SGLT2 Inhibitors and Peripheral Vascular Events: A Review of the Literature

  • Elena Marchiori
  • Roman N Rodionov
  • Frederik Peters
  • Christina Magnussen
  • Joakim Nordanstig
  • Alexander Gombert
  • Konstantinos Spanos
  • Natalia Jarzebska
  • Christian-Alexander Behrendt

Abstract

Fifty articles comprising 18 randomized controlled trials (RCTs), 16 observational studies, and 16 meta-analyses on the safety and effectiveness of sodium-glucose cotransporter 2 inhibitors were evaluated in the current review. Only one-fourth of the cohorts of recent trials had peripheral arterial disease (PAD), whereas this subgroup was at high risk for amputations. Despite a remarkable heterogeneity of RCTs, only 2 trials on canagliflozin suggested excess amputation rates, whereas several observational studies generated conflicting conclusions and remained short on possible explanations. Preliminary evidence from observational research suggested that patients with PAD may even benefit from SGLT-2 inhibitor treatment due to lower observed heart failure hospitalization rates.

Bibliographical data

Original languageEnglish
ISSN1551-7136
DOIs
Publication statusPublished - 10.2022

Comment Deanary

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PubMed 36216490