Silicone-based vascular prosthesis: assessment of the mechanical properties
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Silicone-based vascular prosthesis: assessment of the mechanical properties. / Larena-Avellaneda, A; Dittmann, G; Haacke, C; Graunke, F; Siegel, R; Dietz, U A; Debus, E S.
In: ANN VASC SURG, Vol. 22, No. 1, 01.2008, p. 106-114.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Silicone-based vascular prosthesis: assessment of the mechanical properties
AU - Larena-Avellaneda, A
AU - Dittmann, G
AU - Haacke, C
AU - Graunke, F
AU - Siegel, R
AU - Dietz, U A
AU - Debus, E S
PY - 2008/1
Y1 - 2008/1
N2 - We introduce a silicone-based vascular prosthesis that may be optimized in various ways. The current work describes the theoretical background, the fabrication process, and the mechanical properties of these new prostheses, allowing objectification and comparison of materials used in vascular surgery. A production process to coat polyester prostheses with silicone-rubber (polydimethylsiloxane, PDMS) was established. Further modifications (surface improvements, drug incorporation for release) can be performed wet-chemically. Measurement of the physical properties included longitudinal and circumferential stability and elasticity, suture retention strength and puncture resistance (tensile testing machine), permeability, and compliance (circulation model). Prostheses can be multiply coated with PDMS. Sufficiently low levels of permeability (<5 mL/cm(2)/min at 120 mm Hg) were achieved with a PDMS content >15 mg/cm(2). Considering stability, elasticity, and compliance, prostheses with a silicone-rubber content of 15-20 mg/cm(2) are comparable to conventional, primarily tight prostheses. Coating with PDMS decreases suture retention strength and puncture resistance compared to conventional alloplastic materials (collagen-coated polyester and expanded polytetrafluorethylene) materials. The silicone coating surrounds the passing threads ("self-sealing surface") and is resistant to clamping trauma. The complete measurement procedures described here allow for a comparison of new materials with conventional ones and allow the handling characteristics of implants to be objectified. The primarily tight, silicone-coated prostheses can be compared to conventional bovine-coated materials without drawbacks regarding physical properties.
AB - We introduce a silicone-based vascular prosthesis that may be optimized in various ways. The current work describes the theoretical background, the fabrication process, and the mechanical properties of these new prostheses, allowing objectification and comparison of materials used in vascular surgery. A production process to coat polyester prostheses with silicone-rubber (polydimethylsiloxane, PDMS) was established. Further modifications (surface improvements, drug incorporation for release) can be performed wet-chemically. Measurement of the physical properties included longitudinal and circumferential stability and elasticity, suture retention strength and puncture resistance (tensile testing machine), permeability, and compliance (circulation model). Prostheses can be multiply coated with PDMS. Sufficiently low levels of permeability (<5 mL/cm(2)/min at 120 mm Hg) were achieved with a PDMS content >15 mg/cm(2). Considering stability, elasticity, and compliance, prostheses with a silicone-rubber content of 15-20 mg/cm(2) are comparable to conventional, primarily tight prostheses. Coating with PDMS decreases suture retention strength and puncture resistance compared to conventional alloplastic materials (collagen-coated polyester and expanded polytetrafluorethylene) materials. The silicone coating surrounds the passing threads ("self-sealing surface") and is resistant to clamping trauma. The complete measurement procedures described here allow for a comparison of new materials with conventional ones and allow the handling characteristics of implants to be objectified. The primarily tight, silicone-coated prostheses can be compared to conventional bovine-coated materials without drawbacks regarding physical properties.
KW - Animals
KW - Blood Vessel Prosthesis
KW - Collagen/chemistry
KW - Compliance
KW - Dimethylpolysiloxanes/chemistry
KW - Elasticity
KW - Humans
KW - Materials Testing
KW - Microscopy, Electron, Scanning
KW - Permeability
KW - Polyesters/chemistry
KW - Polytetrafluoroethylene/chemistry
KW - Prosthesis Design
KW - Pulsatile Flow
KW - Sheep
KW - Silicones/chemistry
KW - Stress, Mechanical
KW - Tensile Strength
U2 - 10.1016/j.avsg.2007.09.003
DO - 10.1016/j.avsg.2007.09.003
M3 - SCORING: Journal article
C2 - 18083333
VL - 22
SP - 106
EP - 114
JO - ANN VASC SURG
JF - ANN VASC SURG
SN - 0890-5096
IS - 1
ER -
