Simultaneous functional MRI acquisition of distributed brain regions with high temporal resolution using a 2D-selective radiofrequency excitation
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Simultaneous functional MRI acquisition of distributed brain regions with high temporal resolution using a 2D-selective radiofrequency excitation. / Finsterbusch, Jürgen.
In: MAGN RESON MED, Vol. 73, No. 2, 02.2015, p. 683-91.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Simultaneous functional MRI acquisition of distributed brain regions with high temporal resolution using a 2D-selective radiofrequency excitation
AU - Finsterbusch, Jürgen
N1 - © 2014 Wiley Periodicals, Inc.
PY - 2015/2
Y1 - 2015/2
N2 - PURPOSE: To perform simultaneous functional MRI of multiple, distributed brain regions at high temporal resolution using a 2D-selective radiofrequency (2DRF) excitation.METHODS: A tailored 2DRF excitation is used to excite several, small regions-of-interest distributed in the brain. They are acquired in a single projection image with an appropriately chosen orientation such that the different regions-of-interest can be discriminated by their position in the projection plane. Thus, they are excited and acquired simultaneously with a temporal resolution comparable to that of a single-slice measurement. The feasibility of this approach for functional neuroimaging (in-plane resolution 2 × 2 mm(2) ) at high temporal resolution (80 ms) is demonstrated in healthy volunteers for regions-of-interest in the visual and motor system using checkerboard and finger tapping block-design paradigms.RESULTS: Task-related brain activation could be observed in both the visual and the motor system simultaneously with a high temporal resolution. For an onset shift of 240 ms for half of the checkerboard, a delay of the hemodynamic response in the corresponding hemisphere of the visual cortex could be detected.CONCLUSION: Limiting the excited magnetization to the desired target regions with a 2DRF excitation reduces the imaging sampling requirements which can improve the temporal resolution significantly.
AB - PURPOSE: To perform simultaneous functional MRI of multiple, distributed brain regions at high temporal resolution using a 2D-selective radiofrequency (2DRF) excitation.METHODS: A tailored 2DRF excitation is used to excite several, small regions-of-interest distributed in the brain. They are acquired in a single projection image with an appropriately chosen orientation such that the different regions-of-interest can be discriminated by their position in the projection plane. Thus, they are excited and acquired simultaneously with a temporal resolution comparable to that of a single-slice measurement. The feasibility of this approach for functional neuroimaging (in-plane resolution 2 × 2 mm(2) ) at high temporal resolution (80 ms) is demonstrated in healthy volunteers for regions-of-interest in the visual and motor system using checkerboard and finger tapping block-design paradigms.RESULTS: Task-related brain activation could be observed in both the visual and the motor system simultaneously with a high temporal resolution. For an onset shift of 240 ms for half of the checkerboard, a delay of the hemodynamic response in the corresponding hemisphere of the visual cortex could be detected.CONCLUSION: Limiting the excited magnetization to the desired target regions with a 2DRF excitation reduces the imaging sampling requirements which can improve the temporal resolution significantly.
KW - Algorithms
KW - Brain
KW - Connectome
KW - Evoked Potentials
KW - Humans
KW - Image Enhancement
KW - Image Interpretation, Computer-Assisted
KW - Magnetic Resonance Imaging
KW - Reproducibility of Results
KW - Sensitivity and Specificity
U2 - 10.1002/mrm.25143
DO - 10.1002/mrm.25143
M3 - SCORING: Journal article
C2 - 24574142
VL - 73
SP - 683
EP - 691
JO - MAGN RESON MED
JF - MAGN RESON MED
SN - 0740-3194
IS - 2
ER -
