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Sex-specific lesion pattern of functional outcomes after stroke

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Sex-specific lesion pattern of functional outcomes after stroke. / Bonkhoff, Anna K; Bretzner, Martin; Hong, Sungmin; Schirmer, Markus D; Cohen, Alexander; Regenhardt, Robert W; Donahue, Kathleen L; Nardin, Marco J; Dalca, Adrian V; Giese, Anne-Katrin; Etherton, Mark R; Hancock, Brandon L; Mocking, Steven J T; McIntosh, Elissa C; Attia, John; Benavente, Oscar R; Bevan, Stephen; Cole, John W; Donatti, Amanda; Griessenauer, Christoph J; Heitsch, Laura; Holmegaard, Lukas; Jood, Katarina; Jimenez-Conde, Jordi; Kittner, Steven J; Lemmens, Robin; Levi, Christopher R; McDonough, Caitrin W; Meschia, James F; Phuah, Chia-Ling; Rolfs, Arndt; Ropele, Stefan; Rosand, Jonathan; Roquer, Jaume; Rundek, Tatjana; Sacco, Ralph L; Schmidt, Reinhold; Sharma, Pankaj; Slowik, Agnieszka; Söderholm, Martin; Sousa, Alessandro; Stanne, Tara M; Strbian, Daniel; Tatlisumak, Turgut; Thijs, Vincent; Vagal, Achala; Wasselius, Johan; Woo, Daniel; Zand, Ramin; McArdle, Patrick F; Worrall, Bradford B; Jern, Christina; Lindgren, Arne G; Maguire, Jane; Fox, Michael D; Bzdok, Danilo; Wu, Ona; Rost, Natalia S; MRI-GENIE and GISCOME Investigators and the International Stroke Genetics Consortium.

In: BRAIN COMMUN, Vol. 4, No. 2, fcac020, 2022.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Bonkhoff, AK, Bretzner, M, Hong, S, Schirmer, MD, Cohen, A, Regenhardt, RW, Donahue, KL, Nardin, MJ, Dalca, AV, Giese, A-K, Etherton, MR, Hancock, BL, Mocking, SJT, McIntosh, EC, Attia, J, Benavente, OR, Bevan, S, Cole, JW, Donatti, A, Griessenauer, CJ, Heitsch, L, Holmegaard, L, Jood, K, Jimenez-Conde, J, Kittner, SJ, Lemmens, R, Levi, CR, McDonough, CW, Meschia, JF, Phuah, C-L, Rolfs, A, Ropele, S, Rosand, J, Roquer, J, Rundek, T, Sacco, RL, Schmidt, R, Sharma, P, Slowik, A, Söderholm, M, Sousa, A, Stanne, TM, Strbian, D, Tatlisumak, T, Thijs, V, Vagal, A, Wasselius, J, Woo, D, Zand, R, McArdle, PF, Worrall, BB, Jern, C, Lindgren, AG, Maguire, J, Fox, MD, Bzdok, D, Wu, O, Rost, NS & MRI-GENIE and GISCOME Investigators and the International Stroke Genetics Consortium 2022, 'Sex-specific lesion pattern of functional outcomes after stroke', BRAIN COMMUN, vol. 4, no. 2, fcac020. https://doi.org/10.1093/braincomms/fcac020

APA

Bonkhoff, A. K., Bretzner, M., Hong, S., Schirmer, M. D., Cohen, A., Regenhardt, R. W., Donahue, K. L., Nardin, M. J., Dalca, A. V., Giese, A-K., Etherton, M. R., Hancock, B. L., Mocking, S. J. T., McIntosh, E. C., Attia, J., Benavente, O. R., Bevan, S., Cole, J. W., Donatti, A., ... MRI-GENIE and GISCOME Investigators and the International Stroke Genetics Consortium (2022). Sex-specific lesion pattern of functional outcomes after stroke. BRAIN COMMUN, 4(2), [fcac020]. https://doi.org/10.1093/braincomms/fcac020

Vancouver

Bonkhoff AK, Bretzner M, Hong S, Schirmer MD, Cohen A, Regenhardt RW et al. Sex-specific lesion pattern of functional outcomes after stroke. BRAIN COMMUN. 2022;4(2). fcac020. https://doi.org/10.1093/braincomms/fcac020

