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Short-term esmolol attenuates remodeling of the thoracic aorta in hypertensive rats by decreasing concentrations of ADMA down-regulated by oxidative stress

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Short-term esmolol attenuates remodeling of the thoracic aorta in hypertensive rats by decreasing concentrations of ADMA down-regulated by oxidative stress. / Quintana-Villamandos, Begoña; González, María Carmen; Delgado-Martos, María Jesús; Condezo-Hoyos, Luis; Böger, Rainer H; Lüneburg, Nicole; Pazó-Sayós, Laia; Gutiérrez-Arzapalo, Perla Yareli; Delgado-Baeza, Emilio.

In: EUR J PHARMACOL, Vol. 791, 15.11.2016, p. 502-509.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Quintana-Villamandos, B, González, MC, Delgado-Martos, MJ, Condezo-Hoyos, L, Böger, RH, Lüneburg, N, Pazó-Sayós, L, Gutiérrez-Arzapalo, PY & Delgado-Baeza, E 2016, 'Short-term esmolol attenuates remodeling of the thoracic aorta in hypertensive rats by decreasing concentrations of ADMA down-regulated by oxidative stress', EUR J PHARMACOL, vol. 791, pp. 502-509. https://doi.org/10.1016/j.ejphar.2016.09.020

APA

Quintana-Villamandos, B., González, M. C., Delgado-Martos, M. J., Condezo-Hoyos, L., Böger, R. H., Lüneburg, N., Pazó-Sayós, L., Gutiérrez-Arzapalo, P. Y., & Delgado-Baeza, E. (2016). Short-term esmolol attenuates remodeling of the thoracic aorta in hypertensive rats by decreasing concentrations of ADMA down-regulated by oxidative stress. EUR J PHARMACOL, 791, 502-509. https://doi.org/10.1016/j.ejphar.2016.09.020

Vancouver

Quintana-Villamandos B, González MC, Delgado-Martos MJ, Condezo-Hoyos L, Böger RH, Lüneburg N et al. Short-term esmolol attenuates remodeling of the thoracic aorta in hypertensive rats by decreasing concentrations of ADMA down-regulated by oxidative stress. EUR J PHARMACOL. 2016 Nov 15;791:502-509. https://doi.org/10.1016/j.ejphar.2016.09.020

Bibtex

@article{ef1e3656448943cea4682cd5e4110745,
title = "Short-term esmolol attenuates remodeling of the thoracic aorta in hypertensive rats by decreasing concentrations of ADMA down-regulated by oxidative stress",
abstract = "Esmolol produces early regression of left ventricular hypertrophy and improves coronary artery remodeling, although the impact of short-term treatment with this beta-blocker on remodeling in large arteries has not yet been studied. We hypothesized that even a short (48h) course of esmolol might alter remodeling of the aorta in the spontaneously hypertensive rat (SHR). Fourteen-month-old male SHRs were treated intravenously with vehicle (SHR, n=8) or esmolol (SHR-E, n=8) (300μg/kg/min). Age-matched, vehicle-treated male Wistar-Kyoto rats (WKY, n=8) served as controls. After 48h, we studied the structure, volume density of elastic fibers, and passive mechanical properties of the aorta. Determination of asymmetrical dimethylarginine concentrations and total protein carbonyls in the aorta were analyzed. Esmolol significantly attenuated abnormal aortic wall thickness, cross-sectional area, wall-to-lumen ratio, volume density of elastic fibers, and wall stiffness. The protective effect of esmolol could be related to a decrease in asymmetrical dimethylarginine levels after down-regulation by oxidative stress. These findings could play a key role in the selection of antihypertensive therapy in patients with hypertension and aortic remodeling.",
keywords = "Animals, Aorta, Thoracic/drug effects, Arginine/analogs & derivatives, Blood Pressure/drug effects, Down-Regulation/drug effects, Heart Rate/drug effects, Male, Oxidative Stress/drug effects, Propanolamines/pharmacology, Protein Carbonylation/drug effects, Rats, Rats, Inbred SHR, Tensile Strength/drug effects, Vascular Remodeling/drug effects",
author = "Bego{\~n}a Quintana-Villamandos and Gonz{\'a}lez, {Mar{\'i}a Carmen} and Delgado-Martos, {Mar{\'i}a Jes{\'u}s} and Luis Condezo-Hoyos and B{\"o}ger, {Rainer H} and Nicole L{\"u}neburg and Laia Paz{\'o}-Say{\'o}s and Guti{\'e}rrez-Arzapalo, {Perla Yareli} and Emilio Delgado-Baeza",
note = "Copyright {\textcopyright} 2016 Elsevier B.V. All rights reserved.",
year = "2016",
month = nov,
day = "15",
doi = "10.1016/j.ejphar.2016.09.020",
language = "English",
volume = "791",
pages = "502--509",
journal = "EUR J PHARMACOL",
issn = "0014-2999",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Short-term esmolol attenuates remodeling of the thoracic aorta in hypertensive rats by decreasing concentrations of ADMA down-regulated by oxidative stress

