Research ExplorerPublicationsSilent Brain Infarctions and Leukoaraiosis in Patients With ...

Silent Brain Infarctions and Leukoaraiosis in Patients With Retinal Ischemia: A Prospective Single-Center Observational Study

Standard

Silent Brain Infarctions and Leukoaraiosis in Patients With Retinal Ischemia: A Prospective Single-Center Observational Study. / Golsari, Amir; Bittersohl, Diana; Cheng, Bastian; Griem, Pia; Beck, Christoph; Hassenstein, Andrea; Nedelmann, Max; Magnus, Tim; Fiehler, Jens; Gerloff, Christian; Thomalla, Götz.

In: STROKE, Vol. 48, No. 5, 05.2017, p. 1392-1396.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Golsari, A, Bittersohl, D, Cheng, B, Griem, P, Beck, C, Hassenstein, A, Nedelmann, M, Magnus, T, Fiehler, J, Gerloff, C & Thomalla, G 2017, 'Silent Brain Infarctions and Leukoaraiosis in Patients With Retinal Ischemia: A Prospective Single-Center Observational Study', STROKE, vol. 48, no. 5, pp. 1392-1396. https://doi.org/10.1161/STROKEAHA.117.016467

APA

Golsari, A., Bittersohl, D., Cheng, B., Griem, P., Beck, C., Hassenstein, A., Nedelmann, M., Magnus, T., Fiehler, J., Gerloff, C., & Thomalla, G. (2017). Silent Brain Infarctions and Leukoaraiosis in Patients With Retinal Ischemia: A Prospective Single-Center Observational Study. STROKE, 48(5), 1392-1396. https://doi.org/10.1161/STROKEAHA.117.016467

Vancouver

Golsari A, Bittersohl D, Cheng B, Griem P, Beck C, Hassenstein A et al. Silent Brain Infarctions and Leukoaraiosis in Patients With Retinal Ischemia: A Prospective Single-Center Observational Study. STROKE. 2017 May;48(5):1392-1396. https://doi.org/10.1161/STROKEAHA.117.016467

Bibtex

@article{8e17f0d348144c3d947b82e6123eb743,
title = "Silent Brain Infarctions and Leukoaraiosis in Patients With Retinal Ischemia: A Prospective Single-Center Observational Study",
abstract = "BACKGROUND AND PURPOSE: We aimed to determine the incidence of co-occurring cerebral ischemia, extent of cerebral small vessel disease, and vascular risk profile of patients with acute retinal ischemia.METHODS: RETIS (Frequency of Acute Silent Brain Infarction and Systematic Evaluation of Stroke Risk in Retinal Ischemia) was a single-center, prospective, observational study comprising ophthalmologic examination, brain magnetic resonance imaging, and extensive diagnostic work-up of vascular risk factors and stroke cause. Silent brain infarctions were identified on diffusion-weighted imaging, leukoaraiosis was quantified on fluid-attenuated inversion recovery sequences, and carotid artery stenosis was assessed by carotid ultrasound.RESULTS: Of 112 patients with retinal ischemia, 77 (68.8%) had retinal arterial occlusion, and 35 (31.3%) presented with amaurosis fugax. Silent brain infarctions were found in 17 (15.1%) patients. Internal carotid artery stenosis was present in 19 (17.0%) and severe leukoaraiosis in 29 (25.9%) patients. Atrial fibrillation was detected in 14 (12.5%) patients. Patients with silent brain infarctions had higher rates of internal carotid artery stenosis (35.3% versus 13.7%; P=0.029) than those without, whereas leukoaraiosis and vascular risk factors were comparable between groups. Internal carotid artery stenosis was the only significant predictor of silent brain infarctions in multivariate analysis (odds ratio, 4.27; 95% confidence interval, 1.06-17.23).CONCLUSIONS: Silent cerebral ischemia is present in about 1 in 7 patients with retinal ischemia. The high rate of symptomatic internal carotid artery stenosis suggests that large artery atherosclerosis plays a major role in the pathogenesis of acute retinal ischemia.",
keywords = "Aged, Amaurosis Fugax, Carotid Stenosis, Cerebral Infarction, Comorbidity, Diffusion Magnetic Resonance Imaging, Female, Humans, Incidence, Leukoaraiosis, Magnetic Resonance Imaging, Male, Middle Aged, Retinal Artery Occlusion, Ultrasonography, Journal Article, Observational Study",
author = "Amir Golsari and Diana Bittersohl and Bastian Cheng and Pia Griem and Christoph Beck and Andrea Hassenstein and Max Nedelmann and Tim Magnus and Jens Fiehler and Christian Gerloff and G{\"o}tz Thomalla",
note = "{\textcopyright} 2017 American Heart Association, Inc.",
year = "2017",
month = may,
doi = "10.1161/STROKEAHA.117.016467",
language = "English",
volume = "48",
pages = "1392--1396",
journal = "STROKE",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

RIS

TY - JOUR

T1 - Silent Brain Infarctions and Leukoaraiosis in Patients With Retinal Ischemia: A Prospective Single-Center Observational Study

AU - Golsari, Amir

AU - Bittersohl, Diana

AU - Cheng, Bastian

AU - Griem, Pia

AU - Beck, Christoph

AU - Hassenstein, Andrea

AU - Nedelmann, Max

AU - Magnus, Tim

AU - Fiehler, Jens

AU - Gerloff, Christian

AU - Thomalla, Götz

N1 - © 2017 American Heart Association, Inc.