Bibtex

@article{a1272208067b43549d93a913ff1bafc2,
title = "Sex-specific lesion pattern of functional outcomes after stroke",
abstract = "Stroke represents a considerable burden of disease for both men and women. However, a growing body of literature suggests clinically relevant sex differences in the underlying causes, presentations and outcomes of acute ischaemic stroke. In a recent study, we reported sex divergences in lesion topographies: specific to women, acute stroke severity was linked to lesions in the left-hemispheric posterior circulation. We here determined whether these sex-specific brain manifestations also affect long-term outcomes. We relied on 822 acute ischaemic patients [age: 64.7 (15.0) years, 39% women] originating from the multi-centre MRI-GENIE study to model unfavourable outcomes (modified Rankin Scale >2) based on acute neuroimaging data in a Bayesian hierarchical framework. Lesions encompassing bilateral subcortical nuclei and left-lateralized regions in proximity to the insula explained outcomes across men and women (area under the curve = 0.81). A pattern of left-hemispheric posterior circulation brain regions, combining left hippocampus, precuneus, fusiform and lingual gyrus, occipital pole and latero-occipital cortex, showed a substantially higher relevance in explaining functional outcomes in women compared to men [mean difference of Bayesian posterior distributions (men - women) = -0.295 (90% highest posterior density interval = -0.556 to -0.068)]. Once validated in prospective studies, our findings may motivate a sex-specific approach to clinical stroke management and hold the promise of enhancing outcomes on a population level.",
author = "Bonkhoff, {Anna K} and Martin Bretzner and Sungmin Hong and Schirmer, {Markus D} and Alexander Cohen and Regenhardt, {Robert W} and Donahue, {Kathleen L} and Nardin, {Marco J} and Dalca, {Adrian V} and Anne-Katrin Giese and Etherton, {Mark R} and Hancock, {Brandon L} and Mocking, {Steven J T} and McIntosh, {Elissa C} and John Attia and Benavente, {Oscar R} and Stephen Bevan and Cole, {John W} and Amanda Donatti and Griessenauer, {Christoph J} and Laura Heitsch and Lukas Holmegaard and Katarina Jood and Jordi Jimenez-Conde and Kittner, {Steven J} and Robin Lemmens and Levi, {Christopher R} and McDonough, {Caitrin W} and Meschia, {James F} and Chia-Ling Phuah and Arndt Rolfs and Stefan Ropele and Jonathan Rosand and Jaume Roquer and Tatjana Rundek and Sacco, {Ralph L} and Reinhold Schmidt and Pankaj Sharma and Agnieszka Slowik and Martin S{\"o}derholm and Alessandro Sousa and Stanne, {Tara M} and Daniel Strbian and Turgut Tatlisumak and Vincent Thijs and Achala Vagal and Johan Wasselius and Daniel Woo and Ramin Zand and McArdle, {Patrick F} and Worrall, {Bradford B} and Christina Jern and Lindgren, {Arne G} and Jane Maguire and Fox, {Michael D} and Danilo Bzdok and Ona Wu and Rost, {Natalia S} and {MRI-GENIE and GISCOME Investigators and the International Stroke Genetics Consortium}",
note = "{\textcopyright} The Author(s) 2022. Published by Oxford University Press on behalf of the Guarantors of Brain.",
year = "2022",
doi = "10.1093/braincomms/fcac020",
language = "English",
volume = "4",
journal = "BRAIN COMMUN",
issn = "2632-1297",
publisher = "OXFORD UNIV PRESS",
number = "2",

