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Shared and distinct white matter abnormalities in adolescent-onset schizophrenia and adolescent-onset psychotic bipolar disorder

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Shared and distinct white matter abnormalities in adolescent-onset schizophrenia and adolescent-onset psychotic bipolar disorder. / Seitz-Holland, Johanna; Nägele, Felix; Kubicki, Marek; Pasternak, Ofer; Cho, Kang Ik K.; Hough, Morgan; Mulert, Christoph; Shenton, Martha E; Crow, Timothy J. ; Anthony, James C; Lyall, Amanda.

In: PSYCHOL MED, Vol. 53, No. 10, 07.2023, p. 4707-4719.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Seitz-Holland, J, Nägele, F, Kubicki, M, Pasternak, O, Cho, KIK, Hough, M, Mulert, C, Shenton, ME, Crow, TJ, Anthony, JC & Lyall, A 2023, 'Shared and distinct white matter abnormalities in adolescent-onset schizophrenia and adolescent-onset psychotic bipolar disorder', PSYCHOL MED, vol. 53, no. 10, pp. 4707-4719. https://doi.org/10.1017/S003329172200160X

APA

Seitz-Holland, J., Nägele, F., Kubicki, M., Pasternak, O., Cho, K. I. K., Hough, M., Mulert, C., Shenton, M. E., Crow, T. J., Anthony, J. C., & Lyall, A. (2023). Shared and distinct white matter abnormalities in adolescent-onset schizophrenia and adolescent-onset psychotic bipolar disorder. PSYCHOL MED, 53(10), 4707-4719. https://doi.org/10.1017/S003329172200160X

Vancouver

Seitz-Holland J, Nägele F, Kubicki M, Pasternak O, Cho KIK, Hough M et al. Shared and distinct white matter abnormalities in adolescent-onset schizophrenia and adolescent-onset psychotic bipolar disorder. PSYCHOL MED. 2023 Jul;53(10):4707-4719. https://doi.org/10.1017/S003329172200160X

Bibtex

@article{2064d314f11947298da5d988e2ec23d2,
title = "Shared and distinct white matter abnormalities in adolescent-onset schizophrenia and adolescent-onset psychotic bipolar disorder",
abstract = "BACKGROUND: While adolescent-onset schizophrenia (ADO-SCZ) and adolescent-onset bipolar disorder with psychosis (psychotic ADO-BPD) present a more severe clinical course than their adult forms, their pathophysiology is poorly understood. Here, we study potentially state- and trait-related white matter diffusion-weighted magnetic resonance imaging (dMRI) abnormalities along the adolescent-onset psychosis continuum to address this need.METHODS: Forty-eight individuals with ADO-SCZ (20 female/28 male), 15 individuals with psychotic ADO-BPD (7 female/8 male), and 35 healthy controls (HCs, 18 female/17 male) underwent dMRI and clinical assessments. Maps of extracellular free-water (FW) and fractional anisotropy of cellular tissue (FAT) were compared between individuals with psychosis and HCs using tract-based spatial statistics and FSL's Randomise. FAT and FW values were extracted, averaged across all voxels that demonstrated group differences, and then utilized to test for the influence of age, medication, age of onset, duration of illness, symptom severity, and intelligence.RESULTS: Individuals with adolescent-onset psychosis exhibited pronounced FW and FAT abnormalities compared to HCs. FAT reductions were spatially more widespread in ADO-SCZ. FW increases, however, were only present in psychotic ADO-BPD. In HCs, but not in individuals with adolescent-onset psychosis, FAT was positively related to age.CONCLUSIONS: We observe evidence for cellular (FAT) and extracellular (FW) white matter abnormalities in adolescent-onset psychosis. Although cellular white matter abnormalities were more prominent in ADO-SCZ, such alterations may reflect a shared trait, i.e. neurodevelopmental pathology, present across the psychosis spectrum. Extracellular abnormalities were evident in psychotic ADO-BPD, potentially indicating a more dynamic, state-dependent brain reaction to psychosis.",
author = "Johanna Seitz-Holland and Felix N{\"a}gele and Marek Kubicki and Ofer Pasternak and Cho, {Kang Ik K.} and Morgan Hough and Christoph Mulert and Shenton, {Martha E} and Crow, {Timothy J.} and Anthony, {James C} and Amanda Lyall",
year = "2023",
month = jul,
doi = "10.1017/S003329172200160X",
language = "English",
volume = "53",
pages = "4707--4719",
journal = "PSYCHOL MED",
issn = "0033-2917",
publisher = "Cambridge University Press",
number = "10",

}

RIS

TY - JOUR

T1 - Shared and distinct white matter abnormalities in adolescent-onset schizophrenia and adolescent-onset psychotic bipolar disorder

AU - Seitz-Holland, Johanna

AU - Nägele, Felix

AU - Kubicki, Marek

AU - Pasternak, Ofer

AU - Cho, Kang Ik K.

