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Sex-related differences in non-urothelial variant histology, non-muscle invasive bladder cancer

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Sex-related differences in non-urothelial variant histology, non-muscle invasive bladder cancer. / Flammia, Rocco Simone; Chierigo, Francesco; Würnschimmel, Christoph; Wenzel, Mike; Horlemann, Benedikt; Tian, Zhen; Borghesi, Marco; Leonardo, Costantino; Tilki, Derya; Shariat, Shahrokh F; Anceschi, Umberto; Chun, Felix K H; Terrone, Carlo; Saad, Fred; Gallucci, Michele; Karakiewicz, Pierre I.

In: CENT EUR J UROL, Vol. 75, No. 3, 2022, p. 240-247.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Flammia, RS, Chierigo, F, Würnschimmel, C, Wenzel, M, Horlemann, B, Tian, Z, Borghesi, M, Leonardo, C, Tilki, D, Shariat, SF, Anceschi, U, Chun, FKH, Terrone, C, Saad, F, Gallucci, M & Karakiewicz, PI 2022, 'Sex-related differences in non-urothelial variant histology, non-muscle invasive bladder cancer', CENT EUR J UROL, vol. 75, no. 3, pp. 240-247. https://doi.org/10.5173/ceju.2022.0053

APA

Flammia, R. S., Chierigo, F., Würnschimmel, C., Wenzel, M., Horlemann, B., Tian, Z., Borghesi, M., Leonardo, C., Tilki, D., Shariat, S. F., Anceschi, U., Chun, F. K. H., Terrone, C., Saad, F., Gallucci, M., & Karakiewicz, P. I. (2022). Sex-related differences in non-urothelial variant histology, non-muscle invasive bladder cancer. CENT EUR J UROL, 75(3), 240-247. https://doi.org/10.5173/ceju.2022.0053

Vancouver

Flammia RS, Chierigo F, Würnschimmel C, Wenzel M, Horlemann B, Tian Z et al. Sex-related differences in non-urothelial variant histology, non-muscle invasive bladder cancer. CENT EUR J UROL. 2022;75(3):240-247. https://doi.org/10.5173/ceju.2022.0053

Bibtex

@article{3f3dd9b36fd54803a7448d99de77fc28,
title = "Sex-related differences in non-urothelial variant histology, non-muscle invasive bladder cancer",
abstract = "INTRODUCTION: Non-urothelial variant histology (VH), non-muscle invasive bladder cancer (NMIBC) has received little attention in contemporary urologic literature. Specifically, the effect of female sex on stage at presentation, as well as on cancer-specific mortality (CSM) have not been previously examined in VH NMIBC. Our aim was to test the effect of female sex on stage at presentation and CSM in VH NMIBC.MATERIAL AND METHODS: Within the Surveillance, Epidemiology, and End Results (SEER) database (2004-2016), we identified patients aged ≥18 years, with histologically confirmed VH NMIBC. Logistic regression models addressed T1 stage at diagnosis after multivariable adjustments for tumor grade, age and race/ethnicity. Before Kaplan-Meier plots and Cox regression analyses, propensity score matched adjusting for histological variants, T-stage, tumor grade, age and race/ethnicity was performed.RESULTS: Overall, 2,205 VH NMIBC patients were identified. Of those, 28% (n = 607) were female. Females were older (77 vs 74 years, p <0.001) and more frequently harbored T1 stage (55 vs 45%, p <0.001). Female sex independently predicted T1 stage (odds ratio [OR] = 1.66, 95% Confidence Interval [CI] = 1.35-2.03, p <0.001). Female sex also exhibited higher CSM, after matching for all assessable variables, including stage (hazard ratio [HR] = 1.91, 95% CI = 1.45-2.54, p <0.001).CONCLUSIONS: In VH NMIBC, female sex is an indicator of higher rate of T1 stage and, fully independently of stage, female sex also results in higher CSM.",
author = "Flammia, {Rocco Simone} and Francesco Chierigo and Christoph W{\"u}rnschimmel and Mike Wenzel and Benedikt Horlemann and Zhen Tian and Marco Borghesi and Costantino Leonardo and Derya Tilki and Shariat, {Shahrokh F} and Umberto Anceschi and Chun, {Felix K H} and Carlo Terrone and Fred Saad and Michele Gallucci and Karakiewicz, {Pierre I}",
note = "Copyright by Polish Urological Association.",
year = "2022",
doi = "10.5173/ceju.2022.0053",
language = "English",
volume = "75",
pages = "240--247",
journal = "CENT EUR J UROL",
issn = "2080-4806",
publisher = "Panstwowy Zaklad Wydawnictw Lekarskich",
number = "3",

