; 95% CI, 1.55 to 2.43, P < 0.001).CONCLUSIONS: Single-dose antibiotic prophylaxis was associated with fewer peripheral and epidural catheter infections.

AB - BACKGROUND: Catheter-related infection is a serious complication of continuous regional anesthesia. The authors tested the hypothesis that single-dose antibiotic prophylaxis is associated with a lower incidence of catheter-related infections.METHODS: Our analysis was based on cases in the 25-center German Network for Regional Anesthesia database recorded between 2007 and 2014. Forty thousand three hundred sixty-two surgical patients who had continuous regional anesthesia were grouped into no antibiotic prophylaxis (n = 15,965) and single-dose antibiotic prophylaxis (n = 24,397). Catheter-related infections in each group were compared with chi-square test after 1:1 propensity-score matching. Odds ratios (ORs [95% CI]) were calculated with logistic regression and adjusted for imbalanced variables (standardized difference more than 0.1).RESULTS: Propensity matching successfully paired 11,307 patients with single-dose antibiotic prophylaxis (46% of 24,397 patients) and with 11,307 controls (71% of 15,965 patients). For peripheral catheters, the incidence without antibiotics (2.4%) was greater than with antibiotic prophylaxis (1.1%, P < 0.001; adjusted OR, 2.02; 95% CI, 1.49 to 2.75, P < 0.001). Infections of epidural catheters were also more common without antibiotics (5.2%) than with antibiotics (3.1%, P < 0.001; adjusted OR, 1.94; 95% CI, 1.55 to 2.43, P < 0.001).CONCLUSIONS: Single-dose antibiotic prophylaxis was associated with fewer peripheral and epidural catheter infections.

KW - Journal Article

U2 - 10.1097/ALN.0000000000001218

DO - 10.1097/ALN.0000000000001218

M3 - SCORING: Journal article

C2 - 27384870

VL - 125

SP - 505

EP - 515

JO - ANESTHESIOLOGY

JF - ANESTHESIOLOGY

SN - 0003-3022

IS - 3

ER -