Silk proteins in reconstructive surgery: Do they possess an inherent antibacterial activity? A systematic review
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Silk proteins in reconstructive surgery: Do they possess an inherent antibacterial activity? A systematic review. / Schäfer, Sogand; Aavani, Farzaneh; Köpf, Marius; Drinic, Aleksander; Stürmer, Ewa K; Fuest, Sandra; Grust, Audrey Laure Céline; Gosau, Martin; Smeets, Ralf.
In: WOUND REPAIR REGEN, Vol. 31, No. 1, 01.2023, p. 99-110.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Silk proteins in reconstructive surgery: Do they possess an inherent antibacterial activity? A systematic review
AU - Schäfer, Sogand
AU - Aavani, Farzaneh
AU - Köpf, Marius
AU - Drinic, Aleksander
AU - Stürmer, Ewa K
AU - Fuest, Sandra
AU - Grust, Audrey Laure Céline
AU - Gosau, Martin
AU - Smeets, Ralf
N1 - © 2022 The Authors. Wound Repair and Regeneration published by Wiley Periodicals LLC on behalf of The Wound Healing Society.
PY - 2023/1
Y1 - 2023/1
N2 - The field of reconstructive surgery encompasses a wide range of surgical procedures and regenerative approaches to treat various tissue types. Every surgical procedure is associated with the risk of surgical site infections, which are not only a financial burden but also increase patient morbidity. The surgical armamentarium in this area are biomaterials, particularly natural, biodegradable, biocompatible polymers, including the silk proteins fibroin (SF) and sericin (SS). Silk is known to be derived from silkworms and is mainly composed of 60-80% fibroin, which provides the structural form, and 15-35% sericin, which acts as a glue-like substance for the SF threads. Silk proteins possess most of the desired properties for biomedical applications, including biocompatibility, biodegradability, minimal immunogenicity, and tunable biomechanical behaviour. In an effort to alleviate or even prevent infections associated with the use of biomaterials in surgery, antibacterial/antimicrobial properties have been investigated in numerous studies. In this systematic review, the following question was addressed: Do silk proteins, SF and SS, possess an intrinsic antibacterial property and how could these materials be tailored to achieve such a property?
AB - The field of reconstructive surgery encompasses a wide range of surgical procedures and regenerative approaches to treat various tissue types. Every surgical procedure is associated with the risk of surgical site infections, which are not only a financial burden but also increase patient morbidity. The surgical armamentarium in this area are biomaterials, particularly natural, biodegradable, biocompatible polymers, including the silk proteins fibroin (SF) and sericin (SS). Silk is known to be derived from silkworms and is mainly composed of 60-80% fibroin, which provides the structural form, and 15-35% sericin, which acts as a glue-like substance for the SF threads. Silk proteins possess most of the desired properties for biomedical applications, including biocompatibility, biodegradability, minimal immunogenicity, and tunable biomechanical behaviour. In an effort to alleviate or even prevent infections associated with the use of biomaterials in surgery, antibacterial/antimicrobial properties have been investigated in numerous studies. In this systematic review, the following question was addressed: Do silk proteins, SF and SS, possess an intrinsic antibacterial property and how could these materials be tailored to achieve such a property?
KW - Anti-Bacterial Agents/pharmacology
KW - Biocompatible Materials/pharmacology
KW - Fibroins/chemistry
KW - Sericins/pharmacology
KW - Surgery, Plastic
KW - Wound Healing
U2 - 10.1111/wrr.13049
DO - 10.1111/wrr.13049
M3 - SCORING: Review article
C2 - 36106818
VL - 31
SP - 99
EP - 110
JO - WOUND REPAIR REGEN
JF - WOUND REPAIR REGEN
SN - 1067-1927
IS - 1
ER -