}

RIS

TY - JOUR

T1 - Sex-specific lesion pattern of functional outcomes after stroke

AU - Bonkhoff, Anna K

AU - Bretzner, Martin

AU - Hong, Sungmin

AU - Schirmer, Markus D

AU - Cohen, Alexander

AU - Regenhardt, Robert W

AU - Donahue, Kathleen L

AU - Nardin, Marco J

AU - Dalca, Adrian V

AU - Giese, Anne-Katrin

AU - Etherton, Mark R

AU - Hancock, Brandon L

AU - Mocking, Steven J T

AU - McIntosh, Elissa C

AU - Attia, John

AU - Benavente, Oscar R

AU - Bevan, Stephen

AU - Cole, John W

AU - Donatti, Amanda

AU - Griessenauer, Christoph J

AU - Heitsch, Laura

AU - Holmegaard, Lukas

AU - Jood, Katarina

AU - Jimenez-Conde, Jordi

AU - Kittner, Steven J

AU - Lemmens, Robin

AU - Levi, Christopher R

AU - McDonough, Caitrin W

AU - Meschia, James F

AU - Phuah, Chia-Ling

AU - Rolfs, Arndt

AU - Ropele, Stefan

AU - Rosand, Jonathan

AU - Roquer, Jaume

AU - Rundek, Tatjana

AU - Sacco, Ralph L

AU - Schmidt, Reinhold

AU - Sharma, Pankaj

AU - Slowik, Agnieszka

AU - Söderholm, Martin

AU - Sousa, Alessandro

AU - Stanne, Tara M

AU - Strbian, Daniel

AU - Tatlisumak, Turgut

AU - Thijs, Vincent

AU - Vagal, Achala

AU - Wasselius, Johan

AU - Woo, Daniel

AU - Zand, Ramin

AU - McArdle, Patrick F

AU - Worrall, Bradford B

AU - Jern, Christina

AU - Lindgren, Arne G

AU - Maguire, Jane

AU - Fox, Michael D

AU - Bzdok, Danilo

AU - Wu, Ona

AU - Rost, Natalia S

AU - MRI-GENIE and GISCOME Investigators and the International Stroke Genetics Consortium

N1 - © The Author(s) 2022. Published by Oxford University Press on behalf of the Guarantors of Brain.

PY - 2022

Y1 - 2022

N2 - Stroke represents a considerable burden of disease for both men and women. However, a growing body of literature suggests clinically relevant sex differences in the underlying causes, presentations and outcomes of acute ischaemic stroke. In a recent study, we reported sex divergences in lesion topographies: specific to women, acute stroke severity was linked to lesions in the left-hemispheric posterior circulation. We here determined whether these sex-specific brain manifestations also affect long-term outcomes. We relied on 822 acute ischaemic patients [age: 64.7 (15.0) years, 39% women] originating from the multi-centre MRI-GENIE study to model unfavourable outcomes (modified Rankin Scale >2) based on acute neuroimaging data in a Bayesian hierarchical framework. Lesions encompassing bilateral subcortical nuclei and left-lateralized regions in proximity to the insula explained outcomes across men and women (area under the curve = 0.81). A pattern of left-hemispheric posterior circulation brain regions, combining left hippocampus, precuneus, fusiform and lingual gyrus, occipital pole and latero-occipital cortex, showed a substantially higher relevance in explaining functional outcomes in women compared to men [mean difference of Bayesian posterior distributions (men - women) = -0.295 (90% highest posterior density interval = -0.556 to -0.068)]. Once validated in prospective studies, our findings may motivate a sex-specific approach to clinical stroke management and hold the promise of enhancing outcomes on a population level.

AB - Stroke represents a considerable burden of disease for both men and women. However, a growing body of literature suggests clinically relevant sex differences in the underlying causes, presentations and outcomes of acute ischaemic stroke. In a recent study, we reported sex divergences in lesion topographies: specific to women, acute stroke severity was linked to lesions in the left-hemispheric posterior circulation. We here determined whether these sex-specific brain manifestations also affect long-term outcomes. We relied on 822 acute ischaemic patients [age: 64.7 (15.0) years, 39% women] originating from the multi-centre MRI-GENIE study to model unfavourable outcomes (modified Rankin Scale >2) based on acute neuroimaging data in a Bayesian hierarchical framework. Lesions encompassing bilateral subcortical nuclei and left-lateralized regions in proximity to the insula explained outcomes across men and women (area under the curve = 0.81). A pattern of left-hemispheric posterior circulation brain regions, combining left hippocampus, precuneus, fusiform and lingual gyrus, occipital pole and latero-occipital cortex, showed a substantially higher relevance in explaining functional outcomes in women compared to men [mean difference of Bayesian posterior distributions (men - women) = -0.295 (90% highest posterior density interval = -0.556 to -0.068)]. Once validated in prospective studies, our findings may motivate a sex-specific approach to clinical stroke management and hold the promise of enhancing outcomes on a population level.

U2 - 10.1093/braincomms/fcac020

DO - 10.1093/braincomms/fcac020

M3 - SCORING: Journal article

C2 - 35282166

VL - 4

JO - BRAIN COMMUN

JF - BRAIN COMMUN

SN - 2632-1297

IS - 2

M1 - fcac020

ER -