Short tandem repeat polymorphism in exon 4 of esophageal cancer related gene 2 predicts relapse of oral squamous cell carcinoma.
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Short tandem repeat polymorphism in exon 4 of esophageal cancer related gene 2 predicts relapse of oral squamous cell carcinoma. / Blessmann, Marco; Kaifi, Jussuf; Schurr, Paulus; Cihan, Asli; Kalinin, Viacheslav; Trump, Florian; Atac, Artun; Heiland, Max; Pohlenz, Philipp; Blake, Felix; Schmelzle, Rainer; Izbicki, Jakob R.
In: ORAL ONCOL, Vol. 44, No. 2, 2, 2008, p. 143-147.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Short tandem repeat polymorphism in exon 4 of esophageal cancer related gene 2 predicts relapse of oral squamous cell carcinoma.
AU - Blessmann, Marco
AU - Kaifi, Jussuf
AU - Schurr, Paulus
AU - Cihan, Asli
AU - Kalinin, Viacheslav
AU - Trump, Florian
AU - Atac, Artun
AU - Heiland, Max
AU - Pohlenz, Philipp
AU - Blake, Felix
AU - Schmelzle, Rainer
AU - Izbicki, Jakob R.
PY - 2008
Y1 - 2008
N2 - Short tandem repeat (STR) polymorphisms in exon 4 of esophageal cancer related gene 2 (ECRG2) are a prognostic marker for squamous cell carcinoma (SCC) of the esophagus. The aim of the present study was to correlate these STRs with clinical outcome of the similar tumor type oral squamous cell carcinoma (OSCC). DNA of 81 patients that underwent complete surgical resection of OSCC was analyzed for STRs TCA3/TCA3, TCA3/TCA4 and TCA4/TCA4 in exon 4 of ECRG2 by PCR, capillary electrophoresis and DNA sequencing. ECRG2 STR TCA3/TCA3 were found in 45 (56%), TCA3/TCA4 in 33 (41%) and TCA4/TCA4 in 3 (3%) patients. TCA3/TCA3 was significantly associated with reduced relapse-free survival of OSCC, compared with TCA3/TCA4 and TCA4/TCA4 genotypes (P
AB - Short tandem repeat (STR) polymorphisms in exon 4 of esophageal cancer related gene 2 (ECRG2) are a prognostic marker for squamous cell carcinoma (SCC) of the esophagus. The aim of the present study was to correlate these STRs with clinical outcome of the similar tumor type oral squamous cell carcinoma (OSCC). DNA of 81 patients that underwent complete surgical resection of OSCC was analyzed for STRs TCA3/TCA3, TCA3/TCA4 and TCA4/TCA4 in exon 4 of ECRG2 by PCR, capillary electrophoresis and DNA sequencing. ECRG2 STR TCA3/TCA3 were found in 45 (56%), TCA3/TCA4 in 33 (41%) and TCA4/TCA4 in 3 (3%) patients. TCA3/TCA3 was significantly associated with reduced relapse-free survival of OSCC, compared with TCA3/TCA4 and TCA4/TCA4 genotypes (P
M3 - SCORING: Zeitschriftenaufsatz
VL - 44
SP - 143
EP - 147
JO - ORAL ONCOL
JF - ORAL ONCOL
SN - 1368-8375
IS - 2
M1 - 2
ER -