AU - Quintana-Villamandos, Begoña

AU - González, María Carmen

AU - Delgado-Martos, María Jesús

AU - Condezo-Hoyos, Luis

AU - Böger, Rainer H

AU - Lüneburg, Nicole

AU - Pazó-Sayós, Laia

AU - Gutiérrez-Arzapalo, Perla Yareli

AU - Delgado-Baeza, Emilio

N1 - Copyright © 2016 Elsevier B.V. All rights reserved.

PY - 2016/11/15

Y1 - 2016/11/15

N2 - Esmolol produces early regression of left ventricular hypertrophy and improves coronary artery remodeling, although the impact of short-term treatment with this beta-blocker on remodeling in large arteries has not yet been studied. We hypothesized that even a short (48h) course of esmolol might alter remodeling of the aorta in the spontaneously hypertensive rat (SHR). Fourteen-month-old male SHRs were treated intravenously with vehicle (SHR, n=8) or esmolol (SHR-E, n=8) (300μg/kg/min). Age-matched, vehicle-treated male Wistar-Kyoto rats (WKY, n=8) served as controls. After 48h, we studied the structure, volume density of elastic fibers, and passive mechanical properties of the aorta. Determination of asymmetrical dimethylarginine concentrations and total protein carbonyls in the aorta were analyzed. Esmolol significantly attenuated abnormal aortic wall thickness, cross-sectional area, wall-to-lumen ratio, volume density of elastic fibers, and wall stiffness. The protective effect of esmolol could be related to a decrease in asymmetrical dimethylarginine levels after down-regulation by oxidative stress. These findings could play a key role in the selection of antihypertensive therapy in patients with hypertension and aortic remodeling.

AB - Esmolol produces early regression of left ventricular hypertrophy and improves coronary artery remodeling, although the impact of short-term treatment with this beta-blocker on remodeling in large arteries has not yet been studied. We hypothesized that even a short (48h) course of esmolol might alter remodeling of the aorta in the spontaneously hypertensive rat (SHR). Fourteen-month-old male SHRs were treated intravenously with vehicle (SHR, n=8) or esmolol (SHR-E, n=8) (300μg/kg/min). Age-matched, vehicle-treated male Wistar-Kyoto rats (WKY, n=8) served as controls. After 48h, we studied the structure, volume density of elastic fibers, and passive mechanical properties of the aorta. Determination of asymmetrical dimethylarginine concentrations and total protein carbonyls in the aorta were analyzed. Esmolol significantly attenuated abnormal aortic wall thickness, cross-sectional area, wall-to-lumen ratio, volume density of elastic fibers, and wall stiffness. The protective effect of esmolol could be related to a decrease in asymmetrical dimethylarginine levels after down-regulation by oxidative stress. These findings could play a key role in the selection of antihypertensive therapy in patients with hypertension and aortic remodeling.

KW - Animals

KW - Aorta, Thoracic/drug effects

KW - Arginine/analogs & derivatives

KW - Blood Pressure/drug effects

KW - Down-Regulation/drug effects

KW - Heart Rate/drug effects

KW - Male

KW - Oxidative Stress/drug effects

KW - Propanolamines/pharmacology

KW - Protein Carbonylation/drug effects

KW - Rats

KW - Rats, Inbred SHR

KW - Tensile Strength/drug effects

KW - Vascular Remodeling/drug effects

U2 - 10.1016/j.ejphar.2016.09.020

DO - 10.1016/j.ejphar.2016.09.020

M3 - SCORING: Journal article

C2 - 27639298

VL - 791

SP - 502

EP - 509

JO - EUR J PHARMACOL

JF - EUR J PHARMACOL

SN - 0014-2999

ER -