Shifting of cortical somatosensory areas in a man with amelia
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Shifting of cortical somatosensory areas in a man with amelia. / Kamping, Sandra; Lütkenhöner, Bernd; Knecht, Stefan.
In: NEUROREPORT, Vol. 15, No. 15, 25.10.2004, p. 2365-8.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Shifting of cortical somatosensory areas in a man with amelia
AU - Kamping, Sandra
AU - Lütkenhöner, Bernd
AU - Knecht, Stefan
PY - 2004/10/25
Y1 - 2004/10/25
N2 - The human brain represents the body in a homuncular fashion. Although these cortical representations are to some degree plastic, it is unclear how extensive this plasticity can be. Examinations of amputated or amelic subjects can contribute to answering this question. We examined a man who lacked both arms since birth and was free of phantom pain. Magnetic source imaging revealed that not only had the somatotopically adjacent representation of the lip moved into the cortical space usually representing the hand; but the representation of the foot had similarly moved towards the cortical hand area. These data illustrate a case of extensive cortical reorganization and suggest that the potential overlap of different body parts is much greater than previously anticipated.
AB - The human brain represents the body in a homuncular fashion. Although these cortical representations are to some degree plastic, it is unclear how extensive this plasticity can be. Examinations of amputated or amelic subjects can contribute to answering this question. We examined a man who lacked both arms since birth and was free of phantom pain. Magnetic source imaging revealed that not only had the somatotopically adjacent representation of the lip moved into the cortical space usually representing the hand; but the representation of the foot had similarly moved towards the cortical hand area. These data illustrate a case of extensive cortical reorganization and suggest that the potential overlap of different body parts is much greater than previously anticipated.
KW - Adult
KW - Analysis of Variance
KW - Brain Mapping
KW - Confidence Intervals
KW - Ectromelia
KW - Electric Stimulation
KW - Evoked Potentials, Somatosensory
KW - Foot
KW - Functional Laterality
KW - Humans
KW - Lip
KW - Magnetoencephalography
KW - Male
KW - Neuronal Plasticity
KW - Somatosensory Cortex
M3 - SCORING: Journal article
C2 - 15640757
VL - 15
SP - 2365
EP - 2368
JO - NEUROREPORT
JF - NEUROREPORT
SN - 0959-4965
IS - 15
ER -