Sex-related outcome of atrial fibrillation ablation: Insights from the German Ablation Registry

Maura M Zylla; Johannes Brachmann; Thorsten Lewalter; Ellen Hoffmann; Karl-Heinz Kuck; Dietrich Andresen; Stephan Willems; Lars Eckardt; Jürgen Tebbenjohanns; Stefan G Spitzer; Burghard Schumacher; Matthias Hochadel; Jochen Senges; Hugo A Katus; Dierk Thomas

doi:10.1016/j.hrthm.2016.06.005

Sex-related outcome of atrial fibrillation ablation: Insights from the German Ablation Registry

Standard

Sex-related outcome of atrial fibrillation ablation: Insights from the German Ablation Registry. / Zylla, Maura M; Brachmann, Johannes; Lewalter, Thorsten; Hoffmann, Ellen; Kuck, Karl-Heinz; Andresen, Dietrich; Willems, Stephan; Eckardt, Lars; Tebbenjohanns, Jürgen; Spitzer, Stefan G; Schumacher, Burghard; Hochadel, Matthias; Senges, Jochen; Katus, Hugo A; Thomas, Dierk.

In: HEART RHYTHM, Vol. 13, No. 9, 09.2016, p. 1837-44.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Zylla, MM, Brachmann, J, Lewalter, T, Hoffmann, E, Kuck, K-H, Andresen, D, Willems, S, Eckardt, L, Tebbenjohanns, J, Spitzer, SG, Schumacher, B, Hochadel, M, Senges, J, Katus, HA & Thomas, D 2016, 'Sex-related outcome of atrial fibrillation ablation: Insights from the German Ablation Registry', HEART RHYTHM, vol. 13, no. 9, pp. 1837-44. https://doi.org/10.1016/j.hrthm.2016.06.005

APA

Zylla, M. M., Brachmann, J., Lewalter, T., Hoffmann, E., Kuck, K-H., Andresen, D., Willems, S., Eckardt, L., Tebbenjohanns, J., Spitzer, S. G., Schumacher, B., Hochadel, M., Senges, J., Katus, H. A., & Thomas, D. (2016). Sex-related outcome of atrial fibrillation ablation: Insights from the German Ablation Registry. HEART RHYTHM, 13(9), 1837-44. https://doi.org/10.1016/j.hrthm.2016.06.005

Vancouver

Zylla MM, Brachmann J, Lewalter T, Hoffmann E, Kuck K-H, Andresen D et al. Sex-related outcome of atrial fibrillation ablation: Insights from the German Ablation Registry. HEART RHYTHM. 2016 Sep;13(9):1837-44. https://doi.org/10.1016/j.hrthm.2016.06.005

Bibtex

@article{a3910c6df67b40cea1f3f1b282b3e8bd,

title = "Sex-related outcome of atrial fibrillation ablation: Insights from the German Ablation Registry",

abstract = "BACKGROUND: Stratification of patients with atrial fibrillation (AF) according to mechanistic and prognostic criteria may optimize the effectiveness and safety of catheter ablation. In women, AF is associated with more severe symptoms and worse prognosis.OBJECTIVE: We sought to assess sex-related differences in catheter ablation procedures and outcome in a large cohort of patients with AF.METHODS: A total of 3652 patients (1198 women [33%]; 2454 men [67%]) included in the German Ablation Registry were analyzed. Periprocedural parameters and outcome at 12-month follow-up were compared between male and female patients.RESULTS: Women were older at the time of ablation (women: 63.6 years; men: 59.1 years; P < .0001) and exhibited a higher prevalence of paroxysmal AF (women: 72%; men: 61%; P < .0001). They were less often affected by cardiovascular disease and reduced left ventricular function. Energy application duration and overall procedure duration were shorter in women. Conversely, the rate of major inhospital complications was increased in female patients (1.9% vs 0.8%; P = .023) and mainly driven by major bleeding events. At follow-up, women experienced higher AF recurrence rates (women: 50%; men: 45%; P = .017) and more often received oral medication for rhythm and rate control. In addition, the rate of pacemaker implantation was higher in the female cohort. Women more frequently reported femoral access site complications (women: 6%; men: 3%; P < .001). Overall, male patients were more often free from AF-related symptoms and satisfied with the treatment.CONCLUSION: Catheter ablation of AF was associated with a distinct sex-related outcome and complication profile that requires consideration in clinical practice.",

keywords = "Atrial Fibrillation/surgery, Catheter Ablation/adverse effects, Female, Germany, Humans, Male, Middle Aged, Prognosis, Registries, Risk Assessment, Sex Factors",

author = "Zylla, {Maura M} and Johannes Brachmann and Thorsten Lewalter and Ellen Hoffmann and Karl-Heinz Kuck and Dietrich Andresen and Stephan Willems and Lars Eckardt and J{\"u}rgen Tebbenjohanns and Spitzer, {Stefan G} and Burghard Schumacher and Matthias Hochadel and Jochen Senges and Katus, {Hugo A} and Dierk Thomas",

year = "2016",

month = sep,

doi = "10.1016/j.hrthm.2016.06.005",

language = "English",

volume = "13",

pages = "1837--44",

journal = "HEART RHYTHM",

issn = "1547-5271",

publisher = "Elsevier",

number = "9",

}

RIS

TY - JOUR

T1 - Sex-related outcome of atrial fibrillation ablation: Insights from the German Ablation Registry

