Sex-related differences in patients presenting with heart failure-related cardiogenic shock
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Sex-related differences in patients presenting with heart failure-related cardiogenic shock. / Sundermeyer, Jonas; Kellner, Caroline; Beer, Benedikt N; Besch, Lisa; Dettling, Angela; Bertoldi, Letizia Fausta; Blankenberg, Stefan; Dauw, Jeroen; Dindane, Zouhir; Eckner, Dennis; Eitel, Ingo; Graf, Tobias; Horn, Patrick; Jozwiak-Nozdrzykowska, Joanna; Kirchhof, Paulus; Kluge, Stefan; Linke, Axel; Landmesser, Ulf; Luedike, Peter; Lüsebrink, Enzo; Majunke, Nicolas; Mangner, Norman; Maniuc, Octavian; Möbius-Winkler, Sven; Nordbeck, Peter; Orban, Martin; Pappalardo, Federico; Pauschinger, Matthias; Pazdernik, Michal; Proudfoot, Alastair; Kelham, Matthew; Rassaf, Tienush; Scherer, Clemens; Schulze, Paul Christian; Schwinger, Robert H G; Skurk, Carsten; Sramko, Marek; Tavazzi, Guido; Thiele, Holger; Villanova, Luca; Morici, Nuccia; Winzer, Ephraim B; Westermann, Dirk; Schrage, Benedikt.
In: CLIN RES CARDIOL, Vol. 113, No. 4, 04.2024, p. 612-625.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Sex-related differences in patients presenting with heart failure-related cardiogenic shock
AU - Sundermeyer, Jonas
AU - Kellner, Caroline
AU - Beer, Benedikt N
AU - Besch, Lisa
AU - Dettling, Angela
AU - Bertoldi, Letizia Fausta
AU - Blankenberg, Stefan
AU - Dauw, Jeroen
AU - Dindane, Zouhir
AU - Eckner, Dennis
AU - Eitel, Ingo
AU - Graf, Tobias
AU - Horn, Patrick
AU - Jozwiak-Nozdrzykowska, Joanna
AU - Kirchhof, Paulus
AU - Kluge, Stefan
AU - Linke, Axel
AU - Landmesser, Ulf
AU - Luedike, Peter
AU - Lüsebrink, Enzo
AU - Majunke, Nicolas
AU - Mangner, Norman
AU - Maniuc, Octavian
AU - Möbius-Winkler, Sven
AU - Nordbeck, Peter
AU - Orban, Martin
AU - Pappalardo, Federico
AU - Pauschinger, Matthias
AU - Pazdernik, Michal
AU - Proudfoot, Alastair
AU - Kelham, Matthew
AU - Rassaf, Tienush
AU - Scherer, Clemens
AU - Schulze, Paul Christian
AU - Schwinger, Robert H G
AU - Skurk, Carsten
AU - Sramko, Marek
AU - Tavazzi, Guido
AU - Thiele, Holger
AU - Villanova, Luca
AU - Morici, Nuccia
AU - Winzer, Ephraim B
AU - Westermann, Dirk
AU - Schrage, Benedikt
N1 - © 2024. The Author(s).
PY - 2024/4
Y1 - 2024/4
N2 - BACKGROUND: Heart failure-related cardiogenic shock (HF-CS) accounts for a significant proportion of all CS cases. Nevertheless, there is a lack of evidence on sex-related differences in HF-CS, especially regarding use of treatment and mortality risk in women vs. men. This study aimed to investigate potential differences in clinical presentation, use of treatments, and mortality between women and men with HF-CS.METHODS: In this international observational study, patients with HF-CS (without acute myocardial infarction) from 16 tertiary-care centers in five countries were enrolled between 2010 and 2021. Logistic and Cox regression models were used to assess differences in clinical presentation, use of treatments, and 30-day mortality in women vs. men with HF-CS.RESULTS: N = 1030 patients with HF-CS were analyzed, of whom 290 (28.2%) were women. Compared to men, women were more likely to be older, less likely to have a known history of heart failure or cardiovascular risk factors, and lower rates of highly depressed left ventricular ejection fraction and renal dysfunction. Nevertheless, CS severity as well as use of treatments were comparable, and female sex was not independently associated with 30-day mortality (53.0% vs. 50.8%; adjusted HR 0.94, 95% CI 0.75-1.19).CONCLUSIONS: In this large HF-CS registry, sex disparities in risk factors and clinical presentation were observed. Despite these differences, the use of treatments was comparable, and both sexes exhibited similarly high mortality rates. Further research is necessary to evaluate if sex-tailored treatment, accounting for the differences in cardiovascular risk factors and clinical presentation, might improve outcomes in HF-CS.
AB - BACKGROUND: Heart failure-related cardiogenic shock (HF-CS) accounts for a significant proportion of all CS cases. Nevertheless, there is a lack of evidence on sex-related differences in HF-CS, especially regarding use of treatment and mortality risk in women vs. men. This study aimed to investigate potential differences in clinical presentation, use of treatments, and mortality between women and men with HF-CS.METHODS: In this international observational study, patients with HF-CS (without acute myocardial infarction) from 16 tertiary-care centers in five countries were enrolled between 2010 and 2021. Logistic and Cox regression models were used to assess differences in clinical presentation, use of treatments, and 30-day mortality in women vs. men with HF-CS.RESULTS: N = 1030 patients with HF-CS were analyzed, of whom 290 (28.2%) were women. Compared to men, women were more likely to be older, less likely to have a known history of heart failure or cardiovascular risk factors, and lower rates of highly depressed left ventricular ejection fraction and renal dysfunction. Nevertheless, CS severity as well as use of treatments were comparable, and female sex was not independently associated with 30-day mortality (53.0% vs. 50.8%; adjusted HR 0.94, 95% CI 0.75-1.19).CONCLUSIONS: In this large HF-CS registry, sex disparities in risk factors and clinical presentation were observed. Despite these differences, the use of treatments was comparable, and both sexes exhibited similarly high mortality rates. Further research is necessary to evaluate if sex-tailored treatment, accounting for the differences in cardiovascular risk factors and clinical presentation, might improve outcomes in HF-CS.
U2 - 10.1007/s00392-024-02392-8
DO - 10.1007/s00392-024-02392-8
M3 - SCORING: Journal article
C2 - 38353681
VL - 113
SP - 612
EP - 625
JO - CLIN RES CARDIOL
JF - CLIN RES CARDIOL
SN - 1861-0684
IS - 4
ER -