}

RIS

TY - JOUR

T1 - Sex-related differences in non-urothelial variant histology, non-muscle invasive bladder cancer

AU - Flammia, Rocco Simone

AU - Chierigo, Francesco

AU - Würnschimmel, Christoph

AU - Wenzel, Mike

AU - Horlemann, Benedikt

AU - Tian, Zhen

AU - Borghesi, Marco

AU - Leonardo, Costantino

AU - Tilki, Derya

AU - Shariat, Shahrokh F

AU - Anceschi, Umberto

AU - Chun, Felix K H

AU - Terrone, Carlo

AU - Saad, Fred

AU - Gallucci, Michele

AU - Karakiewicz, Pierre I

N1 - Copyright by Polish Urological Association.

PY - 2022

Y1 - 2022

N2 - INTRODUCTION: Non-urothelial variant histology (VH), non-muscle invasive bladder cancer (NMIBC) has received little attention in contemporary urologic literature. Specifically, the effect of female sex on stage at presentation, as well as on cancer-specific mortality (CSM) have not been previously examined in VH NMIBC. Our aim was to test the effect of female sex on stage at presentation and CSM in VH NMIBC.MATERIAL AND METHODS: Within the Surveillance, Epidemiology, and End Results (SEER) database (2004-2016), we identified patients aged ≥18 years, with histologically confirmed VH NMIBC. Logistic regression models addressed T1 stage at diagnosis after multivariable adjustments for tumor grade, age and race/ethnicity. Before Kaplan-Meier plots and Cox regression analyses, propensity score matched adjusting for histological variants, T-stage, tumor grade, age and race/ethnicity was performed.RESULTS: Overall, 2,205 VH NMIBC patients were identified. Of those, 28% (n = 607) were female. Females were older (77 vs 74 years, p <0.001) and more frequently harbored T1 stage (55 vs 45%, p <0.001). Female sex independently predicted T1 stage (odds ratio [OR] = 1.66, 95% Confidence Interval [CI] = 1.35-2.03, p <0.001). Female sex also exhibited higher CSM, after matching for all assessable variables, including stage (hazard ratio [HR] = 1.91, 95% CI = 1.45-2.54, p <0.001).CONCLUSIONS: In VH NMIBC, female sex is an indicator of higher rate of T1 stage and, fully independently of stage, female sex also results in higher CSM.

AB - INTRODUCTION: Non-urothelial variant histology (VH), non-muscle invasive bladder cancer (NMIBC) has received little attention in contemporary urologic literature. Specifically, the effect of female sex on stage at presentation, as well as on cancer-specific mortality (CSM) have not been previously examined in VH NMIBC. Our aim was to test the effect of female sex on stage at presentation and CSM in VH NMIBC.MATERIAL AND METHODS: Within the Surveillance, Epidemiology, and End Results (SEER) database (2004-2016), we identified patients aged ≥18 years, with histologically confirmed VH NMIBC. Logistic regression models addressed T1 stage at diagnosis after multivariable adjustments for tumor grade, age and race/ethnicity. Before Kaplan-Meier plots and Cox regression analyses, propensity score matched adjusting for histological variants, T-stage, tumor grade, age and race/ethnicity was performed.RESULTS: Overall, 2,205 VH NMIBC patients were identified. Of those, 28% (n = 607) were female. Females were older (77 vs 74 years, p <0.001) and more frequently harbored T1 stage (55 vs 45%, p <0.001). Female sex independently predicted T1 stage (odds ratio [OR] = 1.66, 95% Confidence Interval [CI] = 1.35-2.03, p <0.001). Female sex also exhibited higher CSM, after matching for all assessable variables, including stage (hazard ratio [HR] = 1.91, 95% CI = 1.45-2.54, p <0.001).CONCLUSIONS: In VH NMIBC, female sex is an indicator of higher rate of T1 stage and, fully independently of stage, female sex also results in higher CSM.

U2 - 10.5173/ceju.2022.0053

DO - 10.5173/ceju.2022.0053

M3 - SCORING: Journal article

C2 - 36381153

VL - 75

SP - 240

EP - 247

JO - CENT EUR J UROL

JF - CENT EUR J UROL

SN - 2080-4806

IS - 3

ER -