AU - Zylla, Maura M

AU - Brachmann, Johannes

AU - Lewalter, Thorsten

AU - Hoffmann, Ellen

AU - Kuck, Karl-Heinz

AU - Andresen, Dietrich

AU - Willems, Stephan

AU - Eckardt, Lars

AU - Tebbenjohanns, Jürgen

AU - Spitzer, Stefan G

AU - Schumacher, Burghard

AU - Hochadel, Matthias

AU - Senges, Jochen

AU - Katus, Hugo A

AU - Thomas, Dierk

PY - 2016/9

Y1 - 2016/9

N2 - BACKGROUND: Stratification of patients with atrial fibrillation (AF) according to mechanistic and prognostic criteria may optimize the effectiveness and safety of catheter ablation. In women, AF is associated with more severe symptoms and worse prognosis.OBJECTIVE: We sought to assess sex-related differences in catheter ablation procedures and outcome in a large cohort of patients with AF.METHODS: A total of 3652 patients (1198 women [33%]; 2454 men [67%]) included in the German Ablation Registry were analyzed. Periprocedural parameters and outcome at 12-month follow-up were compared between male and female patients.RESULTS: Women were older at the time of ablation (women: 63.6 years; men: 59.1 years; P < .0001) and exhibited a higher prevalence of paroxysmal AF (women: 72%; men: 61%; P < .0001). They were less often affected by cardiovascular disease and reduced left ventricular function. Energy application duration and overall procedure duration were shorter in women. Conversely, the rate of major inhospital complications was increased in female patients (1.9% vs 0.8%; P = .023) and mainly driven by major bleeding events. At follow-up, women experienced higher AF recurrence rates (women: 50%; men: 45%; P = .017) and more often received oral medication for rhythm and rate control. In addition, the rate of pacemaker implantation was higher in the female cohort. Women more frequently reported femoral access site complications (women: 6%; men: 3%; P < .001). Overall, male patients were more often free from AF-related symptoms and satisfied with the treatment.CONCLUSION: Catheter ablation of AF was associated with a distinct sex-related outcome and complication profile that requires consideration in clinical practice.

AB - BACKGROUND: Stratification of patients with atrial fibrillation (AF) according to mechanistic and prognostic criteria may optimize the effectiveness and safety of catheter ablation. In women, AF is associated with more severe symptoms and worse prognosis.OBJECTIVE: We sought to assess sex-related differences in catheter ablation procedures and outcome in a large cohort of patients with AF.METHODS: A total of 3652 patients (1198 women [33%]; 2454 men [67%]) included in the German Ablation Registry were analyzed. Periprocedural parameters and outcome at 12-month follow-up were compared between male and female patients.RESULTS: Women were older at the time of ablation (women: 63.6 years; men: 59.1 years; P < .0001) and exhibited a higher prevalence of paroxysmal AF (women: 72%; men: 61%; P < .0001). They were less often affected by cardiovascular disease and reduced left ventricular function. Energy application duration and overall procedure duration were shorter in women. Conversely, the rate of major inhospital complications was increased in female patients (1.9% vs 0.8%; P = .023) and mainly driven by major bleeding events. At follow-up, women experienced higher AF recurrence rates (women: 50%; men: 45%; P = .017) and more often received oral medication for rhythm and rate control. In addition, the rate of pacemaker implantation was higher in the female cohort. Women more frequently reported femoral access site complications (women: 6%; men: 3%; P < .001). Overall, male patients were more often free from AF-related symptoms and satisfied with the treatment.CONCLUSION: Catheter ablation of AF was associated with a distinct sex-related outcome and complication profile that requires consideration in clinical practice.

KW - Atrial Fibrillation/surgery

KW - Catheter Ablation/adverse effects

KW - Female

KW - Germany

KW - Humans

KW - Male

KW - Middle Aged

KW - Prognosis

KW - Registries

KW - Risk Assessment

KW - Sex Factors

U2 - 10.1016/j.hrthm.2016.06.005

DO - 10.1016/j.hrthm.2016.06.005

M3 - SCORING: Journal article

C2 - 27289011

VL - 13

SP - 1837

EP - 1844

JO - HEART RHYTHM

JF - HEART RHYTHM

SN - 1547-5271

IS - 9

ER -