PY - 2017/5

Y1 - 2017/5

N2 - BACKGROUND AND PURPOSE: We aimed to determine the incidence of co-occurring cerebral ischemia, extent of cerebral small vessel disease, and vascular risk profile of patients with acute retinal ischemia.METHODS: RETIS (Frequency of Acute Silent Brain Infarction and Systematic Evaluation of Stroke Risk in Retinal Ischemia) was a single-center, prospective, observational study comprising ophthalmologic examination, brain magnetic resonance imaging, and extensive diagnostic work-up of vascular risk factors and stroke cause. Silent brain infarctions were identified on diffusion-weighted imaging, leukoaraiosis was quantified on fluid-attenuated inversion recovery sequences, and carotid artery stenosis was assessed by carotid ultrasound.RESULTS: Of 112 patients with retinal ischemia, 77 (68.8%) had retinal arterial occlusion, and 35 (31.3%) presented with amaurosis fugax. Silent brain infarctions were found in 17 (15.1%) patients. Internal carotid artery stenosis was present in 19 (17.0%) and severe leukoaraiosis in 29 (25.9%) patients. Atrial fibrillation was detected in 14 (12.5%) patients. Patients with silent brain infarctions had higher rates of internal carotid artery stenosis (35.3% versus 13.7%; P=0.029) than those without, whereas leukoaraiosis and vascular risk factors were comparable between groups. Internal carotid artery stenosis was the only significant predictor of silent brain infarctions in multivariate analysis (odds ratio, 4.27; 95% confidence interval, 1.06-17.23).CONCLUSIONS: Silent cerebral ischemia is present in about 1 in 7 patients with retinal ischemia. The high rate of symptomatic internal carotid artery stenosis suggests that large artery atherosclerosis plays a major role in the pathogenesis of acute retinal ischemia.

AB - BACKGROUND AND PURPOSE: We aimed to determine the incidence of co-occurring cerebral ischemia, extent of cerebral small vessel disease, and vascular risk profile of patients with acute retinal ischemia.METHODS: RETIS (Frequency of Acute Silent Brain Infarction and Systematic Evaluation of Stroke Risk in Retinal Ischemia) was a single-center, prospective, observational study comprising ophthalmologic examination, brain magnetic resonance imaging, and extensive diagnostic work-up of vascular risk factors and stroke cause. Silent brain infarctions were identified on diffusion-weighted imaging, leukoaraiosis was quantified on fluid-attenuated inversion recovery sequences, and carotid artery stenosis was assessed by carotid ultrasound.RESULTS: Of 112 patients with retinal ischemia, 77 (68.8%) had retinal arterial occlusion, and 35 (31.3%) presented with amaurosis fugax. Silent brain infarctions were found in 17 (15.1%) patients. Internal carotid artery stenosis was present in 19 (17.0%) and severe leukoaraiosis in 29 (25.9%) patients. Atrial fibrillation was detected in 14 (12.5%) patients. Patients with silent brain infarctions had higher rates of internal carotid artery stenosis (35.3% versus 13.7%; P=0.029) than those without, whereas leukoaraiosis and vascular risk factors were comparable between groups. Internal carotid artery stenosis was the only significant predictor of silent brain infarctions in multivariate analysis (odds ratio, 4.27; 95% confidence interval, 1.06-17.23).CONCLUSIONS: Silent cerebral ischemia is present in about 1 in 7 patients with retinal ischemia. The high rate of symptomatic internal carotid artery stenosis suggests that large artery atherosclerosis plays a major role in the pathogenesis of acute retinal ischemia.

KW - Aged

KW - Amaurosis Fugax

KW - Carotid Stenosis

KW - Cerebral Infarction

KW - Comorbidity

KW - Diffusion Magnetic Resonance Imaging

KW - Female

KW - Humans

KW - Incidence

KW - Leukoaraiosis

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Retinal Artery Occlusion

KW - Ultrasonography

KW - Journal Article

KW - Observational Study

U2 - 10.1161/STROKEAHA.117.016467

DO - 10.1161/STROKEAHA.117.016467

M3 - SCORING: Journal article

C2 - 28386036

VL - 48

SP - 1392

EP - 1396

JO - STROKE

JF - STROKE

SN - 0039-2499

IS - 5

ER -