AU - Hough, Morgan

AU - Mulert, Christoph

AU - Shenton, Martha E

AU - Crow, Timothy J.

AU - Anthony, James C

AU - Lyall, Amanda

PY - 2023/7

Y1 - 2023/7

N2 - BACKGROUND: While adolescent-onset schizophrenia (ADO-SCZ) and adolescent-onset bipolar disorder with psychosis (psychotic ADO-BPD) present a more severe clinical course than their adult forms, their pathophysiology is poorly understood. Here, we study potentially state- and trait-related white matter diffusion-weighted magnetic resonance imaging (dMRI) abnormalities along the adolescent-onset psychosis continuum to address this need.METHODS: Forty-eight individuals with ADO-SCZ (20 female/28 male), 15 individuals with psychotic ADO-BPD (7 female/8 male), and 35 healthy controls (HCs, 18 female/17 male) underwent dMRI and clinical assessments. Maps of extracellular free-water (FW) and fractional anisotropy of cellular tissue (FAT) were compared between individuals with psychosis and HCs using tract-based spatial statistics and FSL's Randomise. FAT and FW values were extracted, averaged across all voxels that demonstrated group differences, and then utilized to test for the influence of age, medication, age of onset, duration of illness, symptom severity, and intelligence.RESULTS: Individuals with adolescent-onset psychosis exhibited pronounced FW and FAT abnormalities compared to HCs. FAT reductions were spatially more widespread in ADO-SCZ. FW increases, however, were only present in psychotic ADO-BPD. In HCs, but not in individuals with adolescent-onset psychosis, FAT was positively related to age.CONCLUSIONS: We observe evidence for cellular (FAT) and extracellular (FW) white matter abnormalities in adolescent-onset psychosis. Although cellular white matter abnormalities were more prominent in ADO-SCZ, such alterations may reflect a shared trait, i.e. neurodevelopmental pathology, present across the psychosis spectrum. Extracellular abnormalities were evident in psychotic ADO-BPD, potentially indicating a more dynamic, state-dependent brain reaction to psychosis.

AB - BACKGROUND: While adolescent-onset schizophrenia (ADO-SCZ) and adolescent-onset bipolar disorder with psychosis (psychotic ADO-BPD) present a more severe clinical course than their adult forms, their pathophysiology is poorly understood. Here, we study potentially state- and trait-related white matter diffusion-weighted magnetic resonance imaging (dMRI) abnormalities along the adolescent-onset psychosis continuum to address this need.METHODS: Forty-eight individuals with ADO-SCZ (20 female/28 male), 15 individuals with psychotic ADO-BPD (7 female/8 male), and 35 healthy controls (HCs, 18 female/17 male) underwent dMRI and clinical assessments. Maps of extracellular free-water (FW) and fractional anisotropy of cellular tissue (FAT) were compared between individuals with psychosis and HCs using tract-based spatial statistics and FSL's Randomise. FAT and FW values were extracted, averaged across all voxels that demonstrated group differences, and then utilized to test for the influence of age, medication, age of onset, duration of illness, symptom severity, and intelligence.RESULTS: Individuals with adolescent-onset psychosis exhibited pronounced FW and FAT abnormalities compared to HCs. FAT reductions were spatially more widespread in ADO-SCZ. FW increases, however, were only present in psychotic ADO-BPD. In HCs, but not in individuals with adolescent-onset psychosis, FAT was positively related to age.CONCLUSIONS: We observe evidence for cellular (FAT) and extracellular (FW) white matter abnormalities in adolescent-onset psychosis. Although cellular white matter abnormalities were more prominent in ADO-SCZ, such alterations may reflect a shared trait, i.e. neurodevelopmental pathology, present across the psychosis spectrum. Extracellular abnormalities were evident in psychotic ADO-BPD, potentially indicating a more dynamic, state-dependent brain reaction to psychosis.

U2 - 10.1017/S003329172200160X

DO - 10.1017/S003329172200160X

M3 - SCORING: Journal article

VL - 53

SP - 4707

EP - 4719

JO - PSYCHOL MED

JF - PSYCHOL MED

SN - 0033-2917

IS - 10

ER -